BCL9L

B-cell CLL/lymphoma 9 like is a protein that in humans is encoded by the BCL9L gene.

BCL9L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XB1, 4UP0, 4UP5
Identifiers
Aliases	BCL9L, BCL9-2, DLNB11, B-cell CLL/lymphoma 9-like, B-cell CLL/lymphoma 9 like, B cell CLL/lymphoma 9 like, B9L, BCL9 like
External IDs	OMIM: 609004; MGI: 1933114; HomoloGene: 65615; GeneCards: BCL9L; OMA:BCL9L - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,893,875 bp End 118,925,926 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,394,122 bp End 44,423,193 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte right coronary artery stromal cell of endometrium right uterine tube gastric mucosa popliteal artery tibial arteries mucosa of ileum right ovary nipple Top expressed in basilar part of occipital bone splanchnocranium sphenoid bone thyroid cartilage basisphenoid Meckel's cartilage rib lip hyoid bone Rostral migratory stream More reference expression data BioGPS n/a
Gene ontology Molecular function transcription coactivator activity beta-catenin binding Cellular component nucleolus nucleus nucleoplasm beta-catenin-TCF complex Biological process regulation of cell morphogenesis regulation of transcription, DNA-templated negative regulation of transforming growth factor beta receptor signaling pathway positive regulation of epithelial to mesenchymal transition transcription, DNA-templated beta-catenin-TCF complex assembly canonical Wnt signaling pathway somatic stem cell population maintenance skeletal muscle cell differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283149 80288 Ensembl ENSG00000186174 ENSMUSG00000063382 UniProt Q86UU0 Q67FY2 RefSeq (mRNA) NM_182557 NM_001378213 NM_001378214 NM_030256 NM_001357490 RefSeq (protein) NP_872363 NP_001365142 NP_001365143 NP_084532 NP_001344419 Location (UCSC) Chr 11: 118.89 – 118.93 Mb Chr 9: 44.39 – 44.42 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Sampietro J, Dahlberg CL, Cho US, Hinds TR, Kimelman D, Xu W (2006). "Crystal structure of a beta-catenin/BCL9/Tcf4 complex". Mol. Cell. 24 (2): 293–300. doi:10.1016/j.molcel.2006.09.001. PMID 17052462.
• Miller TC, Rutherford TJ, Johnson CM, Fiedler M, Bienz M (2010). "Allosteric remodelling of the histone H3 binding pocket in the Pygo2 PHD finger triggered by its binding to the B9L/BCL9 co-factor". J. Mol. Biol. 401 (5): 969–84. doi:10.1016/j.jmb.2010.07.007. PMC 2927781. PMID 20637214.
• Brembeck FH, Wiese M, Zatula N, Grigoryan T, Dai Y, Fritzmann J, Birchmeier W (2011). "BCL9-2 promotes early stages of intestinal tumor progression". Gastroenterology. 141 (4): 1359–70, 1370.e1–3. doi:10.1053/j.gastro.2011.06.039. PMID 21703997.
• Matsuura K, Jigami T, Taniue K, Morishita Y, Adachi S, Senda T, Nonaka A, Aburatani H, Nakamura T, Akiyama T (2011). "Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway". Nat Commun. 2: 548. Bibcode:2011NatCo...2..548M. doi:10.1038/ncomms1551. PMID 22109522.
• Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH (2014). "The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis". Oncotarget. 5 (16): 6770–87. doi:10.18632/oncotarget.2252. PMC 4196162. PMID 25149534.
• El-Hage P, Petitalot A, Monsoro-Burq AH, Maczkowiak F, Driouch K, Formstecher E, Camonis J, Sabbah M, Bièche I, Lidereau R, Lallemand F (2015). "The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells". Mol. Cancer Res. 13 (5): 902–12. doi:10.1158/1541-7786.MCR-14-0180. PMID 25678599.