380 may refer to:
- 380 (number), the natural number and/or integer
- Western-calendar years:
- Products:
- Airbus A380, double-deck, four-engined airliner
- 380 bulb, 12V dual-brightness (21W/5W, typically automotive) light bulb
- .380 ACP, a rimless, straight-walled pistol cartridge
- Hung Shui Kiu stop, Hong Kong; station code
- ".380" (Daredevil)