Clopamide: Difference between revisions

Clopamide
Clinical data
Trade names	Brinaldix
AHFS/Drugs.com	International Drug Names
ATC code	C03BA03 (WHO) ;
Identifiers
	IUPAC name 4-chloro-N-(2,6-dimethyl-1-piperidyl)-3-sulfamoyl-; benzamide;
CAS Number	636-54-4 ;
PubChem CID	2804;
ChemSpider	2702 ;
UNII	17S83WON0I;
KEGG	D02460 ;
ChEMBL	ChEMBL1361347 ;
CompTox Dashboard (EPA)	DTXSID1022847 ;
ECHA InfoCard	100.010.238
Chemical and physical data
Formula	C14H20ClN3O3S
Molar mass	345.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N;
	InChI InChI=1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21) ; Key:LBXHRAWDUMTPSE-UHFFFAOYSA-N ;
	(what is this?) (verify)

Browse history interactively

← Previous edit

Content deleted Content added

VisualWikitext

Inline

Latest revision as of 20:04, 20 December 2023

Clopamide (trade name Brinaldix) is a piperidine diuretic.^[1]

Mechanism of action

Clopamide is categorised as a thiazide-like diuretic and works in similar way as the thiazide diuretics do. It acts in the kidneys, at the distal convoluted tubule (DCT) of the nephron where it inhibits the sodium-chloride symporter. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of sodium chloride, causing an equiosmolar excretion of water along with sodium chloride.

References

^ McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784. S2CID 20000178.

[1] McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ (September 1987). "Clopamide: plasma concentrations and diuretic effect in humans". Clinical Pharmacology and Therapeutics. 42 (3): 299–304. doi:10.1038/clpt.1987.151. PMID 3621784. S2CID 20000178.

[1]

@@ Line 1: / Line 1: @@
+{{Short description|Chemical compound}}
 {{Drugbox
 | Verifiedfields = changed
@@ Line 7: / Line 8: @@
 <!--Clinical data-->
-| tradename =
+| tradename =  Brinaldix
 | Drugs.com = {{drugs.com|international|clopamide}}
 | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
@@ Line 44: / Line 45: @@
 <!--Chemical data-->
 | C=14 | H=20 | Cl=1 | N=3 | O=3 | S=1
-| molecular_weight = 345.846 g/mol
 | smiles = O=C(NN1C(CCCC1C)C)c2ccc(Cl)c(c2)S(=O)(=O)N
 | StdInChI_Ref = {{stdinchicite|correct|chemspider}}
@@ Line 52: / Line 52: @@
 }}
+'''Clopamide''' (trade name Brinaldix) is a [[piperidine]] [[diuretic]].<ref>{{cite journal | vauthors = McNeil JJ, Conway EL, Drummer OH, Howes LG, Christophidis N, Louis WJ | title = Clopamide: plasma concentrations and diuretic effect in humans | journal = Clinical Pharmacology and Therapeutics | volume = 42 | issue = 3 | pages = 299–304 | date = September 1987 | pmid = 3621784 | doi = 10.1038/clpt.1987.151 | s2cid = 20000178 }}</ref>
-'''Clopamide''' (trade name '''Brinaldix''') is a [[piperidine]] [[diuretic]].<ref>{{Cite journal
-| last1 = McNeil | first1 = J. J.
-| last2 = Conway | first2 = E. L.
-| last3 = Drummer | first3 = O. H.
-| last4 = Howes | first4 = L. G.
-| last5 = Christophidis | first5 = N.
-| last6 = Louis | first6 = W. J.
-| title = Clopamide: Plasma concentrations and diuretic effect in humans
-| journal = Clinical Pharmacology and Therapeutics
-| volume = 42
-| issue = 3
-| pages = 299–304
-| year = 1987
-| pmid = 3621784 | doi=10.1038/clpt.1987.151
-}}</ref>
 ==Mechanism of action==
-Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[distal convoluted tubule]] (PCT) of the [[nephron]] where it inhibits the [[sodium-chloride symporter]]. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of [[sodium chloride]], causing an equi[[osmolar]] excretion of water along with sodium chloride.
+Clopamide is categorised as a [[thiazide-like diuretic]] and works in similar way as the [[thiazide]] diuretics do. It acts in the kidneys, at the [[distal convoluted tubule]] (DCT) of the [[nephron]] where it inhibits the [[sodium-chloride symporter]]. Clopamide selectively binds at the chloride binding site of the sodium-chloride symporter in the PCT cells on the luminal (interior) side and thus interferes with the reabsorption of [[sodium chloride]], causing an equi[[osmolar]] excretion of water along with sodium chloride.
 == References ==
 <references />
+{{Diuretics}}
 [[Category:Piperidines]]
 [[Category:Sulfonamides]]
 [[Category:Hydrazides]]
+[[Category:Drugs developed by Novartis]]
 [[Category:Diuretics]]
 [[Category:Carbonic anhydrase inhibitors]]