This innovative study relates patient empowerment to strategies for education and e-health information to support self-care to patients with knee surgery in a Danish university hospital outpatient clinic. Interdisciplinary teamwork and Information and Communication Technology are integral parts of the programme for self-care. Empowerment core values and themes in the programme were analysed in a qualitative study including focus-group interviews from patients and the interdisciplinary team. Findings qualified following workshops, where the professionals participated in web design of a prototype website. The website was evaluated for the implemented effects and factors for empowering interactions between health professionals and patients.