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炔诺酮

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炔诺酮
臨床資料
商品名英语Drug nomenclatureAlone: Aygestin, Camila, Heather, Micronor, Primolut N, others; With EE: Lo Loestrin, Loestrin, Microgestin, Modicon, Norinyl, Ortho-Novum, others; With E2: Activella, Activelle, Estalis, Kliogest, Necon, Novofem, Trisequens, others
其他名稱NET; Norethindrone; NSC-9564; LG-202; Ethinylnortestosterone; Norpregneninolone; Anhydrohydroxy-norprogesterone; Ethinylestrenolone; 17α-Ethynyl-19-nortestosterone; 17α-Ethynylestra-4-en-17β-ol-3-one; 17α-Hydroxy-19-norpregn-4-en-20-yn-3-one
AHFS/Drugs.com国际药品名称
MedlinePlusa604034
给药途径By mouth, intramuscular injection (as NETE)
藥物類別英语Drug classProgestin; Progestogen
ATC碼
藥物動力學數據
生物利用度47–73% (mean 64%)[1][2]
血漿蛋白結合率97%:
Albumin: 61%;
SHBG: 36%
药物代谢Mainly CYP3A4 (liver);[3] also 5α-/5β-reductase, 3α-/3β-HSD, and aromatase
生物半衰期5.2–12.8 hours (mean 8.0 hours)[1]
识别信息
  • (8R,9S,10R,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,6,7,8,9,10,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one
CAS号68-22-4  checkY
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard英语CompTox Chemicals Dashboard (EPA)
ECHA InfoCard100.000.619 編輯維基數據鏈接
化学信息
化学式C20H26O2
摩尔质量298.419 g/mol
3D模型(JSmol英语JSmol
熔点203至204 °C(397至399 °F)
  • C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@]2(C#C)O)CCC4=CC(=O)CC[C@H]34
  • InChI=1S/C20H26O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,12,15-18,22H,4-11H2,2H3/t15-,16+,17+,18-,19-,20-/m0/s1 checkY
  • Key:VIKNJXKGJWUCNN-XGXHKTLJSA-N checkY

炔诺酮(英語:Norethisterone 或 英語:norethindrone)是一种黄体制剂药物,用做口服避孕药激素替代療法药物以及治疗一些妇科疾病[4]

另见

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参考文献

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  1. ^ 1.0 1.1 Stanczyk, Frank Z. Pharmacokinetics and Potency of Progestins used for Hormone Replacement Therapy and Contraception (PDF). Reviews in Endocrine and Metabolic Disorders. Sep 2002, 3 (3): 211–224. ISSN 1389-9155. PMID 12215716. doi:10.1023/A:1020072325818. 
  2. ^ Fotherby K. Bioavailability of orally administered sex steroids used in oral contraception and hormone replacement therapy. Contraception. August 1996, 54 (2): 59–69. PMID 8842581. doi:10.1016/0010-7824(96)00136-9. 
  3. ^ Korhonen T, Turpeinen M, Tolonen A, Laine K, Pelkonen O. Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J. Steroid Biochem. Mol. Biol. 2008, 110 (1–2): 56–66. PMID 18356043. doi:10.1016/j.jsbmb.2007.09.025. 
  4. ^ Kathryn Rhodes Alden; Deitra Leonard Lowdermilk; Mary Catherine Cashion; Shannon E. Perry. Maternity and Women's Health Care - E-Book. Elsevier Health Sciences. 27 December 2013: 135– [2019-06-30]. ISBN 978-0-323-29368-6. (原始内容存档于2020-01-04).