PARP3

Poly [ADP-ribose] polymerase 3 is an enzyme that in humans is encoded by the PARP3 gene.

PARP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EOC, 3C49, 3C4H, 3CE0, 3FHB, 4GV0, 4GV2, 4GV4, 4L6Z, 4L70, 4L7L, 4L7N, 4L7O, 4L7P, 4L7R, 4L7U
Identifiers
Aliases	PARP3, ADPRT3, ADPRTL2, ADPRTL3, ARTD3, IRT1, PADPRT-3, poly(ADP-ribose) polymerase family member 3
External IDs	OMIM: 607726; MGI: 1891258; HomoloGene: 4005; GeneCards: PARP3; OMA:PARP3 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.2 Start 51,942,345 bp End 51,948,867 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 106,347,521 bp End 106,354,148 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal cortex left adrenal gland left adrenal cortex right lobe of liver apex of heart right lobe of thyroid gland left lobe of thyroid gland muscle layer of sigmoid colon transverse colon stromal cell of endometrium Top expressed in extraocular muscle ankle temporal muscle triceps brachii muscle digastric muscle sternocleidomastoid muscle vastus lateralis muscle gastrocnemius muscle mesenteric lymph nodes medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity glycosyltransferase activity catalytic activity NAD+ ADP-ribosyltransferase activity DNA ligase (ATP) activity protein ADP-ribosylase activity protein binding NAD DNA ADP-ribosyltransferase activity Cellular component cytoplasm site of double-strand break centriole cytoskeleton nucleus microtubule organizing center nucleolus chromosome Biological process protein localization to site of double-strand break DNA ligation involved in DNA repair lagging strand elongation regulation of mitotic spindle organization positive regulation of DNA ligation telomere maintenance double-strand break repair protein ADP-ribosylation DNA repair negative regulation of telomerase RNA reverse transcriptase activity protein poly-ADP-ribosylation DNA ADP-ribosylation negative regulation of isotype switching protein auto-ADP-ribosylation protein mono-ADP-ribosylation positive regulation of double-strand break repair via nonhomologous end joining cellular response to DNA damage stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10039 235587 Ensembl ENSG00000041880 ENSMUSG00000023249 UniProt Q9Y6F1 Q3ULW8 RefSeq (mRNA) NM_001003931 NM_001003935 NM_005485 NM_001370239 NM_001370240 NM_145619 NM_001311150 RefSeq (protein) NP_001003931 NP_005476 NP_001357168 NP_001357169 NP_001298079 NP_663594 Location (UCSC) Chr 3: 51.94 – 51.95 Mb Chr 9: 106.35 – 106.35 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene belongs to the PARP family. These enzymes modify nuclear proteins by poly-ADP-ribosylation, which is required for DNA repair, regulation of apoptosis, and maintenance of genomic stability. This gene encodes the poly(ADP-ribosyl)transferase 3, which is preferentially localized to the daughter centriole throughout the cell cycle. Alternatively spliced transcript variants encoding different isoforms have been identified.

Further reading

• Bashford CL, Chance B, Lloyd D, Poole RK (1981). "Oscillations of redox states in synchronously dividing cultures of Acanthamoeba castellanii and Schizosaccharomyces pombe". Biophys. J. 29 (1): 1–11. Bibcode:1980BpJ....29....1B. doi:10.1016/S0006-3495(80)85114-9. PMC 1328658. PMID 7260241.
• Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
• Berghammer H, Ebner M, Marksteiner R, Auer B (1999). "pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans". FEBS Lett. 449 (2–3): 259–63. doi:10.1016/S0014-5793(99)00448-2. PMID 10338144. S2CID 3251763.
• Still IH, Vince P, Cowell JK (2000). "Identification of a novel gene (ADPRTL1) encoding a potential Poly(ADP-ribosyl)transferase protein". Genomics. 62 (3): 533–6. doi:10.1006/geno.1999.6024. PMID 10644454.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Glowacki G, Braren R, Cetkovic-Cvrlje M, et al. (2001). "Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5". Gene. 275 (2): 267–77. doi:10.1016/S0378-1119(01)00608-4. PMID 11587854.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Augustin A, Spenlehauer C, Dumond H, et al. (2004). "PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression". J. Cell Sci. 116 (Pt 8): 1551–62. doi:10.1242/jcs.00341. PMID 12640039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Rouleau M, McDonald D, Gagné P, et al. (2007). "PARP-3 associates with polycomb group bodies and with components of the DNA damage repair machinery". J. Cell. Biochem. 100 (2): 385–401. doi:10.1002/jcb.21051. PMID 16924674. S2CID 25618577.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Lehtiö L, Jemth AS, Collins R, et al. (2009). "Structural basis for inhibitor specificity in human poly(ADP-ribose) polymerase-3". J. Med. Chem. 52 (9): 3108–3111. doi:10.1021/jm900052j. PMID 19354255.

External links

• PARP3 human gene location in the UCSC Genome Browser.
• PARP3 human gene details in the UCSC Genome Browser.