Brevican

BCAN
Identifiers
Aliases	BCAN, BEHAB, CSPG7, Brevican
External IDs	OMIM: 600347; MGI: 1096385; HomoloGene: 7244; GeneCards: BCAN; OMA:BCAN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,659,532 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	88,000,230 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; Amygdala; ; anterior cingulate cortex; ; right frontal lobe; ; nucleus accumbens; ; caudate nucleus; ; putamen; ; ganglionic eminence; ; prefrontal cortex; ; Brodmann area 9;
	Top expressed in
	superior frontal gyrus; ; entorhinal cortex; ; primary visual cortex; ; perirhinal cortex; ; CA3 field; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; central gray substance of midbrain; ; nucleus of stria terminalis; ; superior colliculus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	hyaluronic acid binding; carbohydrate binding; extracellular matrix structural constituent;
Cellular component	membrane; extracellular region; lysosomal lumen; Golgi lumen; anchored component of membrane; extracellular matrix; glutamatergic synapse;
Biological process	skeletal system development; chondroitin sulfate biosynthetic process; extracellular matrix organization; central nervous system development; chondroitin sulfate catabolic process; dermatan sulfate biosynthetic process; hippocampus development; cell adhesion; synapse maturation;
	Sources:Amigo / QuickGO
Orthologs
	63827
	12032
	ENSG00000132692
	ENSMUSG00000004892
	Q96GW7
	Q61361
	NM_021948; NM_198427
	NM_001109758; NM_007529
	NP_068767; NP_940819
	NP_001103228; NP_031555
	Wikidata
View/Edit Human	View/Edit Mouse

Brevican core protein is a protein that in humans is encoded by the BCAN gene.^[5]^[6]^[7] Brevican is a member of the lectican protein family.

Brevican is localised to the surface of neurons in the brain.^[8] In melanocytic cells, BCAN gene expression may be regulated by MITF.^[9]

Brevican is involved in maintaining molecule networks around nuerones and may possibly be associated with slower brain ageing and Alzheimer's prevention.^[10]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132692 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000004892 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.
^ Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.
^ "Entrez Gene: BCAN brevican".
^ Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ Naddaf, Miryam (2024-12-09). "How fast is your brain ageing? Proteins in blood offer clues". Nature. doi:10.1038/d41586-024-04055-0. ISSN 1476-4687.

Hu B, Kong LL, Matthews RT, Viapiano MS (Sep 2008). "The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility". The Journal of Biological Chemistry. 283 (36): 24848–59. doi:10.1074/jbc.M801433200. PMC 3259830. PMID 18611854.
Seidenbecher CI, Richter K, Rauch U, Fässler R, Garner CC, Gundelfinger ED (Nov 1995). "Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms". The Journal of Biological Chemistry. 270 (45): 27206–12. doi:10.1074/jbc.270.45.27206. PMID 7592978.
Aspberg A, Miura R, Bourdoulous S, Shimonaka M, Heinegârd D, Schachner M, Ruoslahti E, Yamaguchi Y (Sep 1997). "The C-type lectin domains of lecticans, a family of aggregating chondroitin sulfate proteoglycans, bind tenascin-R by protein-protein interactions independent of carbohydrate moiety". Proceedings of the National Academy of Sciences of the United States of America. 94 (19): 10116–21. Bibcode:1997PNAS...9410116A. doi:10.1073/pnas.94.19.10116. PMC 23322. PMID 9294172.
Nakamura H, Fujii Y, Inoki I, Sugimoto K, Tanzawa K, Matsuki H, Miura R, Yamaguchi Y, Okada Y (Dec 2000). "Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90. doi:10.1074/jbc.M003875200. PMID 10986281.
Olin AI, Mörgelin M, Sasaki T, Timpl R, Heinegård D, Aspberg A (Jan 2001). "The proteoglycans aggrecan and Versican form networks with fibulin-2 through their lectin domain binding". The Journal of Biological Chemistry. 276 (2): 1253–61. doi:10.1074/jbc.M006783200. PMID 11038354.
Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A (Oct 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Xu XM, Chen Y, Chen J, Yang S, Gao F, Underhill CB, Creswell K, Zhang L (Sep 2003). "A peptide with three hyaluronan binding motifs inhibits tumor growth and induces apoptosis". Cancer Research. 63 (18): 5685–90. PMID 14522884.
Bekku Y, Su WD, Hirakawa S, Fässler R, Ohtsuka A, Kang JS, Sanders J, Murakami T, Ninomiya Y, Oohashi T (Sep 2003). "Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets". Molecular and Cellular Neurosciences. 24 (1): 148–59. doi:10.1016/S1044-7431(03)00133-7. PMID 14550776. S2CID 25762224.
Dong Y, Han X, Xue Y, Dong B, Guo X, Hu G, Zhu C, Lu Y (Feb 2004). "Secreted brevican mRNA is expressed in the adult rat pituitary". Biochemical and Biophysical Research Communications. 314 (3): 745–8. doi:10.1016/j.bbrc.2003.12.151. PMID 14741698.
Viapiano MS, Bi WL, Piepmeier J, Hockfield S, Matthews RT (Aug 2005). "Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas". Cancer Research. 65 (15): 6726–33. doi:10.1158/0008-5472.CAN-05-0585. PMID 16061654.
Nakada M, Miyamori H, Kita D, Takahashi T, Yamashita J, Sato H, Miura R, Yamaguchi Y, Okada Y (Sep 2005). "Human glioblastomas overexpress ADAMTS-5 that degrades brevican". Acta Neuropathologica. 110 (3): 239–46. doi:10.1007/s00401-005-1032-6. PMID 16133547. S2CID 25744956.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

External links

Human BCAN genome location and BCAN gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132692 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000004892 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11054543-5] Gary SC, Zerillo CA, Chiang VL, Gaw JU, Gray G, Hockfield S (Oct 2000). "cDNA cloning, chromosomal localization, and expression analysis of human BEHAB/brevican, a brain specific proteoglycan regulated during cortical development and in glioma". Gene. 256 (1–2): 139–47. doi:10.1016/S0378-1119(00)00362-0. PMID 11054543.

[pmid11873941-6] Nomoto H, Oohashi T, Hirakawa S, Ueki Y, Ohtsuki H, Ninomiya Y (Feb 2002). "Human BRAL1 and BCAN genes that belong to the link-module superfamily are tandemly arranged on chromosome 1q21-23". Acta Medica Okayama. 56 (1): 25–9. PMID 11873941.

[entrez-7] "Entrez Gene: BCAN brevican".

[pmid22537913-8] Frischknecht R, Seidenbecher CI (Jul 2012). "Brevican: a key proteoglycan in the perisynaptic extracellular matrix of the brain". The International Journal of Biochemistry & Cell Biology. 44 (7): 1051–4. doi:10.1016/j.biocel.2012.03.022. PMID 22537913.

[pmid19067971-9] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (Dec 2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell & Melanoma Research. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[10] Naddaf, Miryam (2024-12-09). "How fast is your brain ageing? Proteins in blood offer clues". Nature. doi:10.1038/d41586-024-04055-0. ISSN 1476-4687.

[5]

[6]

[7]

[1]

[2]

[3]

[4]

[8]

[9]

[10]

Brevican

References

Further reading

External links