Talk:Ketorolac

Comment

ketorolac reacts with sodium azide in presence of sulphuric acid and sodiumhydroxide , what is the formation of the product?

US specific information

Actually, "Dosage, availability and price" part is valid for US only, and US is not a typical example when we are talking about drugs. In Russia, for example, price is about 10 times less, and I think it's available over-the-counter in most of the world.

Good point, but it's still a good entry otherwise. I just got an injection of Toradol and wondered what it was. It answered all my questions. Eperotao 14:59, 13 July 2007 (UTC)

Proposal to merge Acular into Ketorolac

I'm interested: what are the reasons in favour of a merger? User:Jeff Dahl, it looks like you are proposing this. Could you tell us why it's a good idea? Personally, I don't feel strongly either way. However, I do note that the Ketorolac article now specifically excludes ophthalmic solutions of ketorolac, and that would have to change. --Jdlh | Talk 07:16, 4 September 2007 (UTC)

My reasoning on the proposed merger, besides the obvious point that it is the same active drug, is that the acular article doesn't really add much information except manufacturers and citations. The sources listed, links etc. are great, but the body of the article is little more than a few sentences that could be better integrated into the ketorolac article. Even if the acular article were expanded by putting in the drug information, it would be just a duplication of the ketorolac article. By merging, we can make the coverage of the ketorolac article more thorough. I am eager to hear what everyone thinks about it. Jeff Dahl 15:41, 4 September 2007 (UTC)

I have no objection to a merger, though don't feel strongly in favour either. The Wikipedia:Be bold principle gives you license to go ahead if no objection appears. If you want more input than this trickle, you could ask Wikipedia:WikiProject Pharmacology, or look at how other editors have handled this same topic for other cases. --Jdlh | Talk 18:58, 5 September 2007 (UTC)

It has now been a few days, no objections to merger, so I have performed it.Jeff Dahl 21:16, 11 September 2007 (UTC)

Thank you for being bold. --Jdlh | Talk 17:17, 13 September 2007 (UTC)

IUPAC Name

Perhaps something like this

There are two IUPAC names given in the article:

1. (±)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid (C₁₅H₁₃NO₃)
2. 2-amino-2-(hydroxymethyl)-1,3-propanediol (C₄H₁₁NO₃)

The pictured compound is the first of those two. The drug is named "ketorolac tromethamine" and is actually a salt in 1:1 ratio of the two components. I think should supply a picture containing both structures. ralmin 00:41, 16 October 2007 (UTC)

Ketarolaco page

Can we have a forwarding page from ketorolaco into this one? I'm not sure how to do that, but it's important since in Latin America this is how it's known (as it states correctly in the article) but could not be found in a wikipedia search (or google for that matter).Cpt ricard (talk) 07:13, 28 September 2008 (UTC)

Short-term is important

I need to reinsert 'short-term' because this 'unique' characteristic is important.

Best Regards,

Barbara (WVS) ✐ ✉ 21:16, 30 March 2017 (UTC)

ok 12.244.210.174 (talk) 21:54, 7 November 2023 (UTC)

Instructions for clinician monitoring

In my view this is right on the edge of, and probably into, WP:NOTHOWTO. Added here and here and here

Clinicians monitor the effects of ketorolac during treatment to identify complications that may arise. This is an ongoing assessment that typically includes obtaining the medical history, identifying concurrent prescription medications, herbal supplements, over-the-counter medications and the presence of renal impairment, asthma, rhinitis, hepatic impairment and lab values. Pertinent lab tests include liver function tests, bleeding time, BUN, serum creatinine and and electrolyte levels.

References

Pinging WT:MED Jytdog (talk) 16:03, 31 March 2017 (UTC)

Isn't this one of the most dangerous NSAIDs? Monitoring wouldn't surprise me in that case. (But if it's never taken for more than five days, then when does the monitoring happen?) WhatamIdoing (talk) 16:16, 31 March 2017 (UTC)

probably WP:NOTHOWTO...IMO--Ozzie10aaaa (talk) 21:42, 31 March 2017 (UTC)

yep. similar content had been added here to another drug article. There is a line between "how it is used" and "how to use it" and we try to keep on the "how it is used" side of that. yes for stuff with a narrow therapeutic window and chronic use like coumadin we talk about monitoring - part of how it is used there for sure. Jytdog (talk) 16:25, 31 March 2017 (UTC)

It is notable because it only can be taken for a limited time and has none of the effects of opioids. The monitoring occurs during the short length of the administration (as referenced) because most of the time a person is hospitalized when they take it. Ongoing assessment occurs constantly in a NICU simply because the person is hooked up to so many machines. The presentation of adverse effects are monitored because they are so serious. The concurrent use of acetaminophen is synergistic and improves pain control. Thanks for the input.

