Clopamide: Difference between revisions

Clopamide
Clinical data
ATC code	C03BA03 (WHO) ;
Identifiers
	IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-; benzamide;
CAS Number	636-54-4;
PubChem CID	2804;
ChemSpider	2702 ;
UNII	17S83WON0I;
KEGG	D02460 ;
CompTox Dashboard (EPA)	DTXSID1022847 ;
ECHA InfoCard	100.010.238
Chemical and physical data
Formula	C14H20ClN3O3S
Molar mass	345.846 g/mol g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N;
	InChI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N ;
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Revision as of 22:27, 9 August 2011

Clopamide is a piperidine diuretic.

Mechanism of Action of Clopamide: Clopamide is categorised as a thiazide like drug and works in similar way as the thiazide diuretics do. It acts at the Proximal Convoluted tubule site of the nephron where it inhibits the sodium-chloride cotransporter. Clopamide selectively binds at the chloride binding site of the sodium chloride cotransporter in the PCT cells on the luminal side and thus intereferes with the reabsorption of NaCl and thus causing an equiosmolar excretion of water along with NaCl.

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 | ATC_suffix = BA03
 | PubChem = 2804
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 | DrugBank =
 | KEGG_Ref = {{keggcite|correct|kegg}}