research-article

How do amino acid mismatches affect the outcome of hematopoietic cell transplants?: a structural perspective

Authors:

Effie W. Petersdorf,

Philip BradleyAuthors Info & Claims

BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology

Pages 627 - 633

https://doi.org/10.1145/1854776.1854893

Published: 02 August 2010 Publication History

Abstract

The success of hematopoietic cell transplantation from an unrelated donor depends in part on the degree of Human Histocompatibility Leukocyte Antigen (HLA) matching between donor and patient. We present a structure-based analysis of HLA mismatching, focusing on individual amino acid mismatches and their effect on peptide binding specificity. Using molecular modeling simulations of HLA-peptide interactions, we find evidence that amino acid mismatches predicted to perturb peptide binding specificity are associated with higher risk of mortality in a large and diverse dataset of patient-donor pairs assembled by the International Histocompatibility Working Group in Hematopoietic Cell Transplantation consortium. Although preliminary, this analysis may represent a first step toward sequence-based prediction of relative risk for HLA allele mismatches.

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Cited By

Yanover CBradley P(2011)Large-scale characterization of peptide-MHC binding landscapes with structural simulationsProceedings of the National Academy of Sciences10.1073/pnas.1018165108108:17(6981-6986)Online publication date: 8-Apr-2011
https://doi.org/10.1073/pnas.1018165108

How do amino acid mismatches affect the outcome of hematopoietic cell transplants?: a structural perspective
1. Applied computing
  1. Life and medical sciences

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cover image ACM Conferences

BCB '10: Proceedings of the First ACM International Conference on Bioinformatics and Computational Biology

August 2010

705 pages

ISBN:9781450304382

DOI:10.1145/1854776

General Chairs:
Aidong Zhang
SUNY at Buffalo
,
Mark Borodovsky
Georgia Tech
,
Program Chairs:
Gultekin Ozsoyoglu
Case Western Reserve University
,
Armin Mikler
University of North Texas

Copyright © 2010 ACM.

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Published: 02 August 2010

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BCB'10: ACM International Conference on Bioinformatics and Computational Biology

August 2 - 4, 2010

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Cited By

Yanover CBradley P(2011)Large-scale characterization of peptide-MHC binding landscapes with structural simulationsProceedings of the National Academy of Sciences10.1073/pnas.1018165108108:17(6981-6986)Online publication date: 8-Apr-2011
https://doi.org/10.1073/pnas.1018165108

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