skip to main content
10.1145/3071178.3071322acmconferencesArticle/Chapter ViewAbstractPublication PagesgeccoConference Proceedingsconference-collections
research-article

A comparison of genetic regulatory network dynamics and encoding

Published: 01 July 2017 Publication History

Abstract

Genetic Regulatory Networks (GRNs) implementations have a high degree of variability in their details. Parameters, encoding methods, and dynamics formulas all differ in the literature, and some GRN implementations have a high degree of model complexity. In this paper, we present a comparative study of different implementations of a GRN and introduce new variants for comparison. We use a modified Genetic Algorithm (GA) to evaluate GRN performance on a number of common benchmark tasks, with a focus on real-time control problems. We propose an encoding scheme and set of dynamics equations that simplifies implementation and evaluate the evolutionary fitness of this proposed method. Lastly, we use the comparative modifications study to demonstrate overall enhancements for GRN models.

Supplementary Material

ZIP File (p91-disset.zip)
Supplemental material.

References

[1]
Wolfgang Banzhaf. 2003. Artificial regulatory networks and genetic programming. In Genetic programming theory and practice. Springer, 43--61.
[2]
Arturo Chavoya and Yves Duthen. 2008. A cell pattern generation model based on an extended artificial regulatory network. BioSystems 94, 1--2 (2008), 95--101.
[3]
Sylvain Cussat-Blanc, Nicolas Bredeche, Hervé Luga, Yves Duthen, and Marc Schoenauer. 2011. Artificial Gene Regulatory Network and Spatial Computation: A Case Study. European Conference on Artificial Life (2011).
[4]
Sylvain Cussat-Blanc and Kyle Harrington. 2015. Genetically-regulated Neuro-modulation Facilitates Multi-Task Reinforcement Learning. In Proceedings of the 2015 on Genetic and Evolutionary Computation Conference - GECCO '15. ACM Press, New York, New York, USA, 551--558.
[5]
Sylvain Cussat-Blanc, Kyle Harrington, and Jordan Pollack. 2015. Gene Regulatory Network Evolution Through Augmenting Topologies. IEEE Transactions on Evolutionary Computation 19, 6 (dec 2015), 823--837.
[6]
S Cussat-Blanc, H Luga, and Yves Duthen. 2008. From single cell to simple creature morphology and metabolism. Artificial Life XI (2008), 134--141. http://www.cs.bham.ac.uk/{{~}wb
[7]
P. Dwight Kuo, Wolfgang Banzhaf, and André Leier. 2006. Network topology and the evolution of dynamics in an artificial genetic regulatory network model created by whole genome duplication and divergence. BioSystems 85, 3 (2006), 177--200.
[8]
Michał Joachimczak and Borys Wrobel. 2010. Evolving Gene Regulatory Networks for Real Time Control of Foraging Behaviours. Artificial Life XII. Proceedings of the 12th International Conference on the Synthesis and Simulation of Living Systems (2010), 348--355.
[9]
M.a Joachimczak and B.a b Wróbel. 2010. Processing signals with evolving artificial gene regulatory networks. Artificial Life XII: Proceedings of the 12th International Conference on the Synthesis and Simulation of Living Systems, ALIFE 2010 (2010), 203--210. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874698466
[10]
Johannes Knabe, Chrystpoher Nehaniv, Maria Schilstra, and Tom Quick. 2006. Evolving Biological Clocks using Genetic Regulatory Networks. Artificial Life X: Proceedings of the Tenth International Conference on the Simulation and Synthesis of Living Systems Alife 10 (2006), 15--21. c:/Daniel/Work/Library/workLibrary.Data/PDF/2088839662/Knabe2006.pdf
[11]
Miguel Nicolau, Marc Schoenauer, and Wolfgang Banzhaf. 2010. Evolving genes to balance a pole. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 6021 LNCS (2010), 196--207. arXiv:1005.2815
[12]
Kenneth O Stanley, David B D'Ambrosio, and Jason Gauci. 2009. A hypercube-based encoding for evolving large-scale neural networks. Artificial life 15, 2 (2009), 185--212.
[13]
Kenneth O Stanley and Risto Miikkulainen. 2002. Evolving neural networks through augmenting topologies. Evolutionary computation 10, 2 (2002), 99--127.
[14]
M.A. Trefzer, T. Kuyucu, Julian F Miller, and A.M. Tyrrell. 2013. On the Advantages of Variable Length GRNs for the Evolution of Multicellular Developmental Systems. IEEE Transactions on Evolutionary Computation 17, 1 (2013), 100--121.
[15]
Dennis Wilson, Emmanuel Awa, Sylvain Cussat-Blanc, Kalyan Veeramachaneni, and Una-May O'Reilly. 2013. On learning to generate wind farm layouts. Fifteenth annual conference on Genetic and evolutionary computation conference (2013), 767--774.
[16]
Borys Wróbel and Ahmed Abdelmotaleb. 2012. Evolving Spiking Neural Networks in the GReaNs (Gene Regulatory evolving artificial Networks) Plaftorm. EvoNet2012: Evolving Networks, from Systems/Synthetic Biology to Computational Neuroscience Workshop at Artificial Life XIII (2012), 19--22.
[17]
Borys Wrobel, Ahmed Abdelmotaleb, and Michał Joachimczak. 2014. Evolving networks processing signals with a mixed paradigm, inspired by gene regulatory networks and spiking neurons. Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST 134 (2014), 135--149.

Cited By

View all

Index Terms

  1. A comparison of genetic regulatory network dynamics and encoding

      Recommendations

      Comments

      Information & Contributors

      Information

      Published In

      cover image ACM Conferences
      GECCO '17: Proceedings of the Genetic and Evolutionary Computation Conference
      July 2017
      1427 pages
      ISBN:9781450349208
      DOI:10.1145/3071178
      Permission to make digital or hard copies of all or part of this work for personal or classroom use is granted without fee provided that copies are not made or distributed for profit or commercial advantage and that copies bear this notice and the full citation on the first page. Copyrights for components of this work owned by others than the author(s) must be honored. Abstracting with credit is permitted. To copy otherwise, or republish, to post on servers or to redistribute to lists, requires prior specific permission and/or a fee. Request permissions from [email protected].

      Sponsors

      Publisher

      Association for Computing Machinery

      New York, NY, United States

      Publication History

      Published: 01 July 2017

      Permissions

      Request permissions for this article.

      Check for updates

      Author Tags

      1. fitness evaluations
      2. genetic algorithms
      3. representations

      Qualifiers

      • Research-article

      Conference

      GECCO '17
      Sponsor:

      Acceptance Rates

      GECCO '17 Paper Acceptance Rate 178 of 462 submissions, 39%;
      Overall Acceptance Rate 1,669 of 4,410 submissions, 38%

      Contributors

      Other Metrics

      Bibliometrics & Citations

      Bibliometrics

      Article Metrics

      • Downloads (Last 12 months)1
      • Downloads (Last 6 weeks)0
      Reflects downloads up to 25 Dec 2024

      Other Metrics

      Citations

      Cited By

      View all

      View Options

      Login options

      View options

      PDF

      View or Download as a PDF file.

      PDF

      eReader

      View online with eReader.

      eReader

      Media

      Figures

      Other

      Tables

      Share

      Share

      Share this Publication link

      Share on social media