Von Willebrand factor (Q412310)

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mammalian protein found in Homo sapiens
  • VWF
  • coagulation factor VIII VWF
  • uniprot:P04275
  • von Willebrand factor
edit
Language Label Description Also known as
English
Von Willebrand factor
mammalian protein found in Homo sapiens
  • VWF
  • coagulation factor VIII VWF
  • uniprot:P04275
  • von Willebrand factor

Statements

molecular function
protein binding
determination method or standard
IDA
IPI
11 references
retrieved
8 April 2019
stated in
Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
A single high-affinity binding site for von Willebrand factor in collagen III, identified using synthetic triple-helical peptides
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Evidence that the primary binding site of von Willebrand factor that mediates platelet adhesion on subendothelium is not collagen
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Allosteric activation of ADAMTS13 by von Willebrand factor.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Crystal structure of the wild-type von Willebrand factor A1-glycoprotein Ibalpha complex reveals conformation differences with a complex bearing von Willebrand disease mutations
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Factor VIII accelerates proteolytic cleavage of von Willebrand factor by ADAMTS13.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
ADAMTS13 substrate recognition of von Willebrand factor A2 domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutations C1157F and C1234W of von Willebrand factor cause intracellular retention with defective multimerization and secretion
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IDA
extracellular matrix structural constituent
determination method or standard
IEA
RCA
6 references
retrieved
1 January 2018
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
RCA
retrieved
1 January 2018
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
RCA
retrieved
1 January 2018
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
RCA
retrieved
1 January 2018
stated in
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IEA
retrieved
1 January 2018
stated in
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IEA
retrieved
1 January 2018
stated in
SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IEA
cell component
extracellular region
determination method or standard
NAS
IDA
TAS
IEA
5 references
retrieved
17 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275
determination method or standard
TAS
retrieved
17 October 2017
stated in
The human plasma proteome: a nonredundant list developed by combination of four separate sources
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275
determination method or standard
NAS
retrieved
17 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275
determination method or standard
IEA
retrieved
17 October 2017
stated in
A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275
determination method or standard
IDA
retrieved
17 October 2017
stated in
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P04275&geneProductId=UniProtKB:P04275
determination method or standard
IDA
extracellular region
determination method or standard
HDA
IDA
IEA
NAS
TAS
5 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
TAS
retrieved
8 April 2019
stated in
The human plasma proteome: a nonredundant list developed by combination of four separate sources
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
NAS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IEA
retrieved
8 April 2019
stated in
A novel von Willebrand disease-causing mutation (Arg273Trp) in the von Willebrand factor propeptide that results in defective multimerization and secretion
GOA
curator
UniProt
UniProt protein ID
P04275
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
IDA
retrieved
8 April 2019
stated in
Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04275
determination method or standard
HDA
biological process
Gene Atlas image
PBB GE VWF 202112 at fs.png
732 × 530; 11 KB
0 references
Commons category
Von willebrand factor
0 references

Identifiers

ATC code
B02BD10
0 references
MeSH descriptor ID
D014841
subject named as
Von Willebrand factor
0 references
MeSH tree code
D12.776.124.125.920
0 references
D23.119.985
0 references
Microsoft Academic ID
2779394231
0 references
2908911547
0 references
PDB structure ID
 
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