Medications Used to Treat Eating Disorders

Recovery from an eating disorder is challenging. If you or a loved one has an eating disorder, you may be wondering: Can medication help? The answer is complicated.

For eating disorders, food (and the normalization of eating patterns) is the primary medicine. This is combined with therapy to help distorted thoughts (or unhelpful thoughts) surrounding food, weight, eating, and body image.

In some cases, psychiatric medication (such as antidepressants, antipsychotics, or mood stabilizers) can make therapy more successful. Many people with eating disorders also struggle with anxiety and depression and medication may help with those symptoms.

A thorough diagnostic evaluation with a psychiatrist is always recommended before beginning any regimen of psychiatric medication. Among other things, it is essential to determine whether anxiety and mood symptoms came before the eating disorder or could be symptoms of malnutrition.

Anorexia Nervosa

Medication should generally not be the initial or primary treatment for anorexia nervosa. While some success has been shown with pharmacological treatment for bulimia and binge eating disorder, there is far more evidence supporting nutritional rehabilitation and psychotherapy for treating anorexia nervosa, compared with medication.

Typically, when medication is prescribed, the primary goal tends to be weight gain or to treat the anxiety or depressive symptoms that may co-occur with the anorexia. It is often prescribed for patients who have under-responded to nutritional restoration and psychotherapy.

However, even in these cases, the efficacy of medication has not been well studied—treatment trials are considered challenging to conduct on patients with anorexia because these patients tend to be reluctant to take medication for fear of weight gain.

Antipsychotics for Anorexia

There is some limited evidence that second-generation antipsychotic medications (also called atypical antipsychotics), such as Zyprexa (olanzapine), can help lead to small weight increases. However, the mechanism by which these may work is not well understood.

Interestingly, even though patients with anorexia often have significantly distorted views of food and their bodies that are similar to psychotic delusions, these symptoms do not appear to respond to antipsychotic medications.

Antidepressants for Anorexia

Antidepressant medications typically do not help with weight gain, although they can be used to treat co-occurring anxiety and depression. Unfortunately, many medications do not seem to work well in patients with anorexia nervosa. This may be because starvation affects the function of neurotransmitters in the brain.

Benzodiazepines for Anorexia

Sometimes, benzodiazepines may be prescribed for use before meals to reduce anxiety. However, no research supports this practice, and benzodiazepines can become addictive.

Oral Contraceptives for Anorexia

Patients with anorexia nervosa are at risk for bone weakness (osteopenia and osteoporosis) and increased fractures due to malnutrition. This is often accompanied by the loss of a menstrual period (menses). Doctors commonly prescribe birth control pills in an attempt to restart menses and minimize bone weakness.

Research reminds us that low bone density is best treated with weight restoration, which is, at this time, the only known way to normalize the hormones that contribute to bone weakening.

Bulimia Nervosa

Psychiatric medications have been shown to be helpful for the treatment of bulimia nervosa and are most often used in addition to nutritional rehabilitation and psychotherapy. Nutritional restoration is focused on establishing regular and structured meals.

Medication alone is not usually recommended for bulimia nervosa unless a patient does not have access to psychotherapy and nutrition therapy.

SSRIs for Bulimia

A primary goal of treatment for bulimia nervosa is stopping the bingeing and purging. Selective serotonin reuptake inhibitors (SSRI antidepressants) are the most studied medication for the treatment of bulimia nervosa and are generally well-tolerated by patients.

It is not yet known exactly why they work; however, it is hypothesized that in at least some patients the serotonin pathways in the brain are disturbed. This class of antidepressants has been shown to reduce binge eating, purging, and psychological symptoms such as the drive for thinness. This class of medications has demonstrated helpfulness in improving co-occurring symptoms of anxiety and depression.

Of the SSRIs, Prozac (the commercial name for fluoxetine) is the most studied for the treatment of bulimia nervosa, and it is also the only medication specifically approved by the U.S. Food and Drug Administration(FDA) for adults with bulimia nervosa. For these reasons, it is often recommended as the first medication to try.

Research shows that if a patient with bulimia nervosa responds well to Prozac, they will likely show a positive response within three weeks of taking the medication. It is important to note that multiple randomized control trials have established 60 mg of Prozac as the standard dose for bulimia nervosa. This is higher than the standard dose used for major depression (40 mg).

If Prozac does not work, other SSRIs are often tried next. It is not uncommon for other agents, such as the anticonvulsant topiramate, to be used off-label for bulimia. It is generally recommended that patients stay on medication for 6 to 12 months after achieving improvement on the medication.

Binge Eating Disorder

Medications seem effective in helping patients with binge eating disorder (BED) stop the binge eating episodes but do not generally produce the weight loss that is a common goal for patients seeking help for this disorder.

For BED, three main classes of medications have been studied: antidepressants (primarily the SSRIs, including Prozac); antiseizure medications, especially Topamax (topiramate); and Vyvanse (lisdexamfetamine).

Antidepressants for BED

As they do for patients with bulimia nervosa, antidepressants can help reduce the frequency of binge eating in patients with BED. They can also help to reduce obsessive thoughts and symptoms of depression. Topiramate can also help reduce the frequency of binges and may also reduce obsessive thoughts and impulsivity.

Stimulants for BED

Stimulant medications used in treating attention deficit hyperactivity disorder (ADHD) are noted to suppress appetite and so have been a recent focus of attention for treating BED.

Vyvanse (lisdexamfetamine), an ADHD medication, became the first medication approved by the FDA for treating BED. It has been studied in three trials and was associated with reduced binge episodes per week, decreased eating-related obsessions and compulsions, and produced small weight losses.

Warning About Wellbutrin

The antidepressant bupropion (often marketed as Wellbutrin) is often prescribed to patients who are trying to lose weight and who may also exhibit depressive symptoms. Wellbutrin has been associated with seizures in patients with purging bulimia, however, and is not recommended for patients with eating disorders.

Summary

In general, medication is not typically the primary mode of treatment for an eating disorder. Medication may be helpful when added to psychotherapy or when psychotherapy is not available. Further, medication is often used when patients also have symptoms of anxiety and depression to help with these symptoms.

However, medications can carry a risk for side effects that are not found with psychological therapies. Ultimately, the “medication” of choice for an eating disorder is food and normal eating as well as finding a way to cope with the unhelpful or distorted thoughts surrounding food, eating, and body image.

There are various treatments for eating disorders that are considered efficacious, including cognitive behavioral therapy and family-based treatment.