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{{Short description|Pseudogene in the species Homo sapiens}}
{{Infobox_gene}}
{{Technical|date=November 2023}}{{Infobox_gene}}
'''Putative gonadotropin-releasing hormone II receptor''' is a [[protein]] that in humans is encoded by the ''GNRHR2'' [[gene]].<ref name="pmid11707068">{{cite journal |vauthors=Faurholm B, Millar RP, Katz AA | title = The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci | journal = Genomics | volume = 78 | issue = 1–2 | pages = 15–8 |date=Nov 2001 | pmid = 11707068 | pmc = | doi = 10.1006/geno.2001.6650 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814| accessdate = }}</ref>
'''Putative gonadotropin-releasing hormone II receptor''' is a [[protein]] that in humans is encoded by the ''GNRHR2'' [[gene]].<ref name="pmid11707068">{{cite journal |vauthors=Faurholm B, Millar RP, Katz AA | title = The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci | journal = Genomics | volume = 78 | issue = 1–2 | pages = 15–8 |date=Nov 2001 | pmid = 11707068 | doi = 10.1006/geno.2001.6650 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814}}</ref>


== Function ==
== Function ==


The receptor for gonadotropin releasing hormone 2 ([[GnRH2]]) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane [[G protein-coupled receptor]]. However, in human, the [[N-terminus]] of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional [[C-terminus|C-terminal]] multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed [[pseudogene]] of GnRHR2 is also on chromosome 14.<ref name="entrez"/>
The receptor for gonadotropin-releasing hormone 2 ([[GnRH2]]) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane [[G protein-coupled receptor]]. However, in humans, the [[N-terminus]] of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional [[C-terminus|C-terminal]] multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed [[pseudogene]] of GnRHR2 is also on chromosome 14.<ref name="entrez"/>


