MDM2 proto-oncogene (Q2639180)

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mammalian protein found in Homo sapiens
  • MDM2 proto-oncogene, E3 ubiquitin protein ligase
  • Hdm2
  • E3 ubiquitin-protein ligase Mdm2
  • MDM2
  • double minute 2, human homolog of; p53-binding protein
  • Mdm2, p53 E3 ubiquitin protein ligase homolog
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
  • oncoprotein Mdm2
  • MDM2 oncogene, E3 ubiquitin protein ligase
  • Double minute 2 protein
  • p53-binding protein Mdm2
  • Proto-Oncogene Proteins c-mdm2
edit
Language Label Description Also known as
English
MDM2 proto-oncogene
mammalian protein found in Homo sapiens
  • MDM2 proto-oncogene, E3 ubiquitin protein ligase
  • Hdm2
  • E3 ubiquitin-protein ligase Mdm2
  • MDM2
  • double minute 2, human homolog of; p53-binding protein
  • Mdm2, p53 E3 ubiquitin protein ligase homolog
  • Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
  • oncoprotein Mdm2
  • MDM2 oncogene, E3 ubiquitin protein ligase
  • Double minute 2 protein
  • p53-binding protein Mdm2
  • Proto-Oncogene Proteins c-mdm2

Statements

molecular function
protein binding
determination method or standard
IPI
114 references
retrieved
8 April 2019
stated in
Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
PML regulates p53 stability by sequestering Mdm2 to the nucleolus
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Repression of p53-mediated transcription by MDM2: a dual mechanism
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Monoubiquitylation promotes mitochondrial p53 translocation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cellular stress and DNA damage invoke temporally distinct Mdm2, p53 and PML complexes and damage-specific nuclear relocalization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Vimentin is a novel AKT1 target mediating motility and invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of XIAP translation and induction by MDM2 following irradiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
RYBP stabilizes p53 by modulating MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM-mediated serine 72 phosphorylation stabilizes ribonucleotide reductase small subunit p53R2 protein against MDM2 to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
EBV-encoded EBNA-5 associates with P14ARF in extranucleolar inclusions and prolongs the survival of P14ARF-expressing cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
DNA-damage-responsive acetylation of pRb regulates binding to E2F-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inhibition of Thr-55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
An essential function of the extreme C-terminus of MDM2 can be provided by MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A "twist box" code of p53 inactivation: twist box: p53 interaction promotes p53 degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
14-3-3 Binding to Pim-phosphorylated Ser166 and Ser186 of human Mdm2--Potential interplay with the PKB/Akt pathway and p14(ARF)
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDMX regulation of p53 response to ribosomal stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
JMJD6 promotes colon carcinogenesis through negative regulation of p53 by hydroxylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of nucleolar signalling to p53 through NEDDylation of L11
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Characterization of an E1A-CBP interaction defines a novel transcriptional adapter motif (TRAM) in CBP/p300
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
beta-arrestin 2 oligomerization controls the Mdm2-dependent inhibition of p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
NUMB controls p53 tumour suppressor activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular recognition of p53 and MDM2 by USP7/HAUSP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Specific domains of nucleolin interact with Hdm2 and antagonize Hdm2-mediated p53 ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Acetylation is indispensable for p53 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
PACT is a negative regulator of p53 and essential for cell growth and embryonic development
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
FKBP25, a novel regulator of the p53 pathway, induces the degradation of MDM2 and activation of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
S100 proteins interact with the N-terminal domain of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Interaction between the retinoblastoma protein and the oncoprotein MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Proteasome activator PA28 gamma regulates p53 by enhancing its MDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Negative regulation of p53 functions by Daxx and the involvement of MDM2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A beta-arrestin 2 signaling complex mediates lithium action on behavior
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The HBx protein of hepatitis B virus confers resistance against nucleolar stress and anti-cancer drug-induced p53 expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Critical role for Daxx in regulating Mdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
HDM2-binding partners: interaction with translation elongation factor EF1alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Inactivation of the p53 pathway in retinoblastoma.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Stra13 is induced by genotoxic stress and regulates ionizing-radiation-induced apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The central region of HDM2 provides a second binding site for p53.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein S27-like and S27 interplay with p53-MDM2 axis as a target, a substrate and a regulator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mdm2 targets the p53 transcription cofactor JMY for degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A newly identified Pirh2 substrate SCYL1-BP1 can bind to MDM2 and accelerate MDM2 self-ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Induction of SOX4 by DNA damage is critical for p53 stabilization and function
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mutational analysis reveals a dual role of Mdm2 acidic domain in the regulation of p53 stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF-dependent regulation of ATM and p53 associated KZNF (Apak) protein activity in response to oncogenic stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
p14ARF interacts with DAXX: effects on HDM2 and p53
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Regulation of p53 stability and function by the deubiquitinating enzyme USP42
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
p53 mediates the negative regulation of MDM2 by orphan receptor TR3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Efficient p53 activation and apoptosis by simultaneous disruption of binding to MDM2 and MDMX
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
MDM2 enhances the function of estrogen receptor alpha in human breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Molecular basis of the interactions between the p73 N terminus and p300: effects on transactivation and modulation by phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
A CDKN2A mutation in familial melanoma that abrogates binding of p16INK4a to CDK4 but not CDK6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
BIRC7–E2 ubiquitin conjugate structure reveals the mechanism of ubiquitin transfer by a RING dimer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
SUMOylation of hnRNP-K is required for p53-mediated cell-cycle arrest in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Nucleolar protein NPM interacts with HDM2 and protects tumor suppressor protein p53 from HDM2-mediated degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
p53 binding
determination method or standard
IEA
IPI
5 references
retrieved
8 April 2019
stated in
RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Functional interplay between MDM2, p63/p73 and mutant p53
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
Phosphorylation on Thr-55 by TAF1 mediates degradation of p53: a role for TAF1 in cell G1 progression
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IPI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
ubiquitin protein ligase activity
determination method or standard
IDA
IEA
IMP
TAS
7 references
retrieved
7 November 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
TAS
retrieved
7 November 2018
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
7 November 2018
stated in
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
7 November 2018
stated in
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
7 November 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
7 November 2018
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
7 November 2018
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q00987&geneProductId=UniProtKB:Q00987
determination method or standard
IDA
ubiquitin protein ligase activity
determination method or standard
IDA
IEA
IMP
6 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
cell component
nucleus
determination method or standard
IDA
IEA
IMP
7 references
retrieved
8 April 2019
stated in
Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
Regulation of the Mdm2-p53 pathway by the ubiquitin E3 ligase MARCH7.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
protein-containing complex
determination method or standard
IDA
IMP
5 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Defining the molecular basis of Arf and Hdm2 interactions
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
biological process
protein ubiquitination
determination method or standard
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
{beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Daxx is reciprocally regulated by Mdm2 and Hausp
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
protein destabilization
determination method or standard
IDA
IMP
5 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
ubiquitin-dependent protein catabolic process
determination method or standard
IDA
IEA
IGI
IMP
9 references
retrieved
8 April 2019
stated in
Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Cooperation between the ribosomal proteins L5 and L11 in the p53 pathway
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IMP
retrieved
8 April 2019
stated in
Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IEA
retrieved
8 April 2019
stated in
A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2
GOA
curator
UniProt
UniProt protein ID
Q00987
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA
retrieved
8 April 2019
stated in
Stabilization and activation of p53 by the coactivator protein TAFII31
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q00987
determination method or standard
IDA

Identifiers

Ensembl protein ID
PDB structure ID
 
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