Successful pregnancy complicated by persistent pneumothorax in a patient with lymphangioleiomyomatosis (LAM) on sirolimus

M Faehling; S Frohnmayer; M Leschke; B Trinajstic-Schulz; J Weber; F Liewald

Successful pregnancy complicated by persistent pneumothorax in a patient with lymphangioleiomyomatosis (LAM) on sirolimus

Sarcoidosis Vasc Diffuse Lung Dis. 2011 Oct;28(2):153-5.

Authors

M Faehling¹, S Frohnmayer, M Leschke, B Trinajstic-Schulz, J Weber, F Liewald

Affiliation

¹ Klinik für Kardiologie und Pneumologie, Klinikum Esslingen, Esslingen; 2Lungenfacharztpraxis, Esslingen. [email protected]

PMID: 22117507

Abstract

We report a successful pregnancy in a patient with longstanding LAM on treatment with sirolimus. During temporary discontinuation fo sirolimus in early pregnancy, lung function declined but recovered after resumption of sirolimus. Pregnancy was complicated by a persistent pneumothorax which was treated surgically postnatally. The child has had a normal development despite exposure to low dose sirolimus intermittently during early embryonal and mid-fetal life.

Publication types

Case Reports

MeSH terms

Adult
Antibiotics, Antineoplastic / administration & dosage
Drug Administration Schedule
Female
Humans
Live Birth
Lung / drug effects
Lung / physiopathology
Lymphangioleiomyomatosis / complications*
Lymphangioleiomyomatosis / drug therapy
Lymphangioleiomyomatosis / physiopathology
Pneumothorax / diagnostic imaging
Pneumothorax / etiology*
Pneumothorax / physiopathology
Pneumothorax / surgery
Pregnancy
Pregnancy Complications, Neoplastic*
Radiography
Sirolimus / administration & dosage

Substances

Antibiotics, Antineoplastic
Sirolimus