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KAMPALA INTERNATIONAL UNIVERSITY-
WC
DEPARTMENT OF SURGERY
ADVANCED ANATOMY II
LIMBIC SYSTEM AND RETICULAR FORMATION
Lecturer:- Dr Abdifatah Abdi Ali
1
3/30/2023
outline
Introduction
Components
Functions
Lesions associate with disorders
2
3/30/2023
INTRODUCTION
Limbic system was a term loosely
used to describe the part of the
brain between the cerebral
cortex and the hypothalamus, a
little understood area of the
brain.
Today, it is
known to play a vital role in
emotion, behavior, memory and
olfaction.
3
3/30/2023
INTRODUCTION
 The term "limbic" is from the
Latin word Limbus, for
"border" or "edge“, it is also
means ring.
 It separates the medial
surface of the cerebral cortex
from the diencephalon
 It consists of a number of
cortical & subcortical
structures with looped
connections that all project to
the hypothalamus
4
3/30/2023
COMPONENTS
The limbic system is composed of:
Nuclei
Fiber bundles
5
3/30/2023
COMPONENTS: Nuclei
1. Limbic lobes: 3 parts:
Cingulate gyrus, Para-hippocampal
gyrus, Uncus
2. Hyppocampal formation:
hippocampus, Dentate gyrus
3. Mamillary body: Hypothalamus
4. Thalamus: Anterior nucleus,
Medial nucleus
5. Prefrontal cortex
6. Amygdaloid nucleus
7. Septal area
8. Habenular nucleus
6
3/30/2023
COMPONENTS: Nuclei
1. Limbic lobes: 3 parts:
Cingulate gyrus, Para-hippocampal
gyrus, Uncus
2. Hyppocampal formation:
hippocampus, Dentate gyrus
3. Mamillary body: Hypothalamus
4. Thalamus: Anterior nucleus, Medial
nucleus
5. Prefrontal cortex
6. Amygdaloid nucleus
7. Septal area
8. Habenular nucleus
7
3/30/2023
COMPONENTS: Nuclei
1. Limbic lobes: 3 parts:
Cingulate gyrus, Para-hippocampal
gyrus, Uncus
2. Hyppocampal formation:
hippocampus, Dentate gyrus
3. Mamillary body: Hypothalamus
4. Thalamus: Anterior nucleus, Medial
nucleus
5. Prefrontal cortex
6. Amygdaloid nucleus
7. Septal area
8. Habenular nucleus
8
3/30/2023
COMPONENTS: Nuclei
1. Limbic lobes: 3 parts:
Cingulate gyrus, Para-
hippocampal gyrus, Uncus
2. Hyppocampal formation:
hippocampus, Dentate gyrus
3. Mamillary body:
Hypothalamus
4. Thalamus: Anterior nucleus,
Medial nucleus
5. Prefrontal cortex
6. Amygdaloid nucleus
7. Septal area
8. Habenular nucleus
9
3/30/2023
COMPONENTS: Fiber bundles
Connection between
Nucleis
Fiber bundle
Limbic lobe Cingulum
Hippocampus/Mamillary body Fornix
Mamillary body/Anterior thalamic
nucleus
Mamillothalamic tract
Medial thalamic nucleus/Prefrontal cortex Antero thalamic radiation
Amygdaloid nucleus/septal area Stria terminalis
Septal area/habernular nucleus Stria medullaris thalami
10
3/30/2023
11
3/30/2023
LIMBIC SYSTEM
 components structures: limbic
cortex(lobes), amygdala, Hippocampus
and septal area.
The structures form connections
between the limbic system and the
hypothalamus, thalamus and cerebral
cortex
The hippocampus ( in memory and
learning), the limbic system( in the
control of the emotional responses).
12
3/30/2023
LIMBIC SYSTEM
Cortical structures: Limbic lobe,
Hippocampal formation, Septal
areas(fornix connecting the
hippocampus with mammillary bodies
and septal nuclei and prefrontal
area(olfactory cortex)
13
3/30/2023
LIMBIC SYSTEM
Limbic lobe:
C-shaped ring of Grey matter on
the medial side of each cerebral
hemisphere, surrounding the
corpus callosum.
It includes: subcollosal area,
cingulate gyrus, isthmus,
parahippocampal, uncus
14
3/30/2023
LIMBIC SYSTEM
Hippocampus: it is a limbic
system structure that involved in
FOS( formation organization and
storage of memories), important
in forming new memories and
connecting, emotions and senses
such as smell and sound , to
memories paired structures in
each cerebral hemisphere.
It is as a memory indexer by
sending memories to the
appropriate part of the cerebral
hemisphere for long-term storage
and retrieving them when
necessary
15
3/30/2023
LIMBIC SYSTEM
Hippocampus:
Site: scrolled ( infolding) structure
in the inferomedial part of the
temporal lobe
Fonction: memory(file new
memories as they occur)
The hippocampus connection are
necessary for consolidation of new
short term memoies
Its principal efferent pathway is
called the fornix(=it is C-shaped
group of fibers connecting the
hippocampus with mammillary
body, then to the anterior nuclei of
thalamus
16
3/30/2023
LIMBIC SYSTEM
Hippocampus(fornix):
Fornix is consist of 2 fimbria, 2
crus, 1 body and 2 column.
 the fornix is an important
component of PAPEZ
CIRCUIT(based on connecting
connecting the hypothalamus with
limbic lobe to control emotion
17
3/30/2023
LIMBIC SYSTEM
amygdale:
Site: almost shaped mass of nuclei that lies
near( deep within) the temporal pole, close
to the tail of the caudate nucleus.
