Clopamide: Difference between revisions
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{{Short description|Chemical compound}} |
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{{Drugbox |
{{Drugbox |
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<!--Clinical data--> |
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| tradename = |
| tradename = Brinaldix |
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| Drugs.com = {{drugs.com|international|clopamide}} |
| Drugs.com = {{drugs.com|international|clopamide}} |
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| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> |
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<!--Chemical data--> |
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| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1 |
| C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1 |
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| molecular_weight = 345.846 g/mol |
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| smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N |
| smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N |
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| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
| StdInChI_Ref = {{stdinchicite|correct|chemspider}} |
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'''Clopamide''' (trade name Brinaldix) is a [[piperidine]] [[diuretic]].<ref>{{cite journal | vauthors = McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ | title = Clopamide: plasma concentrations and diuretic effect in humans | journal = Clinical Pharmacology and Therapeutics | volume = 42 | issue = 3 | pages = 299–304 | date = September 1987 | pmid = 3621784 | doi = 10.1038/clpt.1987.151 | s2cid = 20000178 }}</ref> |
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'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{Cite journal |
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| last1 = McNeil | first1 = J. J. |
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| last2 = Conway | first2 = E. L. |
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| last3 = Drummer | first3 = O. H. |
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| last4 = Howes | first4 = L. G. |
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| last5 = Christophidis | first5 = N. |
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| last6 = Louis | first6 = W. J. |
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| title = Clopamide: Plasma concentrations and diuretic effect in humans |
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| journal = Clinical Pharmacology and Therapeutics |
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| volume = 42 |
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| issue = 3 |
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| pages = 299–304 |
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| year = 1987 |
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| pmid = 3621784 | doi=10.1038/clpt.1987.151 |
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}}</ref> |
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==Mechanism of action== |
==Mechanism of action== |
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Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[distal convoluted tubule]] ( |
Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[distal convoluted tubule]] (DCT) of the [[nephron]] where it inhibits the [[sodium-chloride symporter]]. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of [[sodium chloride]], causing an equi[[osmolar]] excretion of water along with sodium chloride. |
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== References == |
== References == |
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<references /> |
<references /> |
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{{Diuretics}} |
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[[Category:Piperidines]] |
[[Category:Piperidines]] |
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[[Category:Sulfonamides]] |
[[Category:Sulfonamides]] |
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[[Category:Hydrazides]] |
[[Category:Hydrazides]] |
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[[Category:Drugs developed by Novartis]] |
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[[Category:Diuretics]] |
[[Category:Diuretics]] |
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[[Category:Carbonic anhydrase inhibitors]] |
[[Category:Carbonic anhydrase inhibitors]] |
Latest revision as of 20:04, 20 December 2023
Clinical data | |
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Trade names | Brinaldix |
AHFS/Drugs.com | International Drug Names |
ATC code | |
Identifiers | |
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CAS Number | |
PubChem CID | |
ChemSpider | |
UNII | |
KEGG | |
ChEMBL | |
CompTox Dashboard (EPA) | |
ECHA InfoCard | 100.010.238 |
Chemical and physical data | |
Formula | C14H20ClN3O3S |
Molar mass | 345.84 g·mol−1 |
3D model (JSmol) | |
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(what is this?) (verify) |
Clopamide (trade name Brinaldix) is a piperidine diuretic.[1]
Mechanism of action
[edit]Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.