Qure

182 and counting. Two scientists found an unusual cannabinoid in hemp for the first time. The study is a preprint, but the two authors used a selective method of separating compounds called flash chromatography. Doing so allegedly prevented the loss of water during analysis. Dr. E. Michael Thurman and Imma Ferrer found a form of CBD with a double-bond missing from the methylene group between the eighth and ninth position. The compound instead contains an additional hydroxyl (OH) group, which means this is a hydrated variant of CBD. [Remember: Hydration ≠ Hydrogenation] The authors identified the compound as epiCBD-hydrate. Although, it’s difficult to tell how the compound would affect humans without biological tests. CBD, as a molecule, contains two major portions: The limonene half and the olivetol piece. The ‘limonene half’ of CBD is responsible for quinone formation and the eventual purple color formation. This newly identified form of hydrated CBD has an olivetol piece and an a-terpineol half. The team used flash chromatography to find the compound in hemp cultivars from Boulder, Colorado. They employed liquid chromatography coupled to quadrupole time- of-flight mass spectrometry (LC/Q-TOF-MS) to analyze the exact mass of the compound. The authors also used tandem mass spectrometry and NMR to identify epiannabidiol-hydrate in hemp. As far I understand - normal procedures induce enough heat to break the bond holding onto the +OH group, which leaves behind a hydrogen atom with an extra electron (H-). | [OH + H = H2O] The freed electron moves into the molecule. The position of the rearranged ion essentially destroys the original cannabinoid (epiCBD-hydrate) and forms a different isomer of CBD. The paper noted that they found other isomers and COOH analogues in various hemp products. Did hydration simply occur in the experiment, given the use of water in the mobile phase? Or does this preprint document the authentic discovery of a hydrated cannabinoid from multiple hemp samples? I am not a chemist or engineer myself, so please leave a comment if you have better insight >>>

𝐓𝐡𝐞 𝐅𝐮𝐭𝐮𝐫𝐞 𝐨𝐟 𝐇𝐞𝐚𝐥𝐭𝐡𝐜𝐚𝐫𝐞: 𝐇𝐨𝐰 𝐏𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐌𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐢𝐬 𝐂𝐡𝐚𝐧𝐠𝐢𝐧𝐠 𝐓𝐡𝐞 𝐆𝐚𝐦𝐞 📚 𝐋𝐚𝐬𝐭 𝐨𝐩𝐩𝐨𝐫𝐭𝐮𝐧𝐢𝐭𝐲 𝐭𝐨 𝐝𝐨𝐰𝐧𝐥𝐨𝐚𝐝 𝐏𝐃𝐅 𝐛𝐫𝐨𝐜𝐡𝐮𝐫𝐞: https://lnkd.in/d4j-4aaw #Precision_medicine, also known as personalized medicine, is an approach to medical care and treatment that takes into account individual variability in genes, environment, and lifestyle for each person. The goal of precision medicine is to tailor medical decisions, interventions, and treatments to the specific characteristics of each patient, rather than adopting a one-size-fits-all approach. Traditional medicine often relies on general guidelines and population-based treatments, which might not be effective for every individual due to differences in genetics, metabolism, and other factors. Precision medicine aims to address this limitation by considering a person's unique genetic makeup, molecular profiles, and other personal information to provide more accurate diagnoses, treatment plans, and disease prevention strategies. 📢 𝐊𝐞𝐲 𝐜𝐨𝐦𝐩𝐨𝐧𝐞𝐧𝐭𝐬 𝐨𝐟 𝐩𝐫𝐞𝐜𝐢𝐬𝐢𝐨𝐧 𝐦𝐞𝐝𝐢𝐜𝐢𝐧𝐞 𝐢𝐧𝐜𝐥𝐮𝐝𝐞: ✅ Genomics: This involves studying an individual's genetic information, such as DNA sequences, to identify genetic variations that might contribute to diseases or affect how an individual responds to specific treatments. ✅ Molecular Profiling: Precision medicine also involves analyzing various molecules in the body, such as proteins, metabolites, and RNA, to understand disease mechanisms and tailor treatments accordingly. ✅ Data Integration: Precision medicine relies on a comprehensive approach that incorporates various types of data, including clinical, genetic, environmental, and lifestyle information, to create a more holistic picture of an individual's health. ✅ Targeted Therapies: With the insights gained from genetic and molecular profiling, healthcare providers can develop targeted therapies that address the specific genetic mutations or molecular pathways driving a patient's disease. This approach often leads to more effective and less harmful treatments. ✅ Disease Prevention: Precision medicine not only focuses on treatment but also on disease prevention. By identifying individuals at higher risk of certain conditions, interventions can be designed to prevent the onset of diseases or catch them at an early, more treatable stage. ✅ Data and Technology: Precision medicine heavily relies on advanced technologies, including high-throughput sequencing, bioinformatics, and data analysis tools, to process and interpret vast amounts of patient data.

Ph.Eur. monograph 3151 for Cannabidiol isolate is finally out.

// UNITS & PROPORTIONS When we measure the presence of a compound in a sample, we usually work with concentrations, or proportions. In the case of using a specific unit (milligram), as long as we compare it to the same root unit (gram), the answer is a proportion and can be shown in % simply by multiplying by the relevant power of 10 (eg. 50 mg/g = 5% or 50 g/kg = 5% or 50 ml/l = 5% or 50 mg/kg = 0.005%). However, for liquid samples, you sometimes want to know the presence of a compound in milligram (a unit of mass) per milliliter (a unit of volume) of the sample. This is not a simple proportion and requires that you know the density of the liquid. And unless the density is exactly 1g/ml, converting the result to a percentage is not merely as simple as decreasing by a factor of 10. These are the units you can expect in our COAs: mg/g & % = potency, cannabinoids and terpenes mg/ml = potency, cannabinoids & terpenes on liquid samples where a density measurement was performed g/ml = density % = moisture content and total ash cfu/g = microbial content (colony forming units per gram) ppm = residual solvents µg/kg (ppb) = heavy metals mg/kg (ppm) = mycotoxins and pesticides Thank goodness for the metric system! #areyouqurious #knowingisgrowing

I thought I'd share a condensed summary of some trials we have conducted over the course of the last year. The results speak for themselves and highlight the fact that Yofumo's patented ozone decontamination technology is indeed a viable alternative to radiation. In our 2022 whitepaper, we conducted an experiment in which we spiked samples with E-Coli, Salmonella, Pseudomonas & Aspergillus. The table shows the results pre-spike (control), post-spike and post decontamination treatment. We used Brenda Marx and Qure for all our testing on this one and are proud to associate ourselves with their high standards and dedication to the cannabis plant. The other trials listed were done with an assortment of South African producers (and their preferred labs) in which they first provided us with a COA and based on such, the appropriate treatment times were calculated by Yofumo. Post treatment, samples were then sent to the same SAHPRA approved labs who provided the initial pre-treatment COA's. A point to note is that although this table concentrates on micro testing alone, we have other independently validated documentation that shows our technology has no impact on terpene or cannabinoid profiles even when treatment times of 50 hours have been utilized and the correct post treatment protocols have been followed. Interested parties are of course welcome to DM me for further details and also to arrange either trial or treatment. #cannabis #cannabismedicinal #cannabisscience #cannabiscompliance #cannabisresearch #cannabissafety #healthandsafety #consumersafety