Function, the amygdale is involved in
emotion, fear, anger, aggression, hormonal
secretion.
Connection of amygdale:
Inputs(association areas of visual, auditory
and somatosensory cortices),
Outputs(hypothalamus, autonomic nuclei in
the brain stem
Lesion of the amygdale : lack of emotional
responses and docility
18
3/30/2023
Functions of limbic system
It control a variety of functions including:
 Emotions,
 Emotional responses
 Behavior & Mood (happy, cry, laugh, sad, afraid, aggression,
depression)
 Motivation.
 Memory.
 Visceral & Motor responses involved in (sex, pleasure, hunger,
and reproduction).
 Olfaction.
19
3/30/2023
Lesions associated with limbic lobe disorders
 Korsakoff’s psychosis (Retrograde = loss of new memories at the
time of lesion with retained old memories & anterograde amnesia=
inability to gain new memories)
 Temporal lobe epilepsy
 The hippocampus is a common focus site in epilepsy, and can be
damaged through chronic seizures.
 It is sometimes damaged in diseases such as herpes encephalitis,
 Alzheimer’s disease: The hippocampus is one of the first brain areas to
show damage in Alzheimer's disease
 Schizophrenia.
 Lesion in the Amygdaloidal nucleus causes loss of aggressive
behavior, fear and anger
 Bilateral lesion of the amygdaloidal and hippocampus causes
increased appetite and abnormal hypersexual behavior
20
3/30/2023
21
3/30/2023
Lesions associate with reticular
formation
Lesions to major pathways of the reticular activating system can thus
impair consciousness and severe damage can cause:
 coma or a persistent vegetative state,
 Parkinson’s disease
 Schizophrenia
 Secondary brain injury
 Diffuse axona injury(DAI)
22
3/30/2023
REFERENCES
1. SNELL RS. Clinical Neuro-anatomy. 7th ed.
2. BRS Neuro-anatomy
3. Textbook of Anatomy : Head, Neck and Brain.
(Vishram Sing)(z-lib.org)
1. Netter’s Atlas of Human Anatomy 6th edition
2. Teach me anatomy.
23
3/30/2023

More Related Content

limbic system.pptx

  • 1. KAMPALA INTERNATIONAL UNIVERSITY- WC DEPARTMENT OF SURGERY ADVANCED ANATOMY II LIMBIC SYSTEM AND RETICULAR FORMATION Lecturer:- Dr Abdifatah Abdi Ali 1 3/30/2023
  • 3. INTRODUCTION Limbic system was a term loosely used to describe the part of the brain between the cerebral cortex and the hypothalamus, a little understood area of the brain. Today, it is known to play a vital role in emotion, behavior, memory and olfaction. 3 3/30/2023
  • 4. INTRODUCTION  The term "limbic" is from the Latin word Limbus, for "border" or "edge“, it is also means ring.  It separates the medial surface of the cerebral cortex from the diencephalon  It consists of a number of cortical & subcortical structures with looped connections that all project to the hypothalamus 4 3/30/2023
  • 5. COMPONENTS The limbic system is composed of: Nuclei Fiber bundles 5 3/30/2023
  • 6. COMPONENTS: Nuclei 1. Limbic lobes: 3 parts: Cingulate gyrus, Para-hippocampal gyrus, Uncus 2. Hyppocampal formation: hippocampus, Dentate gyrus 3. Mamillary body: Hypothalamus 4. Thalamus: Anterior nucleus, Medial nucleus 5. Prefrontal cortex 6. Amygdaloid nucleus 7. Septal area 8. Habenular nucleus 6 3/30/2023
  • 7. COMPONENTS: Nuclei 1. Limbic lobes: 3 parts: Cingulate gyrus, Para-hippocampal gyrus, Uncus 2. Hyppocampal formation: hippocampus, Dentate gyrus 3. Mamillary body: Hypothalamus 4. Thalamus: Anterior nucleus, Medial nucleus 5. Prefrontal cortex 6. Amygdaloid nucleus 7. Septal area 8. Habenular nucleus 7 3/30/2023
  • 8. COMPONENTS: Nuclei 1. Limbic lobes: 3 parts: Cingulate gyrus, Para-hippocampal gyrus, Uncus 2. Hyppocampal formation: hippocampus, Dentate gyrus 3. Mamillary body: Hypothalamus 4. Thalamus: Anterior nucleus, Medial nucleus 5. Prefrontal cortex 6. Amygdaloid nucleus 7. Septal area 8. Habenular nucleus 8 3/30/2023
  • 9. COMPONENTS: Nuclei 1. Limbic lobes: 3 parts: Cingulate gyrus, Para- hippocampal gyrus, Uncus 2. Hyppocampal formation: hippocampus, Dentate gyrus 3. Mamillary body: Hypothalamus 4. Thalamus: Anterior nucleus, Medial nucleus 5. Prefrontal cortex 6. Amygdaloid nucleus 7. Septal area 8. Habenular nucleus 9 3/30/2023
