NCI Center for Cancer Research

🎉 Last week, we celebrated the incredible career of Steven A. Rosenberg, M.D., Ph.D., Chief of the Surgery Branch. Hundreds of attendees both in-person and online came together to honor his pioneering in the development of effective immunotherapies for patients with advanced cancer. Former and current colleagues, trainees and patients were able to thank Dr. Rosenberg for his impact on the field and discuss the optimism they have for the future of cancer research because of his work.    Thank you to the Center for Excellence in Immunology for sponsoring, the organizers and to everyone who participated in this incredible symposium. 👏 Share your favorite photo if you attended or a memory you have with Dr. Rosenberg in the comments! National Cancer Institute (NCI), NIH Clinical Center (CC), The National Institutes of Health

Researchers in Germany have named a new species of bacteria after Susan Gottesman, Ph.D., Chief of the Laboratory of Molecular Biology: Streptomyces gottesmaniae (DSM 3412), in honor of her major contributions in the fields of microbiology, biochemistry and molecular biology.   The group recently published the isolation and characterization of 28 new bacterial species in the Gram-positive phylum of Actinomycetota, which includes the genus Streptomyces that produces many natural antibiotics, as well as the cancer chemotherapeutic doxorubicin. They decided to name all the species they isolated after prominent women in science.   Gottesman states that the paper showcases how bacterial diversity is continually expanding and being mined to find new uses, frequently in unexpected and potentially beneficial ways. “I’m honored to be among the list of women microbiologists they chose to include here. I hope my namesake bacteria has a useful future,” she says. ➡ https://go.nih.gov/qwe8Ov2 ⭐ The figure shows antimicrobial activities of the studied strains against Gram-positive and Gram-negative bacteria and yeast. National Cancer Institute (NCI), The National Institutes of Health, National Institutes of Health (NIH): Intramural Research Program (IRP)

🗞 IN THE NEWS: Johnathan M. Hernandez, M.D., a physician in our Surgical Oncology Program, was featured in this BBC News article about Madi Foster, a patient who traveled from the UK to receive treatment for adrenocortical carcinoma at the NIH Clinical Center. ➡ https://go.nih.gov/HqVo4n6 National Cancer Institute (NCI), The National Institutes of Health, NIH Clinical Center (CC)

💡 Check out this research by Stavroula Mili, Ph.D., a Senior Investigator in our Laboratory of Cellular and Molecular Biology!

We're excited to be at the SACNAS #2024NDiSTEM conference in Phoenix, AZ! 🌵🎉 Visit us at booth 606, where CCR’s Office of Equity and Inclusion and NCI’s Center for Cancer Training are sharing all the ways you can Train at NCI. Whether you’re a student, postdoc, or early-career scientist, stop by to explore the training opportunities available! ➡ https://lnkd.in/ezPDBXwE National Cancer Institute (NCI), Train at NCI

💡 NEW FINDINGS: A team of researchers led by Eytan Ruppin, M.D., Ph.D., developed a machine-learning model called the Immunotherapy Resistance cell-cell Interaction Scanner (IRIS) to identify interactions in the tumor microenvironment that may play a role in immune checkpoint blockade (ICB) resistance.    The interactions IRIS found were related to stimulatory chemokine recruitment of CD8+ T cells to the tumor, which were downregulated in melanoma with ICB resistance. IRIS’s findings emphasize the importance of investigating how to enhance this signaling to maintain CD8+ T cell infiltration and improve anti-tumor responses.   ➡ Read more: https://lnkd.in/eTmhs7ec   Image Description: Hypothesized evolution of immune microenvironment in melanoma during ICB treatment. National Cancer Institute (NCI), The National Institutes of Health, National Institutes of Health (NIH): Intramural Research Program (IRP), Eytan Ruppin

🗞 IN THE NEWS: Sen. Jack Reed (D-RI) visited NIH in September and stopped by the labs of Christine M. Heske, M.D., and Brigitte C. Widemann, M.D., from our Pediatric Oncology Branch. Read more in this article in the NIH Record. ➡ https://go.nih.gov/nRqTJKW ⭐ In the first photo, Dr. Heske shows Reed a well plate containing rows of treated and untreated cells for comparison. ⭐ In the second photo, Monica Bertagnolli, M.D., NIH Director, chats with Reed and Dr. Widemann while walking through the Clinical Center's Pediatric Oncology wing. National Cancer Institute (NCI), The National Institutes of Health, NIH Clinical Center (CC)

More renowned speakers are on the agenda for the #NCIConnect and #MyPART webinar, titled: AYA and Primary CNS Tumors: Unmet Needs and Opportunities for Collaboration. These speakers are addressing Care and Clinical Trial Access for adolescents and young adults (AYA) with primary central nervous system (CNS) tumors. Don't miss your opportunity to hear from Drs. Mark Gilbert, Nicole Drezner, Brigitte Widemann, and Marta Penas-Prado. REGISTER: https://go.nih.gov/nQcX4We. 📅 Wednesday, October 30, at 11 a.m. ET. Co-hosted by National Cancer Institute (NCI) and NCI Center for Cancer Research Cancer Moonshot programs, NCI-CONNECT and MyPART.

💡 NEW FINDINGS: Osteosarcoma is a rare, aggressive bone cancer that is most often found in children and young adults, but that also happens to be common in pet dogs. In a new study, researchers from CCR, including Amy LeBlanc, D.V.M., Baris Turkbey, M.D., Peter Choyke, M.D., and Stephanie Harmon, Ph.D., analyzed tumor data from 245 pet dogs with naturally occurring osteosarcoma and identified three distinct subtypes of tumor microenvironments, which could help predict survival outcomes.    The researchers also found these same three subtypes in human osteosarcoma, suggesting that these studies in dogs can be used to gain a better understanding of how the disease progresses in humans 🐶   ➡ Read more: https://lnkd.in/eu3hUuZQ   Image Description: Kaplan-Meier survival plots showing overall survival (A) and disease-free intervals (B) for 186 canines. The three tumor microenvironment subtypes strongly stratify both overall survival and disease-free intervals. National Cancer Institute (NCI), The National Institutes of Health, NIH Clinical Center (CC), National Institutes of Health (NIH): Intramural Research Program (IRP)

Interested in leveraging CRISPR-based technology to study genetic determinants of oxidative stress? Join us at National Institutes of Health (NIH): Intramural Research Program (IRP). We have a Postdoc position in my Group at NCI Center for Cancer Research. https://lnkd.in/eu4-sEFT