Victor Tkachev’s Post

Exciting news! 🎉 I’m honored to receive a research grant from the Leukemia Research Foundation to explore the role of tissue-resident T lymphocytes in acute graft-versus-host disease (aGVHD). My project, titled "Separating Graft-versus-Leukemia Effect from Graft-versus-Host Disease after Transplantation by Targeting Tissue-Residency Pathways in Donor T Lymphocytes," aims to uncover new strategies to enhance transplant outcomes. Grateful for this opportunity to contribute to advancements in leukemia treatment and patient care! #LeukemiaResearch #Transplantation #aGVHD #Immunology https://lnkd.in/eGTHX8Z5

My lab is hiring! A postdoctoral position is available in the Dr. Victor Tkachev’s laboratory at Massachusetts General Hospital - Harvard Medical School to study the immunobiology of Graft-versus-Host Disease (GVHD) - the major cause of morbidity and mortality of patients after allogeneic hematopoietic stem cell transplantation (HSCT). Our group uses animal models, including unique HSCT model in non-human primates, traditional and systems immunology approaches to interrogate the mechanism driving pathogenic alloimmunity during GVHD.   We discovered that GVHD-induced tissue immunopathology in barrier organs is driven by tissue-infiltrating T cells that rapidly acquire pathogenic tissue-resident characteristics (Tkachev V et al, (2021) Sci. Transl. Med). This seminal discovery nominates potentially targetable pathways orchestrating tissue-invasiveness and tissue-residency programs in T cells during GVHD and spark our interest to understanding the organ-specific roles of tissue-resident T cells in HSCT settings. We are currently investigating whether specific targeting these cells provides the opportunity to separate GVHD, mainly affecting barrier organs, from beneficial graft-versus-leukemia (GVL) effect, primarily mediated in the lymphoid tissues.   The Dr. Victor Tkachev’s laboratory is a recently established research unit within the MGH Center for Transplantation Sciences, which offers a great opportunity to get expertise in basic and translational immunology and to work in a highly productive, as well as highly collaborative and supportive multi-disciplinary environment. The indicated studies will be conducted as a part of existing collaboration involving Dr. Tkachev’s laboratory, CTSI laboratory at Boston Children’s Hospital, led by Dr. Leslie Kean, and other investigators within Harvard Medical School and beyond.   The Research Fellow will work to independently carry out a scientific project with minimal supervision from the PI of the laboratory. This includes design and execution of highly specialized experiments, collection of and accurate recording of procedures and results, and summarization of the findings for publication. Candidates must be highly motivated, well organized, technically proficient, critically minded, and able to work independently but collaboratively with others. Candidates must possess a recent PhD, MD, or MD/PhD with background in cellular or molecular immunology. Extra consideration will be given to those with relevant experience with T cell immunology, advanced flow cytometry, and systems biology.   To apply, please send the following materials to Dr. Victor Tkachev ([email protected]): 1.        Cover letter describing prior experience, career goals, and your motivation to apply for this position. 2.        CV + publication records. 3.        Names and contact information for 3 references. Ukrainian candidates are particularly encouraged to apply. #hiring #mgh #immunology #helpukraine

My first job posting is up! I am looking for a research assistant to join my new lab at MGH. If interested, please, apply online here: https://lnkd.in/e5kUmtwT #jobposting #hiring #mgh

I am thrilled to share the exiting news that I am starting a new position as Assistant Professor at the Massachusetts General Hospital/Harvard Medical School. After many years of being trained by the giants in this field – professors James Ferrara and Leslie Kean – I am now set to become a principal investigator at the top research institution in the country. I am incredibly thankful to my mentors, colleagues, my family and all my supporters. My new lab will be part of the Center for Transplantation Sciences at MGH and will focus on restoring immune homeostasis in transplant patients. We will use traditional immunologic techniques and systems biology approaches to better understand the determinants of physiologic immune reconstitution and to uncover the mechanisms of alloimmune response after hematopoietic stem cell transplantation and solid organ transplantation. I hope my new lab will start hiring very soon. There is so much work ahead. It is going to be fun and amazing journey!