  • 10. COMPONENTS: Fiber bundles Connection between Nucleis Fiber bundle Limbic lobe Cingulum Hippocampus/Mamillary body Fornix Mamillary body/Anterior thalamic nucleus Mamillothalamic tract Medial thalamic nucleus/Prefrontal cortex Antero thalamic radiation Amygdaloid nucleus/septal area Stria terminalis Septal area/habernular nucleus Stria medullaris thalami 10 3/30/2023
  • 12. LIMBIC SYSTEM  components structures: limbic cortex(lobes), amygdala, Hippocampus and septal area. The structures form connections between the limbic system and the hypothalamus, thalamus and cerebral cortex The hippocampus ( in memory and learning), the limbic system( in the control of the emotional responses). 12 3/30/2023
  • 13. LIMBIC SYSTEM Cortical structures: Limbic lobe, Hippocampal formation, Septal areas(fornix connecting the hippocampus with mammillary bodies and septal nuclei and prefrontal area(olfactory cortex) 13 3/30/2023
  • 14. LIMBIC SYSTEM Limbic lobe: C-shaped ring of Grey matter on the medial side of each cerebral hemisphere, surrounding the corpus callosum. It includes: subcollosal area, cingulate gyrus, isthmus, parahippocampal, uncus 14 3/30/2023
  • 15. LIMBIC SYSTEM Hippocampus: it is a limbic system structure that involved in FOS( formation organization and storage of memories), important in forming new memories and connecting, emotions and senses such as smell and sound , to memories paired structures in each cerebral hemisphere. It is as a memory indexer by sending memories to the appropriate part of the cerebral hemisphere for long-term storage and retrieving them when necessary 15 3/30/2023
  • 16. LIMBIC SYSTEM Hippocampus: Site: scrolled ( infolding) structure in the inferomedial part of the temporal lobe Fonction: memory(file new memories as they occur) The hippocampus connection are necessary for consolidation of new short term memoies Its principal efferent pathway is called the fornix(=it is C-shaped group of fibers connecting the hippocampus with mammillary body, then to the anterior nuclei of thalamus 16 3/30/2023
  • 17. LIMBIC SYSTEM Hippocampus(fornix): Fornix is consist of 2 fimbria, 2 crus, 1 body and 2 column.  the fornix is an important component of PAPEZ CIRCUIT(based on connecting connecting the hypothalamus with limbic lobe to control emotion 17 3/30/2023
  • 18. LIMBIC SYSTEM amygdale: Site: almost shaped mass of nuclei that lies near( deep within) the temporal pole, close to the tail of the caudate nucleus. Function, the amygdale is involved in emotion, fear, anger, aggression, hormonal secretion. Connection of amygdale: Inputs(association areas of visual, auditory and somatosensory cortices), Outputs(hypothalamus, autonomic nuclei in the brain stem Lesion of the amygdale : lack of emotional responses and docility 18 3/30/2023
  • 19. Functions of limbic system It control a variety of functions including:  Emotions,  Emotional responses  Behavior & Mood (happy, cry, laugh, sad, afraid, aggression, depression)  Motivation.  Memory.  Visceral & Motor responses involved in (sex, pleasure, hunger, and reproduction).  Olfaction. 19 3/30/2023
  • 20. Lesions associated with limbic lobe disorders  Korsakoff’s psychosis (Retrograde = loss of new memories at the time of lesion with retained old memories & anterograde amnesia= inability to gain new memories)  Temporal lobe epilepsy  The hippocampus is a common focus site in epilepsy, and can be damaged through chronic seizures.  It is sometimes damaged in diseases such as herpes encephalitis,  Alzheimer’s disease: The hippocampus is one of the first brain areas to show damage in Alzheimer's disease  Schizophrenia.  Lesion in the Amygdaloidal nucleus causes loss of aggressive behavior, fear and anger  Bilateral lesion of the amygdaloidal and hippocampus causes increased appetite and abnormal hypersexual behavior 20 3/30/2023
  • 22. Lesions associate with reticular formation Lesions to major pathways of the reticular activating system can thus impair consciousness and severe damage can cause:  coma or a persistent vegetative state,  Parkinson’s disease  Schizophrenia  Secondary brain injury  Diffuse axona injury(DAI) 22 3/30/2023
  • 23. REFERENCES 1. SNELL RS. Clinical Neuro-anatomy. 7th ed. 2. BRS Neuro-anatomy 3. Textbook of Anatomy : Head, Neck and Brain. (Vishram Sing)(z-lib.org) 1. Netter’s Atlas of Human Anatomy 6th edition 2. Teach me anatomy. 23 3/30/2023

Editor's Notes