Arginine vasopressin receptor 2 (Q4789588)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30518

G protein-coupled receptor

1 reference

Transporter Classification Database ID

9.A.14.10.3

hierarchical database ID heuristic

2 October 2019

based on heuristic

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

1 reference

27 March 2018

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

1 reference

27 March 2018

protein binding

vasopressin receptor activity

IPI

vasopressin receptor activity

Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

integral component of membrane

cell component

Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

endosome

1 reference

8 April 2019

Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

Golgi apparatus

1 reference

8 April 2019

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

1 reference

8 April 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

3 references

8 April 2019

8 April 2019

Pharmacological chaperones rescue cell-surface expression and function of misfolded V2 vasopressin receptor mutants

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

integral component of plasma membrane

1 reference

27 March 2018

Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

endoplasmic reticulum

1 reference

8 April 2019

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

clathrin-coated vesicle membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

1 reference

8 April 2019

integral component of plasma membrane

1 reference

8 April 2019

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

excretion

1 reference

8 April 2019

Mutations in the V2 vasopressin receptor gene are associated with X-linked nephrogenic diabetes insipidus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

Vasopressin-induced von Willebrand factor secretion from endothelial cells involves V2 receptors and cAMP

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

regulation of systemic arterial blood pressure by vasopressin

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

activation of adenylate cyclase activity

1 reference

8 April 2019

Palmitoylation of the V2 vasopressin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

response to peptide

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

1 reference

27 March 2018

cellular response to hormone stimulus

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

positive regulation of vasoconstriction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

renal water homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

1 reference

8 April 2019

positive regulation of protein ubiquitination

NAS

1 reference

8 April 2019

Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5

GOA

curator

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

NAS

signal transduction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

1 reference

8 April 2019

membrane organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

1 reference

8 April 2019

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

27 March 2018

positive regulation of gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P30518&geneProductId=UniProtKB:P30518

1 reference

27 March 2018

positive regulation of systemic arterial blood pressure

ISS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

I-kappaB kinase/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

positive regulation of cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

telencephalon development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

response to cytokine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

negative regulation of urine volume

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

negative regulation of renal sodium excretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

positive regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P30518

physically interacts with

1 reference

2169

17 August 2016

2 references

2174

English

17 August 2016

2176

17 August 2016

1 reference

2168

17 August 2016

1 reference

2203

17 August 2016

1 reference

2202

17 August 2016

1 reference

2200

17 August 2016

1 reference

2226

17 August 2016

1 reference

2238

17 August 2016

1 reference

2197

English

17 August 2016

mozavaptan

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL420762

arginine vasopressin

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL373742

desmopressin

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL376685

LVP

agonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200690

conivaptan hydrochloride

antagonist

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201108

has part(s)

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P30518

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

13 January 2016

http://www.uniprot.org/uniprot/P30518.txt?version=172

Transporter Classification Database ID

9.A.14.10.3

2 references

Transporter Classification database

13 March 2020

Transporter Classification database