Targeted drug treatment leads tumor cells to imitate viral infection
Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.
![A graphic showing a virus trapped behind a lock wrapped in spider webs, beside a pill with a key inside A graphic showing a virus trapped behind a lock wrapped in spider webs, beside a pill with a key inside](/https/www.broadinstitute.org/files/styles/multiple_ct_header_phone/public/longstory/IDH1-NewsStory_v03.png?h=ae0fde30&itok=mgbjXqnl)
Credit: Ricardo Job-Reese, Broad Communications
A graphic showing a virus trapped behind a lock wrapped in spider webs, beside a pill with a key inside
funding
Support for this study was provided by the National Cancer Institute, the TargetCancer Foundation, the Massachusetts Life Science Council, the Cholangiocarcinoma Foundation, and other sources.
paper cited
Wu M, Kondo H, et al. Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity. Science. Online July 11, 2024. DOI: 10.1126/science.adl6173.