The Moco RNA motif is a conserved RNA structure [1] that is presumed to be a riboswitch that binds molybdenum cofactor or the related tungsten cofactor. Genetic experiments support the hypothesis that the Moco RNA motif corresponds to a genetic control element that responds to changing concentrations of molybdenum or tungsten cofactor.[2] As these cofactors are not available in purified form, in vitro binding assays cannot be performed. However, the genetic data, complex structure of the RNA and the failure to detect a protein involved in the regulation suggest that the Moco RNA motif corresponds to a class of riboswitches.
| Moco (molybdenum cofactor) riboswitch | |
|---|---|
 Predicted secondary structure and sequence conservation of MOCO_RNA_motif | |
| Identifiers | |
| Symbol | MOCO_RNA_motif |
| Rfam | RF01055 |
| Other data | |
| RNA type | Cis-reg; riboswitch |
| Domain(s) | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
References
edit- ^ Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
- ^ a b Regulski EE, Moy RH, Weinberg Z, et al. (2008). "A widespread riboswitch candidate that controls bacterial genes involved in molybdenum cofactor and tungsten cofactor metabolism". Mol. Microbiol. 68 (4): 918–932. doi:10.1111/j.1365-2958.2008.06208.x. PMC 2408646. PMID 18363797.
External links
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