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'''S-15535''' is a [[piperazine]] [[drug]] and research chemical used in scientific studies. It is a potent and highly selective [[5-HT1A|5-HT<sub>1A</sub>]] [[receptor]] [[Ligand_(biochemistry)|ligand]] which acts as an [[agonist]] and [[Antagonist (pharmacology)|antagonist]] (weak partial agonist) at the presynaptic and postsynaptic 5-HT<sub>1A</sub> receptors, respectively.<ref name="pmid8381359">{{cite journal | author = Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL. | title = S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively. | journal = Eur J Pharmacol. | volume = 230 | issue = 1 | pages = 99-102 | year = 1993 | pmid = 8381359 }}</ref><ref name="pmid8301575">{{cite journal | author = Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, et al. | title = Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. | journal = J Pharmacol Exp Ther. | volume = 268 | issue = 1 | pages = 337-352 | year = 1994 | pmid = 8301575 }}</ref><ref name="pmid9223549">{{cite journal | author = Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A. | title = S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. | journal = J Pharmacol Exp Ther. | volume = 282 | issue = 1 | pages = 132-147 | year = 1997 | pmid = 9223549 }}</ref><ref name="pmid9723787">{{cite journal | author = Lejeune F, Millan MJ. | title = Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. | journal = Synapse. | volume = 30 | issue = 2 | pages = 172-180 | year = 1998 | pmid = 9723787 }}</ref> |
'''S-15535''' is a [[piperazine]] [[drug]] and research chemical used in scientific studies. It is a potent and highly selective [[5-HT1A|5-HT<sub>1A</sub>]] [[receptor]] [[Ligand_(biochemistry)|ligand]] which acts as an [[agonist]] and [[Antagonist (pharmacology)|antagonist]] (weak [[partial agonist]]) at the presynaptic and postsynaptic 5-HT<sub>1A</sub> receptors, respectively.<ref name="pmid8381359">{{cite journal | author = Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL. | title = S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively. | journal = Eur J Pharmacol. | volume = 230 | issue = 1 | pages = 99-102 | year = 1993 | pmid = 8381359 }}</ref><ref name="pmid8301575">{{cite journal | author = Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V, et al. | title = Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. | journal = J Pharmacol Exp Ther. | volume = 268 | issue = 1 | pages = 337-352 | year = 1994 | pmid = 8301575 }}</ref><ref name="pmid9223549">{{cite journal | author = Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A. | title = S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity. | journal = J Pharmacol Exp Ther. | volume = 282 | issue = 1 | pages = 132-147 | year = 1997 | pmid = 9223549 }}</ref><ref name="pmid9723787">{{cite journal | author = Lejeune F, Millan MJ. | title = Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535. | journal = Synapse. | volume = 30 | issue = 2 | pages = 172-180 | year = 1998 | pmid = 9723787 }}</ref> |
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Revision as of 11:56, 30 April 2009
S-15535 is a piperazine drug and research chemical used in scientific studies. It is a potent and highly selective 5-HT1A receptor ligand which acts as an agonist and antagonist (weak partial agonist) at the presynaptic and postsynaptic 5-HT1A receptors, respectively.[1][2][3][4]
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References
- ^ Millan MJ, Rivet JM, Canton H, Lejeune F, Gobert A, Widdowson P, Bervoets K, Brocco M, Peglion JL. (1993). "S 15535: a highly selective benzodioxopiperazine 5-HT1A receptor ligand which acts as an agonist and an antagonist (weak partial agonist) at presynaptic and postsynaptic sites respectively". Eur J Pharmacol. 230 (1): 99–102. PMID 8381359.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Millan MJ, Canton H, Gobert A, Lejeune F, Rivet JM, Bervoets K, Brocco M, Widdowson P, Mennini T, Audinot V; et al. (1994). "Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists". J Pharmacol Exp Ther. 268 (1): 337–352. PMID 8301575.
{{cite journal}}: Explicit use of et al. in:|author=(help)CS1 maint: multiple names: authors list (link) - ^ Millan MJ, Newman-Tancredi A, Rivet JM, Brocco M, Lacroix P, Audinot V, Cistarelli L, Gobert A. (1997). "S 15535, a novel benzodioxopiperazine ligand of serotonin (5-HT)1A receptors: I. Interaction with cloned human (h)5-HT1A, dopamine hD2/hD3 and h alpha2A-adrenergic receptors in relation to modulation of cortical monoamine release and activity in models of potential antidepressant activity". J Pharmacol Exp Ther. 282 (1): 132–147. PMID 9223549.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Lejeune F, Millan MJ. (1998). "Induction of burst firing in ventral tegmental area dopaminergic neurons by activation of serotonin (5-HT)1A receptors: WAY 100,635-reversible actions of the highly selective ligands, flesinoxan and S 15535". Synapse. 30 (2): 172–180. PMID 9723787.