Talk:Phosphorylation

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This article is or was the subject of a Wiki Education Foundation-supported course assignment. Further details are available on the course page. Student editor(s): Fahad93khan, Mahmoud824, Ikhan94, Amassaly, Umarfar1993, Lpatin11235, Lintuohou, ImperfectBalance.

Above undated message substituted from Template:Dashboard.wikiedu.org assignment by PrimeBOT (talk) 06:35, 17 January 2022 (UTC) ==Phosphorylation within the Myocardium may represent a Force closely associated with Systole of the Heart. Dephosphorylation represents the opposed Force of Diastole.

Add reaction

A reaction diagram showing the biological phosphorylation reaction of commonly phosphorylated amino acids (i.e. tyrosine, serine, threonine) would be lovely. Neuroschizl (talk) 18:53, 6 December 2013 (UTC)

Untitled

How I can dephophorylate my protein sample? Please help (use alkaline Phosphatase or under strong alkaline conditions (beta elemination)...it really depends what you want to dephosphorylate (serine/threonine or tyrosine

My very personal point of view to this article: This article has the wrong contents. The definition in the first line is really really wrong. Phosph in terms of oxidative ~, photo ~, or substrate level ~ has the saem importance as protein phosphorylation. If you read the literature of 1950-1990, phosphorylation had no relevance to proteins. There so many more things than just fancy cancer research protein phosphorylation, Phosphoproteomics and Phosphorylomics! Cheers a Omics scientist

Does the phospphorylation sites have to reside in the cytosolic portion of the membrane proteins? Does secreted protein every get phosphorylated? I guess my question is: Are there kinases and phosphatases in the extracellular space? If someone can answer this question, could you please add it to the text. Thanks.

Merger proposal

The following discussion is closed. Please do not modify it. Subsequent comments should be made in a new section. A summary of the conclusions reached follows.

The result of this discussion was no consensus, not merged. D O N D E groovily Talk to me 05:12, 26 February 2012 (UTC)

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This page is more exhaustive than Protein phosphorylation and the information there should be incorporated here.--hroest 00:14, 11 January 2009 (UTC)

Protein Phoshorylation is a rather big subset of the general term and much of the research that has been done with regards to phoshorylation has been connected with proteins.Hence the two topics should be merged together as there is not much to phosphorylation other than protein phosphorylation.

• This should be a disambiguation page with links to
  • Protein phosphorylation
  • Substrate level phosphorylation
  • Oxidative phosphorylation
  • Photophosphorylation
  • Synthesis of organophosphates

--İnfoCan (talk) 16:39, 19 March 2009 (UTC)

Disagree with the merger proposal. Phosphorylation is not exclusive to proteins. Some of the material should be moved from phosphorylation to protein phosphorylation, but no merger. --Chibibrain (talk) 21:01, 26 November 2009 (UTC)

Agree Agree Agree —Preceding unsigned comment added by 68.110.81.118 (talk) 20:32, 12 June 2010 (UTC)

probably suggested by a biochemist. don't merge. —Preceding unsigned comment added by 76.230.238.93 (talk) 07:06, 22 February 2011 (UTC)

Agree: puts everything in one place — Preceding unsigned comment added by 74.89.70.58 (talk • contribs) 01:37, 10 November 2011 (UTC)

• Support merging Protein phosphorylation into Phosphorylation until such time as a split would be reasonable. Of course not all phosphorylation is protein phosphorylation, but the two topics overlap so much that a merge is reasonable at this time. Quasihuman | Talk 12:31, 12 February 2012 (UTC)

The discussion above is closed. Please do not modify it. Subsequent comments should be made on the appropriate discussion page. No further edits should be made to this discussion.

Pathway Additions?

I can't help but think this Wikipedia page could really be expanded upon with the addition of several figures detailing some example pathways and mechanisms in which phosphorylation works. The section on "function" is pretty detailed, but the inclusion of pictures could really add to the material and help to clarify any issues that people may have. Would it be a good idea to add some basic pathways that phosphorylation occurs in? Maybe create a "general" template with simple names such as "ligands," "receptors," "proteins," and "phosphorylates"? Just a little advice that I think could make this page even better! MChapman5 (talk) 00:19, 4 February 2013 (UTC)

Cotranslational phosphorylation?

The article says that "Protein phosphorylation is one type of post-translational modification" which is not technically correct. See this for reference http://www.ncbi.nlm.nih.gov/pubmed/21868676 I have reproduced these results myself - cotranslational phosphorylation is real! The truth is out there! — Preceding unsigned comment added by 2001:4CA0:200:3:200:5EFE:8D54:4514 (talk) 21:05, 27 February 2013 (UTC)

Merge Function section with corresponding section on Protein Phosphorylation page

The Function section on this page is largely overlapping with the same section on the Protein phosphorylation page. I suggest to merge the section from this page into the latter. The section here should be shortened significantly.

I have moved several sections already over to Protein phosphorylation but have to take a break now. I suggest to retain this page as a general overview of phosphorylation and focus on proteins in the Protein phosphorylation page. Peteruetz (talk) 17:47, 4 November 2016 (UTC)

Odd English?

Somebody has written the inscrutable: "The liver’s crucial role in controlling blood sugar concentrations by breaking down glucose into carbon dioxide and glycogen is characterized by the negative delta G value, which indicates that this is a point of regulation with." With what? This is a vague, clumsy, confusing expression. Can someone competent please amend? Thanks. Trevor H. (UK) 17:00, 23 August 2018 (UTC) — Preceding unsigned comment added by Trevor H. (talk • contribs)

Chem Rev

Maybe some of the older lit could be replaced by the updated info from a thematic issue of Chemical Reviews.

1. Ahn, N., Introduction:  Protein Phosphorylation and Signaling. Chemical Reviews 2001, 101, 2207-2208.
2. Newton, A. C., Protein Kinase C:  Structural and Spatial Regulation by Phosphorylation, Cofactors, and Macromolecular Interactions. Chemical Reviews 2001, 101, 2353-2364.
3. Haskell, M. D.; Slack, J. K.; Parsons, J. T.; Parsons, S. J., c-Src Tyrosine Phosphorylation of Epidermal Growth Factor Receptor, P190 RhoGAP, and Focal Adhesion Kinase Regulates Diverse Cellular Processes. Chemical Reviews 2001, 101, 2425-2440.
4. Saito, H., Histidine Phosphorylation and Two-Component Signaling in Eukaryotic Cells. Chemical Reviews 2001, 101, 2497-2510.

--Smokefoot (talk) 13:40, 18 February 2019 (UTC)

Addition of phosphate or phosphoryl?

This first sentence currently reads as so:

"In chemistry, phosphorylation (a phosphate group is added to a molecule) of a molecule is the attachment of a phosphoryl group. "

The parenthesised part is obviously meant to be a breakdown of the word but there is no need as 1. the article already starts with a definition of the word anyway and 2. phosphate and phosphoryl, as far as I can tell, are not the same thing. So which is it? Is phosphorylation the addition of a phosphoryl group or a phosphate group? As a layperson I could see it as either, as the only chemical structure of a phosphorylated protein I have seen had a phosphate group, but if the connecting oxygen atom was already part of a hydroxyl group, for example, then maybe it's still just the addition of a phosphoryl group.

Anditres (talk) 03:41, 15 December 2020 (UTC)