Frizzled-7: Difference between revisions

FZD7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4Z33
Identifiers
Aliases	FZD7, FzE3, frizzled class receptor 7
External IDs	OMIM: 603410; MGI: 108570; HomoloGene: 20751; GeneCards: FZD7; OMA:FZD7 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	202,038,441 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	59,526,114 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; germinal epithelium; ; urethra; ; lactiferous duct; ; tibia; ; parotid gland; ; cerebellar vermis; ; parietal pleura; ; cardiac muscle tissue of right atrium; ; seminal vesicula;
	Top expressed in
	vestibular membrane of cochlear duct; ; medullary collecting duct; ; renal corpuscle; ; ascending aorta; ; vestibular sensory epithelium; ; Epithelium of choroid plexus; ; aortic valve; ; saccule; ; triceps brachii muscle; ; masseter muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; frizzled binding; signal transducer activity; Wnt-protein binding; protein binding; transmembrane signaling receptor activity; phosphatidylinositol-4,5-bisphosphate binding; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; recycling endosome membrane; endosome; endosome membrane;
Biological process	negative regulation of cell-substrate adhesion; cellular response to retinoic acid; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; regulation of transcription, DNA-templated; positive regulation of epithelial cell proliferation involved in wound healing; T cell differentiation in thymus; non-canonical Wnt signaling pathway via JNK cascade; negative regulation of ectodermal cell fate specification; somatic stem cell division; positive regulation of JNK cascade; Wnt signaling pathway; stem cell population maintenance; positive regulation of transcription, DNA-templated; multicellular organism development; cell surface receptor signaling pathway; skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration; neuron differentiation; canonical Wnt signaling pathway; substrate adhesion-dependent cell spreading; positive regulation of phosphorylation; signal transduction; mesenchymal to epithelial transition; Wnt signaling pathway, planar cell polarity pathway; negative regulation of cardiac muscle cell differentiation; regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8324
	14369
	ENSG00000155760
	ENSMUSG00000041075
	O75084
	Q61090
	NM_003507
	NM_008057
	NP_003498
	NP_032083
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 10:27, 10 March 2024

Frizzled-7 (Fd-7) is a protein that in humans is encoded by the FZD7 gene.^[5]^[6]^[7]

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.^[7]

Interactions

Fz-7 has been shown to interact with DLG4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155760 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041075 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.
^ Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.
^ ^a ^b "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".
^ Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3). Netherlands: 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. S2CID 39243103.

External links

"Frizzled Receptors: FZD₇". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-04.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155760 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041075 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9707618-5] Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K (September 1998). "A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals". Proc Natl Acad Sci U S A. 95 (17): 10164–9. Bibcode:1998PNAS...9510164T. doi:10.1073/pnas.95.17.10164. PMC 21479. PMID 9707618.

[pmid9813155-6] Sagara N, Toda G, Hirai M, Terada M, Katoh M (December 1998). "Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7". Biochem Biophys Res Commun. 252 (1): 117–22. doi:10.1006/bbrc.1998.9607. PMID 9813155.

[entrez-7] "Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)".