Best Regards,

Barbara (WVS) ✐ ✉ 16:29, 31 March 2017 (UTC)

Nobody is saying that ketorolac is not notable. we don't include routine monitoring, generally. Jytdog (talk) 16:34, 31 March 2017 (UTC)

Is NICU use common? I'd have guessed kidney stones or ovarian torsion or something in that range – but not newborns, at any rate. (Of course, I don't know much about what gets used in newborns, so maybe my guess is wrong.) WhatamIdoing (talk) 20:28, 31 March 2017 (UTC)

One of the review articles describes studies regarding the use of this med. It appears to be quite successful in controlling pain while at the same time avoiding the CNS respiratory depression that comes with other analgesics. So I guess its use in the NICU is often enough to warrant a review article.

Barbara (WVS) ✐ ✉ 12:36, 1 April 2017 (UTC)

On the original question, I'm not really feeling like this is HOWTO territory. On the question of whether it belongs in the article, I'd kind of like to know how often these tests usually get run. I took a quick look, and it appears that there are several different uses, including ocular administration, and the 'rules' might be different for different uses. Perhaps these tests only apply to long-term use? (Also, it's a little weird to present obtaining a medical history as part of monitoring; surely that ought to be part of the deciding-whether-to-prescribe-this step instead of an after-you're-already-taking-it step.) WhatamIdoing (talk) 01:32, 2 April 2017 (UTC)

WID, I took out the medical history mention. In my nursing courses we are taught, and our textbooks emphasize the observation of clients who begin a new medication and the monitoring that is performed. The references support this content, also. As a potential patient, I personally would like to know how someone would identify an emergent problem if it appears. Readers may find the monitoring during treatment section encyclopedic and keep it mind when they are receiving the med. In my experience, these tests are run every day. Even without this particular medication, the effects of other meds and treatments can seriously effect the liver, kidneys, immune system and lots of other things. I am probably guessing that projmed has been physician-centric for so long that the 'follow-up' care provided by other health personnel is sometimes de-emphasized. Your comments are appreciated and helpful.

Best Regards,

Barbara (WVS) ✐ ✉ 19:58, 3 April 2017 (UTC)

what you wrote there about your nursing training falls right into WP:NOTTEXTBOOK and WP:NOTHOWTO. Jytdog (talk) 22:56, 3 April 2017 (UTC)

Agree this bit "Clinicians monitor the effects of ketorolac during treatment to identify complications that may arise." is not appropriate." This is not clinical monitoring "This is an ongoing assessment that typically includes obtaining the medical history, identifying concurrent prescription medications, herbal supplements, over-the-counter medications and the presence of renal impairment, asthma, rhinitis, hepatic impairment and lab values." But is simple things one should think about before prescribing the stuff. Doc James (talk · contribs · email) 03:15, 10 April 2017 (UTC)

Could mention use for migraine

eg a 2013 review : Ketorolac in the treatment of acute migraine: a systematic review., and Gilmore, B; Michael, M (2011-02-01). "Treatment of acute migraine headache". American family physician. 83 (3): 271–80. PMID 21302868. - Could mention/describe use for migraine (which does mention K) ? - Rod57 (talk) 19:27, 21 November 2017 (UTC)

Preclinical research as preoperative alternative to chemotherapy for cancer

Anti-inflammation approach shows promise for preventing cancer metastasis - may be worth mentioning, now or soon. - Rod57 (talk) 09:16, 20 June 2019 (UTC)

Mention its use in Knives Out?

The drug is a significant part of the plot in Knives Out, mention here?Naraht (talk) 13:11, 21 December 2019 (UTC)

Unappropriate mention of paracetamol?

The first paragraph of the 'History' section currently contains the sentence "An IV form of paracetamol, which is not an NSAID, became available in Europe in 2009 and then in the US." This doesn't seem pertinent to an article about Ketorolac. 74.58.147.69 (talk) 14:30, 12 January 2021 (UTC)

The entire "History" section needs to be rewritten; it's not the history of the drug at all. --jpgordon^{𝄢𝄆 𝄐𝄇} 16:07, 12 January 2021 (UTC)

Ketorolac

Krtorolac 84.47.208.26 (talk) 13:56, 21 October 2022 (UTC)