Eltoprazine: Difference between revisions
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'''Eltoprazine''' ('''DU- |
'''Eltoprazine''' ('''DU-28,853''') is a [[piperazine|phenylpiperazine]] and so-called serenic, or antiaggressive [[drug]], used as a research chemical in scientific studies.<ref name="pmid2091890">{{cite journal | author = Olivier B, Mos J, Rasmussen D. | title = Behavioural pharmacology of the serenic, eltoprazine | journal = Drug Metabol Drug Interact. | volume = 8 | issue = 1-2 | pages = 31-83 | year = 1990 | pmid = 2091890 }}</ref> It is closely related to several other piperazines, including [[fluprazine]], [[batoprazine]], [[DU 28412]], [[flesinoxan]], and [[TFMPP]], as well as more distantly to the [[azapirone]]s such as [[buspirone]]. Eltoprazine acts as an [[agonist]] at the [[5-HT1A|5-HT<sub>1A</sub>]] and [[5-HT1B|5-HT<sub>1B</sub>]] receptors, and as an [[antagonist]] at the [[5-HT2C|5-HT<sub>2C</sub>]] receptor.<ref name="pmid1982626">{{cite journal | author = Schipper J, Tulp MT, Sijbesma H. | title = Neurochemical profile of eltoprazine. | journal = Drug Metabol Drug Interact. | volume = 8 | issue = 1-2 | pages = 85-114 | year = 1990 | pmid = 1982626 }}</ref> Its serenic properties may actually be mediated by anxiogenesis.<ref name="pmid11224163">{{cite journal | author = Rodgers RJ, Cole JC, Cobain MR, Daly P, Doran PJ, Eells JR, Wallis P. | title = Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP. | journal = Behav Pharmacol. | volume = 3 | issue = 6 | pages = 621-634 | year = 1992 | pmid = 11224163 }}</ref> |
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Revision as of 03:30, 15 October 2009
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| Formula | C12H16N2O2 |
| Molar mass | 220.121 g/mol g·mol−1 |
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Eltoprazine (DU-28,853) is a phenylpiperazine and so-called serenic, or antiaggressive drug, used as a research chemical in scientific studies.[1] It is closely related to several other piperazines, including fluprazine, batoprazine, DU 28412, flesinoxan, and TFMPP, as well as more distantly to the azapirones such as buspirone. Eltoprazine acts as an agonist at the 5-HT1A and 5-HT1B receptors, and as an antagonist at the 5-HT2C receptor.[2] Its serenic properties may actually be mediated by anxiogenesis.[3]
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References
- ^ Olivier B, Mos J, Rasmussen D. (1990). "Behavioural pharmacology of the serenic, eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 31–83. PMID 2091890.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Schipper J, Tulp MT, Sijbesma H. (1990). "Neurochemical profile of eltoprazine". Drug Metabol Drug Interact. 8 (1–2): 85–114. PMID 1982626.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Rodgers RJ, Cole JC, Cobain MR, Daly P, Doran PJ, Eells JR, Wallis P. (1992). "Anxiogenic-like effects of fluprazine and eltoprazine in the mouse elevated plus-maze: profile comparisons with 8-OH-DPAT, CGS 12066B, TFMPP and mCPP". Behav Pharmacol. 3 (6): 621–634. PMID 11224163.
{{cite journal}}: CS1 maint: multiple names: authors list (link)