The protein encoded by this gene is closely related to STAM, an adaptor protein involved in the downstream signaling of cytokine receptors, both of which contain a SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). Similar to STAM, this protein acts downstream of JAK kinases, and is phosphorylated in response to cytokine stimulation. This protein and STAM thus are thought to exhibit compensatory effects on the signaling pathway downstream of JAK kinases upon cytokine stimulation.[7]
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Mizuno E, Kawahata K, Okamoto A, Kitamura N, Komada M (Mar 2004). "Association with Hrs is required for the early endosomal localization, stability, and function of STAM". Journal of Biochemistry. 135 (3): 385–96. doi:10.1093/jb/mvh046. PMID15113837.
Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Analytical Chemistry. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID15144186.
Lechner MS, Schultz DC, Negorev D, Maul GG, Rauscher FJ (Jun 2005). "The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain". Biochemical and Biophysical Research Communications. 331 (4): 929–37. doi:10.1016/j.bbrc.2005.04.016. PMID15882967.