==See also==
==See also==
Line 14: Line 15:
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | author=Neill JD |title=GnRH and GnRH receptor genes in the human genome |journal=Endocrinology |volume=143 |issue= 3 |pages= 737–43 |year= 2002 |pmid= 11861490 |doi=10.1210/en.143.3.737 }}
*{{cite journal | author=Neill JD |title=GnRH and GnRH receptor genes in the human genome |journal=Endocrinology |volume=143 |issue= 3 |pages= 737–43 |year= 2002 |pmid= 11861490 |doi=10.1210/endo.143.3.8705 |doi-access=free }}
*{{cite journal |vauthors=Millar R, Conklin D, Lofton-Day C |title=A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript |journal=J. Endocrinol. |volume=162 |issue= 1 |pages= 117–26 |year= 1999 |pmid= 10396028 |doi=10.1677/joe.0.1620117 |display-authors=etal}}
*{{cite journal |vauthors=Millar R, Conklin D, Lofton-Day C |title=A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript |journal=J. Endocrinol. |volume=162 |issue= 1 |pages= 117–26 |year= 1999 |pmid= 10396028 |doi=10.1677/joe.0.1620117 |display-authors=etal|doi-access=free }}
*{{cite journal |vauthors=Neill JD, Duck LW, Sellers JC, Musgrove LC |title=A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 1012–8 |year= 2001 |pmid= 11352653 |doi= 10.1006/bbrc.2001.4678 }}
*{{cite journal |vauthors=Neill JD, Duck LW, Sellers JC, Musgrove LC |title=A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 1012–8 |year= 2001 |pmid= 11352653 |doi= 10.1006/bbrc.2001.4678 }}
*{{cite journal |vauthors=van Biljon W, Wykes S, Scherer S |title=Type II gonadotropin-releasing hormone receptor transcripts in human sperm |journal=Biol. Reprod. |volume=67 |issue= 6 |pages= 1741–9 |year= 2003 |pmid= 12444048 |doi=10.1095/biolreprod.101.002808 |display-authors=etal}}
*{{cite journal |vauthors=van Biljon W, Wykes S, Scherer S |title=Type II gonadotropin-releasing hormone receptor transcripts in human sperm |journal=Biol. Reprod. |volume=67 |issue= 6 |pages= 1741–9 |year= 2003 |pmid= 12444048 |doi=10.1095/biolreprod.101.002808 |display-authors=etal|doi-access=free }}
*{{cite journal |vauthors=Morgan K, Conklin D, Pawson AJ |title=A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12 |journal=Endocrinology |volume=144 |issue= 2 |pages= 423–36 |year= 2003 |pmid= 12538601 |doi=10.1210/en.2002-220622 |display-authors=etal}}
*{{cite journal |vauthors=Morgan K, Conklin D, Pawson AJ |title=A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12 |journal=Endocrinology |volume=144 |issue= 2 |pages= 423–36 |year= 2003 |pmid= 12538601 |doi=10.1210/en.2002-220622 |display-authors=etal|doi-access=free }}
*{{cite journal |vauthors=Pawson AJ, Maudsley S, Morgan K |title=Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment |journal=Endocrinology |volume=146 |issue= 6 |pages= 2639–49 |year= 2005 |pmid= 15761034 |doi= 10.1210/en.2005-0133 |display-authors=etal}}
*{{cite journal |vauthors=Pawson AJ, Maudsley S, Morgan K |title=Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment |journal=Endocrinology |volume=146 |issue= 6 |pages= 2639–49 |year= 2005 |pmid= 15761034 |doi= 10.1210/en.2005-0133 |display-authors=etal|doi-access=free }}
*{{cite journal |vauthors=Eicke N, Günthert AR, Viereck V |title=GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs |journal=Eur. J. Endocrinol. |volume=153 |issue= 4 |pages= 605–12 |year= 2005 |pmid= 16189182 |doi= 10.1530/eje.1.02005 |display-authors=etal}}
*{{cite journal |vauthors=Eicke N, Günthert AR, Viereck V |title=GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs |journal=Eur. J. Endocrinol. |volume=153 |issue= 4 |pages= 605–12 |year= 2005 |pmid= 16189182 |doi= 10.1530/eje.1.02005 |display-authors=etal|doi-access= }}
*{{cite journal |vauthors=Ikemoto T, Park MK |title=Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors |journal=Genomics |volume=87 |issue= 4 |pages= 459–62 |year= 2006 |pmid= 16406723 |doi= 10.1016/j.ygeno.2005.11.005 }}
*{{cite journal |vauthors=Ikemoto T, Park MK |title=Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors |journal=Genomics |volume=87 |issue= 4 |pages= 459–62 |year= 2006 |pmid= 16406723 |doi= 10.1016/j.ygeno.2005.11.005 |doi-access= free }}
*{{cite journal |vauthors=Parker JD, Malik M, Catherino WH |title=Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor |journal=Fertil. Steril. |volume=88 |issue= 1 |pages= 39–46 |year= 2007 |pmid= 17296196 |doi= 10.1016/j.fertnstert.2006.11.098 }}
*{{cite journal |vauthors=Parker JD, Malik M, Catherino WH |title=Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor |journal=Fertil. Steril. |volume=88 |issue= 1 |pages= 39–46 |year= 2007 |pmid= 17296196 |doi= 10.1016/j.fertnstert.2006.11.098 |s2cid=23070647 |url=https://zenodo.org/record/1258947 |doi-access=free }}
{{refend}}
{{refend}}


==External links==
==External links==
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3212 | title = Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
* {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3212 | title = Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology }}


{{NLM content}}
{{NLM content}}
{{G protein-coupled receptors}}
{{G protein-coupled receptors}}


[[Category:G protein coupled receptors]]
[[Category:G protein-coupled receptors]]


{{transmembranereceptor-stub}}
{{transmembranereceptor-stub}}

Latest revision as of 21:40, 3 April 2024

GNRHR2
Identifiers
AliasesGNRHR2, GnRH-II-R, gonadotropin releasing hormone receptor 2 (pseudogene)
External IDsGeneCards: GNRHR2; OMA:GNRHR2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

114814

n/a

Ensembl

ENSG00000211451

n/a

UniProt

n
a

n/a

RefSeq (mRNA)

NM_057163
NM_206994

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 1: 145.92 – 145.93 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[3][4]

Function

[edit]

The receptor for gonadotropin-releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in humans, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In humans, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[4]

See also

[edit]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000211451 – Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Faurholm B, Millar RP, Katz AA (Nov 2001). "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics. 78 (1–2): 15–8. doi:10.1006/geno.2001.6650. PMID 11707068.
  4. ^ a b "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2".

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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