GPR116: Difference between revisions

ADGRF5
Identifiers
Aliases	ADGRF5, KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI: 2182928; HomoloGene: 9065; GeneCards: ADGRF5; OMA:ADGRF5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,954,943 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,770,448 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; renal medulla; ; right ventricle; ; metanephric glomerulus; ; vena cava; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; interventricular septum; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; soleus muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
NP_001074647; NP_001344261; NP_001391458; NP_001391459; NP_001391465;
	NP_001391470; NP_001391475; NP_001391477
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:39, 19 June 2022

Probable G-protein coupled receptor 116 is a protein that in humans is encoded by the GPR116 gene.^[5]^[6]^[7] GPR116 has now been shown to play an essential role in the regulation of lung surfactant homeostasis.^[8]^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)
^ Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.
^ "Entrez Gene: GPR116 G protein-coupled receptor 116".
^ Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.
^ Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003). "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America. 100 (8): 4903–8. Bibcode:2003PNAS..100.4903V. doi:10.1073/pnas.0230374100. PMC 153653. PMID 12679517.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069122 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056492 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Stacey, edited by S Yona, M Stacey (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 978-1-4419-7912-4. {{cite book}}: |first= has generic name (help)CS1 maint: multiple names: authors list (link)

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002). "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters. 531 (3): 407–14. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. S2CID 7449692.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013). "Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116". Cell Reports. 3 (5): 1457–64. doi:10.1016/j.celrep.2013.04.019. PMC 3695742. PMID 23684610.

[9] Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013). "Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D". PLOS ONE. 8 (7): e69451. Bibcode:2013PLoSO...869451F. doi:10.1371/journal.pone.0069451. PMC 3726689. PMID 23922714.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=221395}}
+{{Infobox gene}}
-'''Probable G-protein coupled receptor 116''' is a [[protein]] that in humans is encoded by the ''GPR116'' [[gene]].<ref>{{cite book|last=Stacey|first=edited by S Yona, M Stacey|title=Adhesion-GPCRs : structure to function|year=2010|publisher=Springer Science+Business Media|location=New York|isbn=978-1-4419-7912-4}}</ref> <ref name="pmid12435584">{{cite journal | author = Fredriksson R, Lagerstrom MC, Hoglund PJ, Schioth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Lett | volume = 531 | issue = 3 | pages = 407–14 | year = 2002 | month = Nov | pmid = 12435584 | pmc =  | doi =10.1016/S0014-5793(02)03574-3  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR116 G protein-coupled receptor 116| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221395| accessdate = }}</ref>
+'''Probable G-protein coupled receptor 116''' is a [[protein]] that in humans is encoded by the ''GPR116'' [[gene]].<ref>{{cite book|last=Stacey|first=edited by S Yona, M Stacey|title=Adhesion-GPCRs : structure to function|year=2010|publisher=Springer Science+Business Media|location=New York|isbn=978-1-4419-7912-4}}</ref><ref name="pmid12435584">{{cite journal | vauthors = Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB | title = Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions | journal = FEBS Letters | volume = 531 | issue = 3 | pages = 407–14 | date = Nov 2002 | pmid = 12435584 | doi = 10.1016/S0014-5793(02)03574-3 | s2cid = 7449692 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPR116 G protein-coupled receptor 116| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=221395}}</ref>  GPR116 has now been shown to play an essential role in the regulation of [[lung surfactant]] homeostasis.<ref>{{cite journal | vauthors = Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B | title = Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116 | journal = Cell Reports | volume = 3 | issue = 5 | pages = 1457–64 | date = May 2013 | pmid = 23684610 | doi = 10.1016/j.celrep.2013.04.019 | pmc=3695742}}</ref><ref>{{cite journal | vauthors = Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S | title = Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D | journal = PLOS ONE | volume = 8 | issue = 7 | pages = e69451 | year = 2013 | pmid = 23922714 | doi = 10.1371/journal.pone.0069451 | pmc=3726689| bibcode = 2013PLoSO...869451F | doi-access = free }}</ref>
+== References ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA | title = The G protein-coupled receptor repertoires of human and mouse | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 8 | pages = 4903–8 | date = Apr 2003 | pmid = 12679517 | pmc = 153653 | doi = 10.1073/pnas.0230374100 | bibcode = 2003PNAS..100.4903V | doi-access = free }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB | title = The human and mouse repertoire of the adhesion family of G-protein-coupled receptors | journal = Genomics | volume = 84 | issue = 1 | pages = 23–33 | date = Jul 2004 | pmid = 15203201 | doi = 10.1016/j.ygeno.2003.12.004 }}
-| citations =
-*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 5 |pages= 277–86 |year= 1999 |pmid= 9872452 |doi=10.1093/dnares/5.5.277  }}
+* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
-*{{cite journal  | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=10.1093/dnares/5.6.355  }}
-*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948  }}
-*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Vassilatis DK, Hohmann JG, Zeng H, ''et al.'' |title=The G protein-coupled receptor repertoires of human and mouse. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4903–8 |year= 2003 |pmid= 12679517 |doi= 10.1073/pnas.0230374100  | pmc=153653 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, ''et al.'' |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-*{{cite journal  | author=Liu T, Qian WJ, Gritsenko MA, ''et al.'' |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065  | pmc=1850943 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139  | pmc=1347501 }}
-}}
 {{refend}}
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 {{G protein-coupled receptors}}
-[[Category:G protein coupled receptors]]
+[[Category:G protein-coupled receptors]]
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