cytochrome P450 family 2 subfamily C member 19 (Q3737532)

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mammalian protein found in Homo sapiens

cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19
flavoprotein-linked monooxygenase
CYPIIC17
S-mephenytoin 4-hydroxylase
(R)-limonene 6-monooxygenase
cytochrome P450-254C
microsomal monooxygenase
1.14.13.80
xenobiotic monooxygenase
mephenytoin 4'-hydroxylase
(S)-limonene 6-monooxygenase
mephenytoin 4-hydroxylase
1.14.13.48
CYP2C19
fenbendazole monooxygenase (4'-hydroxylating)
(S)-limonene 7-monooxygenase
CYPIIC19
1.14.13.49
cytochrome P450, family 2, subfamily C, polypeptide 19
cytochrome P450 2C19
cytochrome P450-11A
cytochrome P-450 II C
Cytochrome P-450 CYP2C19

Language	Label	Description	Also known as
English	cytochrome P450 family 2 subfamily C member 19	mammalian protein found in Homo sapiens	cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19 flavoprotein-linked monooxygenase CYPIIC17 S-mephenytoin 4-hydroxylase (R)-limonene 6-monooxygenase cytochrome P450-254C microsomal monooxygenase 1.14.13.80 xenobiotic monooxygenase mephenytoin 4'-hydroxylase (S)-limonene 6-monooxygenase mephenytoin 4-hydroxylase 1.14.13.48 CYP2C19 fenbendazole monooxygenase (4'-hydroxylating) (S)-limonene 7-monooxygenase CYPIIC19 1.14.13.49 cytochrome P450, family 2, subfamily C, polypeptide 19 cytochrome P450 2C19 cytochrome P450-11A cytochrome P-450 II C Cytochrome P-450 CYP2C19

Statements

1 reference

13 November 2019

UniProt protein ID

cytochrome P450 superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33261

cytochrome P450, E-class, group I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33261

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

iron ion binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

determination method or standard

1 reference

8 April 2019

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

arachidonic acid epoxygenase activity

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

monooxygenase activity

determination method or standard

3 references

8 April 2019

Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

steroid hydroxylase activity

determination method or standard

1 reference

5 June 2018

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33261&geneProductId=UniProtKB:P33261

determination method or standard

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

determination method or standard

1 reference

8 April 2019

Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b(5) enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

oxidoreductase activity

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Acetaminophen bioactivation by human cytochrome P450 enzymes and animal microsomes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

steroid hydroxylase activity

determination method or standard

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Structural characterization of human cytochrome P450 2C19: active site differences between P450s 2C8, 2C9, and 2C19

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

organelle membrane

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

endoplasmic reticulum

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

intracellular membrane-bounded organelle

determination method or standard

3 references

8 April 2019

Genetic polymorphism of human cytochrome P-450 (S)-mephenytoin 4-hydroxylase. Studies with human autoantibodies suggest a functionally altered cytochrome P-450 isozyme as cause of the genetic deficiency

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

biological process

steroid metabolic process

determination method or standard

1 reference

8 April 2019

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

omega-hydroxylase P450 pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

heterocycle metabolic process

determination method or standard

1 reference

8 April 2019

Hepatic cytochrome P450 enzyme alterations in humans with progressive stages of nonalcoholic fatty liver disease

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

monoterpenoid metabolic process

determination method or standard

1 reference

8 April 2019

Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

xenobiotic metabolic process

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P33261&geneProductId=UniProtKB:P33261

determination method or standard

organic acid metabolic process

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P33261

determination method or standard

EC enzyme number

1.14.14.51

1 reference

9 September 2019

Gene Atlas image

PBB GE CYP2C19 216058 s at fs.png
732 × 530; 12 KB

0 references

cytochrome P450, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P33261

Identifiers

MeSH descriptor ID

subject named as

Cytochrome P-450 CYP2C19

0 references

D08.244.453.491.500.700

0 references

D08.811.682.690.708.170.450.500.700

0 references

D12.776.422.220.453.491.500.700

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Encyclopedia of China (Third Edition) ID

0 references

Ensembl protein ID

ENSP00000360372

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000360372

ENSP00000483847

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483847

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(12 entries)

arwiki سيتوكروم 2C19
cywiki CYP2C19
dewiki Cytochrom P450 2C19
enwiki CYP2C19
eswiki CYP2C19
etwiki Tsütokroom P450 2C19
fawiki CYP2C19
jawiki CYP2C19
kowiki CYP2C19
nlwiki CYP2C19
ukwiki CYP2C19
zhwiki CYP2C19

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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