[pmid12067714-8] Hering, Heike; Sheng Morgan (June 2002). "Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95". FEBS Lett. 521 (1–3). Netherlands: 185–9. doi:10.1016/S0014-5793(02)02831-4. ISSN 0014-5793. PMID 12067714. S2CID 39243103.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=8324}}
+{{Infobox_gene}}
-'''Frizzled-7''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal | author = Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164  }}</ref><ref name="pmid9813155">{{cite journal | author = Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | pmc =  | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324| accessdate = }}</ref>
+'''Frizzled-7''' '''(Fd-7)''' is a [[protein]] that in humans is encoded by the ''FZD7'' [[gene]].<ref name="pmid9707618">{{cite journal |vauthors=Tanaka S, Akiyoshi T, Mori M, Wands JR, Sugimachi K | title = A novel frizzled gene identified in human esophageal carcinoma mediates APC/beta-catenin signals | journal = Proc Natl Acad Sci U S A | volume = 95 | issue = 17 | pages = 10164–9 | date=September 1998| pmid = 9707618 | pmc = 21479 | doi =10.1073/pnas.95.17.10164  | bibcode =1998PNAS...9510164T | doi-access = free }}</ref><ref name="pmid9813155">{{cite journal |vauthors=Sagara N, Toda G, Hirai M, Terada M, Katoh M | title = Molecular cloning, differential expression, and chromosomal localization of human frizzled-1, frizzled-2, and frizzled-7 | journal = Biochem Biophys Res Commun | volume = 252 | issue = 1 | pages = 117–22 | date=December 1998| pmid = 9813155 | doi = 10.1006/bbrc.1998.9607 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: FZD7 frizzled homolog 7 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8324}}</ref>
+Members of the '[[frizzled]]' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.  FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez"/>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins.  The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif.  FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.<ref name="entrez"/>
-}}
 ==Interactions==
-FZD7 has been shown to [[Protein-protein interaction|interact]] with [[DLG4]].<ref name=pmid12067714>{{cite journal |last=Hering |first=Heike |authorlink= |author2=Sheng Morgan |date=June 2002|title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue=1–3 |pages=185–9 |publisher= |location = Netherlands| issn = 0014-5793| pmid = 12067714 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(02)02831-4 }}</ref>
+Fz-7 has been shown to [[Protein-protein interaction|interact]] with [[DLG4]].<ref name=pmid12067714>{{cite journal |last=Hering |first=Heike |author2=Sheng Morgan |date=June 2002|title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue=1–3 |pages=185–9 |location = Netherlands| issn = 0014-5793| pmid = 12067714 |doi=10.1016/S0014-5793(02)02831-4 |s2cid=39243103 |doi-access=free }}</ref>
-==See also==
-* [[Frizzled]]
 ==References==
 {{reflist}}
-==External links==
-*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | title = Frizzled Receptors: FZD<sub>7</sub> | accessdate = | author = | authorlink = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Finch PW, He X, Kelley MJ |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770  | pmc=21233  |display-authors=etal|bibcode=1997PNAS...94.6770F|doi-access=free }}
-{{PBB_Further_reading
+*{{cite journal  |vauthors=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4  |s2cid=39243103 |doi-access=free }}
-| citations =
-*{{cite journal  | author=Finch PW, He X, Kelley MJ, et al. |title=Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 13 |pages= 6770–5 |year= 1997 |pmid= 9192640 |doi=10.1073/pnas.94.13.6770  | pmc=21233  }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Hering H, Sheng M |title=Direct interaction of Frizzled-1, -2, -4, and -7 with PDZ domains of PSD-95 |journal=FEBS Lett. |volume=521 |issue= 1–3 |pages= 185–9 |year= 2002 |pmid= 12067714 |doi=10.1016/S0014-5793(02)02831-4  }}
+*{{cite journal  |vauthors=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, et al. |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal  |vauthors=Omoto S, Hayashi T, Kitahara K |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 |s2cid=32817238 |display-authors=etal}}
-*{{cite journal  | author=Yao R, Natsume Y, Noda T |title=MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap |journal=Oncogene |volume=23 |issue= 36 |pages= 6023–30 |year= 2005 |pmid= 15195140 |doi= 10.1038/sj.onc.1207817 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Omoto S, Hayashi T, Kitahara K, et al. |title=Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R) |journal=Ophthalmic Genet. |volume=25 |issue= 2 |pages= 81–90 |year= 2004 |pmid= 15370539 |doi= 10.1080/13816810490514270 }}
+*{{cite journal  |vauthors=Vincan E, Darcy PK, Smyth MJ |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x |display-authors=etal}}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, et al. |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal|bibcode=2005Natur.437.1173R |s2cid=4427026 }}
-*{{cite journal  | author=Vincan E, Darcy PK, Smyth MJ, et al. |title=Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth |journal=Differentiation |volume=73 |issue= 4 |pages= 142–53 |year= 2005 |pmid= 15901282 |doi= 10.1111/j.1432-0436.2005.00015.x }}
+*{{cite journal  |vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |s2cid=13709685 |display-authors=etal|doi-access=free }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, et al. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  |vauthors=Vincan E, Darcy PK, Farrelly CA |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 |display-authors=etal|doi-access=free }}
-*{{cite journal  | author=Lim J, Hao T, Shaw C, et al. |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
+*{{cite journal  |vauthors=Struewing IT, Barnett CD, Zhang W |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 |display-authors=etal}}
-*{{cite journal  | author=Vincan E, Darcy PK, Farrelly CA, et al. |title=Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids |journal=Oncogene |volume=26 |issue= 16 |pages= 2340–52 |year= 2007 |pmid= 17016432 |doi= 10.1038/sj.onc.1210026 }}
-*{{cite journal  | author=Struewing IT, Barnett CD, Zhang W, et al. |title=Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1 |journal=Exp. Cell Res. |volume=313 |issue= 16 |pages= 3526–41 |year= 2007 |pmid= 17716656 |doi= 10.1016/j.yexcr.2007.07.012 }}
-}}
 {{refend}}
+==External links==
+*{{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | title = Frizzled Receptors: FZD<sub>7</sub> | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | access-date = 2008-12-04 | archive-date = 2016-03-03 | archive-url = https://web.archive.org/web/20160303205141/http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3065 | url-status = dead }}
 {{NLM content}}
 {{G protein-coupled receptors|g4}}
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 {{DEFAULTSORT:Fzd7}}
-[[Category:G protein coupled receptors]]
+[[Category:G protein-coupled receptors]]
 {{transmembranereceptor-stub}}