cyano 4’ methyl phenylbenzene, a key intermediate of Sartan drug, was synthesized from 4 bromotoluene and 2 bromobenzonitrile in the present of cuprous bromide as a catalyst. The yield is 50%.
以溴亚铜为催
剂,将邻苯
腈与对溴
苯偶联制备了合成沙坦类药物的关键中间体2氰
4′
联苯,收率50%。