Frizzled-7: Difference between revisions
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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
{{Infobox_gene}} |
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'''Frizzled-7''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164 | bibcode =1998PNAS...9510164T }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 |
'''Frizzled-7''' '''(Fd-7)''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164 | bibcode =1998PNAS...9510164T | doi-access = free }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324}}</ref> |
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Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez"/> |
Members of the '[[frizzled]]' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez"/> |
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==Interactions== |
==Interactions== |
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Fz-7 has been shown to [[Protein-protein interaction|interact]] with [[DLG4]].<ref name=pmid12067714>{{cite journal |last=Hering |first=Heike |author2=Sheng Morgan |date=June 2002|title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue=1–3 |pages=185–9 |location = Netherlands| issn = 0014-5793| pmid = 12067714 |doi=10.1016/S0014-5793(02)02831-4 |s2cid=39243103 |doi-access=free }}</ref> |
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==See also== |
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* [[Frizzled]] |
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==References== |
==References== |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770 | pmc=21233 |display-authors=etal|bibcode=1997PNAS...94.6770F}} |
*{{cite journal |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770 | pmc=21233 |display-authors=etal|bibcode=1997PNAS...94.6770F|doi-access=free }} |
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*{{cite journal |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 }} |
*{{cite journal |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4 |s2cid=39243103 |doi-access=free }} |
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*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }} |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 |doi-access= free }} |
*{{cite journal |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 |doi-access= free }} |
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*{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |display-authors=etal}} |
*{{cite journal |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |s2cid=32817238 |display-authors=etal}} |
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*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} |
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}} |
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*{{cite journal |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}} |
*{{cite journal |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}} |
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*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R }} |
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }} |
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*{{cite journal |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}} |
*{{cite journal |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }} |
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*{{cite journal |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal|doi-access=free }} |
*{{cite journal |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal|doi-access=free }} |
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*{{cite journal |vauthors=Struewing IT, Barnett CD, Zhang W |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 |display-authors=etal}} |
*{{cite journal |vauthors=Struewing IT, Barnett CD, Zhang W |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 |display-authors=etal}} |
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==External links== |
==External links== |
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*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | title = Frizzled Receptors: FZD<sub>7</sub> |
*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | title = Frizzled Receptors: FZD<sub>7</sub> | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303205141/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | url-status = dead }} |
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{{NLM content}} |
{{NLM content}} |
Latest revision as of 10:27, 10 March 2024
Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.[5][6][7]
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.[7]
Interactions
[edit]Fz-7 has been shown to interact with DLG4.[8]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000155760 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041075 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
- ^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
- ^ a b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
- ^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3). Netherlands: 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. S2CID 39243103.
Further reading
[edit]- Finch PW, He X, Kelley MJ, et al. (1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–5. Bibcode:1997PNAS...94.6770F. doi:10.1073/pnas.94.13.6770. PMC 21233. PMID 9192640.
- Hering H, Sheng M (2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3): 185–9. doi:10.1016/S0014-5793(02)02831-4. PMID 12067714. S2CID 39243103.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
- Omoto S, Hayashi T, Kitahara K, et al. (2004). "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. doi:10.1080/13816810490514270. PMID 15370539. S2CID 32817238.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Vincan E, Darcy PK, Smyth MJ, et al. (2005). "Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth". Differentiation. 73 (4): 142–53. doi:10.1111/j.1432-0436.2005.00015.x. PMID 15901282.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.
- Vincan E, Darcy PK, Farrelly CA, et al. (2007). "Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids". Oncogene. 26 (16): 2340–52. doi:10.1038/sj.onc.1210026. PMID 17016432.
- Struewing IT, Barnett CD, Zhang W, et al. (2007). "Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1". Exp. Cell Res. 313 (16): 3526–41. doi:10.1016/j.yexcr.2007.07.012. PMID 17716656.
External links
[edit]- "Frizzled Receptors: FZD7". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.