DLEU2

Deleted in lymphocytic leukemia 2 (non-protein coding) is a long non-coding RNA that in humans is encoded by the DLEU2 gene. In humans it is located on chromosome 13q14. The DLEU2 gene was originally identified as a potential tumour suppressor gene and is often deleted in patients with B-cell chronic lymphocytic leukemia.

DLEU2
Identifiers
Aliases	DLEU2, 1B4, BCMSUN, DLB2, LEU2, LINC00022, MIR15AHG, NCRNA00022, RFP2OS, TRIM13OS, deleted in lymphocytic leukemia 2 (non-protein coding)
External IDs	OMIM: 605766; GeneCards: DLEU2; OMA:DLEU2 - orthologs
Orthologs Species Human Mouse Entrez 8847 n/a Ensembl ENSG00000231607 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) n/a n/a PubMed search n/a
Wikidata
View/Edit Human

See also

• Long non-coding RNA

Further reading

• Kapanadze B, Makeeva N, Corcoran M, Jareborg N, Hammarsund M, Baranova A, Zabarovsky E, Vorontsova O, Merup M, Gahrton G, Jansson M, Yankovsky N, Einhorn S, Oscier D, Grandér D, Sangfelt O (Dec 2000). "Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in B-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14". Genomics. 70 (3): 327–334. doi:10.1006/geno.2000.6386. PMID 11161783.
• Migliazza A, Bosch F, Komatsu H, Cayanis E, Martinotti S, Toniato E, Guccione E, Qu X, Chien M, Murty VV, Gaidano G, Inghirami G, Zhang P, Fischer S, Kalachikov SM, Russo J, Edelman I, Efstratiadis A, Dalla-Favera R (Apr 2001). "Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia". Blood. 97 (7): 2098–2104. doi:10.1182/blood.V97.7.2098. PMID 11264177.
• Bullrich F, Fujii H, Calin G, Mabuchi H, Negrini M, Pekarsky Y, Rassenti L, Alder H, Reed JC, Keating MJ, Kipps TJ, Croce CM (Sep 2001). "Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene". Cancer Research. 61 (18): 6640–6648. PMID 11559527.
• Baranova A, Hammarsund M, Ivanov D, Skoblov M, Sangfelt O, Corcoran M, Borodina T, Makeeva N, Pestova A, Tyazhelova T, Nazarenko S, Gorreta F, Alsheddi T, Schlauch K, Nikitin E, Kapanadze B, Shagin D, Poltaraus A, Ivanovich Vorobiev A, Zabarovsky E, Lukianov S, Chandhoke V, Ibbotson R, Oscier D, Einhorn S, Grander D, Yankovsky N (Dec 2003). "Distinct organization of the candidate tumor suppressor gene RFP2 in human and mouse: multiple mRNA isoforms in both species- and human-specific antisense transcript RFP2OS". Gene. 321: 103–112. doi:10.1016/j.gene.2003.08.007. PMID 14636997.
• Corcoran MM, Hammarsund M, Zhu C, Lerner M, Kapanadze B, Wilson B, Larsson C, Forsberg L, Ibbotson RE, Einhorn S, Oscier DG, Grandér D, Sangfelt O (Aug 2004). "DLEU2 encodes an antisense RNA for the putative bicistronic RFP2/LEU5 gene in humans and mouse". Genes, Chromosomes & Cancer. 40 (4): 285–297. doi:10.1002/gcc.20046. PMID 15188451. S2CID 35917986.
• Skoblov M, Shakhbazov K, Oshchepkov D, Ivanov D, Guskova A, Ivanov D, Rubtsov P, Prasolov V, Yankovsky N, Baranova A (Apr 2006). "Human RFP2 gene promoter: unique structure and unusual strength". Biochemical and Biophysical Research Communications. 342 (3): 859–866. doi:10.1016/j.bbrc.2006.01.187. PMC 1994241. PMID 16499869.