M101 or M-101 most often refers to:
- Messier 101, or the Pinwheel Galaxy, a spiral galaxy
- M101 howitzer, a 105 mm light howitzer
M101 or M-101 may also refer to:
- Myasishchev M-101T Gzhel, an aircraft produced in Russia
- Line M101 (Beijing Subway), a metro line under construction in Beijing, scheduled to open in 2027
- M101 (New York City bus), a bus route in Manhattan
- Hammond Organ, a Hammond Spinet Organ
- M-101 (Michigan highway), a state highway in Michigan
- HMS Sandown (M101), British naval ship commissioned in 1989, decommissioned in 2005.
- M-101 German Kriegsmarine minesweeper
- M101 'CROWS', USA Common Remotely Operated Weapon Station
This disambiguation page lists articles associated with the same title formed as a letter–number combination.
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