This document discusses the development of an alternative to traditional adhesive bandages that uses micro-needle anchors instead of adhesive to hold wounds closed. It aims to avoid skin irritation caused by adhesives while providing better tension retention over time. The prototype uses a polystyrene patch with pencil-shaped micro-needle anchors oriented in squares that are hot pressed into the material. Further developments aim to reduce thickness, explore more polymers, increase coverage area, and add wound healing properties. Potential applications include both external and internal use, on various tissues. The goal is to create a customizable bandage alternative that can better aid wound healing.
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Physical Adhesive Patch for Wound Protection
2. Introduction
• Market for wound management product is increasing
• Develop alternative of chemical adhesive bandage
– “The quickest and easiest medical aid in any circumstance”
• Physical adhesion patch
– uses swelling nature of the micro-needles to physically
hold an open wound or a cut on the skin and internal
organs
“Bring surgical treatment to home”
Page 2
4. Business Market for bandage
Page 4
• Market age: 94 years
• Wound management
product increasing
• Wound closures will remain
the largest selling group of
wound management
products
Johnson & Johnson. (2014, March. 20). Annual Report 2013, [Online]. Available:
http://www.jnj.com/
6. Limitations of chemical adhesion
• Skin irritant
– Allergies by glues used for adhesives (contact dermatitis)
– Damp skin underneath the patch
– Sticky residues
• Durability issue
– Does not retain much tension on the skin required for a scar-free
healing
– Contact with water compromises the performance of adhesives
Page 6
7. What we want to achieve
• Primary goal
– create functional prototype
• Adhesion, tension retention and durability
• Secondary goal
– Extend prototype to different application
• Internal and External
• Under water
• Tertiary goal
– Commercialization
Page 7
9. Theoretical design*
Page 9 S. Y. Yang et al., “A bio-inspired swellable microneedle adhesive for mechanical
interlocking with tissue”, Nature COMMUNICATIONS, Vol. 4, No. 1702, 2013
13. Materials (structural layer)
Page 13
Poly-
etheretherketone
Polyetherimide Polycarbonate Polystyrene
Young's modulus
(GPa)
3.6 2.9–3.04 2.0–2.4 3.0–3.6
Tensile strength
(MPa)
90–100 92–101 55–75 46–60
Glass transition
temperature
143 °C 217 °C 147 °C 100 °C
O2 permeation
(x10-13.cm3.cm.cm-
2.s-1.Pa-1)
0.06-0.1 0.01 1.05 2
14. Materials (swellable layer)
Page 14
Poly acrylic acid Polyacrylamide Polyvinyl alcohol
Glass transition
temperature
70 °C 165 °C 85 °C
Price per 5g $40-49 $88.90 $9.06*
Costs from Sigmal Aldrich
*Value derived from $45.30 per 25g
15. Synthesis Methods
Page 15
Micro-milling 3D printing Lithography
Pros -accurate feature size
-Low mold cost (Al)
-Gas escape holes
-strong and effective mold
-precise shape(design)
-cheap
-short process time
-wide range of feature size
-smooth and sharp features
Cons -high possibility of fracturing
the drill tip
-limitation of feature shape( no
cone shape)
-rough features on the sides of
the molded material
-run time too long
-feature size range is too large
-Material used for 3D printing not
suitable for our prototype
material
-micro-scale hard to achieve
-expensive
-limitation in feature depth
(700um depth not achievable)
- feature ratio not suitable for our
design
18. Further developments
• Reduce thickness of the patch
• Explore more polymers using same
manufacturing technique
• Scale up coverage area
• Increase surface area
– Shorter + smaller diameter anchors, more dense
Page 18
21. Applications – Internal
• Soft tissue wounds from invasive surgery
• Important Properties
– Flexibility
– Retain tension
– Transparency
– Breathability
• Next Steps
– Thinner
– Polymer choice
– Anchor design
Page 21
22. Acknowledgement
• Consultant: Professor Bo Cui Template
• Manufacturer : Professor Richard Culham
Jason Benninger
• Anti-adhesive Coating: Celal Con
• Administrative: Jennifer Coggan
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#5: We’re the fastest-growing top 10 Pharmaceutical Company in the United
States, Europe and Japan and recorded 15 consecutive quarters of operational sales growth in this segment.
S. Y. Yang et al., “A bio-inspired swellable microneedle adhesive for mechanical interlocking with tissue”, Nature COMMUNICATIONS, Vol. 4, No. 1702, 2013