Regulation of ABC transporters at the blood-brain barrier

Clin Pharmacol Ther. 2015 Apr;97(4):395-403. doi: 10.1002/cpt.64. Epub 2015 Jan 20.

Abstract

ATP binding cassette (ABC) transporters at the blood-brain barrier function as ATP-driven xenobiotic efflux pumps and limit delivery of small molecule drugs to the brain. Here I review recent progress in understanding the regulation of the expression and transport activity of these transporters and comment on how this new information might aid in improving drug delivery to the brain.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / biosynthesis
  • ATP-Binding Cassette Transporters / genetics
  • ATP-Binding Cassette Transporters / metabolism*
  • Animals
  • Blood-Brain Barrier / metabolism*
  • Gene Expression Regulation
  • Humans

Substances

  • ATP-Binding Cassette Transporters