Exercise Pathophysiology in Interstitial Lung Disease

Yannick Molgat-Seon; Michele R Schaeffer; Christopher J Ryerson; Jordan A Guenette

doi:10.1016/j.ccm.2019.02.011

Exercise Pathophysiology in Interstitial Lung Disease

Clin Chest Med. 2019 Jun;40(2):405-420. doi: 10.1016/j.ccm.2019.02.011.

Authors

Yannick Molgat-Seon¹, Michele R Schaeffer¹, Christopher J Ryerson², Jordan A Guenette³

Affiliations

¹ Centre for Heart Lung Innovation, St. Paul's Hospital, 166-1081 Burrard Street, Vancouver, British Columbia V6T 1Y6, Canada; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 212 Friedman Building, 2177 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada.
² Centre for Heart Lung Innovation, St. Paul's Hospital, 166-1081 Burrard Street, Vancouver, British Columbia V6T 1Y6, Canada; Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Gordon and Leslie Diamond Health Care Centre, 7th Floor, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada.
³ Centre for Heart Lung Innovation, St. Paul's Hospital, 166-1081 Burrard Street, Vancouver, British Columbia V6T 1Y6, Canada; Department of Physical Therapy, Faculty of Medicine, University of British Columbia, 212 Friedman Building, 2177 Wesbrook Mall, Vancouver, British Columbia V6T 1Z3, Canada; Division of Respiratory Medicine, Faculty of Medicine, University of British Columbia, Gordon and Leslie Diamond Health Care Centre, 7th Floor, 2775 Laurel Street, Vancouver, British Columbia V5Z 1M9, Canada. Electronic address: [email protected].

PMID: 31078218
DOI: 10.1016/j.ccm.2019.02.011

Abstract

Interstitial lung disease (ILD) is a heterogeneous group of disorders that primarily affect the lung parenchyma. Patients with ILD have reduced lung volumes, impaired pulmonary gas exchange, and decreased cardiovascular function. These pathologic features of ILD become exacerbated during physical exertion, leading to exercise intolerance and abnormally high levels of exertional dyspnea. In this review, the authors summarize the primary pathophysiologic features of patients with ILD and their effect on the integrative response to exercise.

Keywords: Dyspnea; Exercise intolerance; Hypoxemia; Idiopathic pulmonary fibrosis; Pulmonary gas exchange; Restrictive ventilatory impairment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Dyspnea / physiopathology*
Exercise / physiology*
Humans
Lung Diseases, Interstitial / physiopathology*
Lung Diseases, Interstitial / therapy*

Grants and funding

CIHR/Canada