This paper proposes a head-local-exposure system using a figure-8 loop antenna for 2-GHz band operation. This system allows us to observe biological effects through microcirculation of the rat brain simultaneously with exposure through a cranial window, i.e., the window made by transparent glass and implanted on the surface of the rat brain. The specific absorption rate (SAR) in a rat exposed to microwaves due to the new exposure system is estimated numerically and experimentally. The ratio of averaged SAR between the target area, which is the brain's surface just under the cranial window, and the whole body is about 59 for the 8-week rat model and 13 for the 2-week rat model. This antenna achieves local exposure for the rat brain for 2-GHz band operation.