VIB’s Post

Recently, there have been emerging suggestions of a possible role for the gut microbiota in amyotrophic lateral sclerosis (ALS). This month, in an International Journal of Molecular Sciences article, investigators discuss the possible role of gut-derived neurotoxins/excitotoxins in this disease. Read the review: https://lnkd.in/drKFZCZD #als #gutbrainconnection #gutmicrobiome

Our latest research letter, "Unraveling the Role of Complement in Focal Segmental Glomerulosclerosis Pathogenesis: Insights and Challenges."

it is always nice to see a bright PhD student to excell in the field of LNP inflammation targeting. The targeting of LNPs has such a great power.

I am glad to share with you our latter paper about the effect of Corinthian currants on the antioxidant status in serum and brain of a mouse model of Alzheimer’s Disease. https://lnkd.in/du5F7esK

What is all the hype with photobiomodulation? Applications of the clinical treatment with light include treatment of Stroke, Alzheimer's, pain management, depression, and boosting athletic performance (at the gym and in the bedroom). Red light (600-810 nm) is absorbed by mitochondria's cytochrome c oxidase enzyme, which then displaces nitric oxide. This activation boosts ATP production, increases calcium ions and reactive oxygen species levels. Near-infrared light (810-1064 nm) activates specific ion channels, enhancing calcium levels, reactive oxygen species, and cyclic AMP interactions. These processes collectively promote cell differentiation, proliferation, and migration. Michael Hamblin at MGH Wellman is one of the pioneers in the file and has published over 200 articles in the field. 1. The Hype Around Photobiomodulation https://lnkd.in/es4pfTSU. 2. Photobiomodulation—Underlying Mechanism and Clinical Applications https://lnkd.in/e627Grvi

🔹Examining modulators of the optic nerve head and their role in primary open-angle glaucoma (POAG) 🔹 For November, our intricate Image of the Month was produced by Dillinger et al from the University of Regensburg. Through investigation of the optic nerve head and the molecular factors involved in ECM changes, they found a self-amplifying signalling process that may ultimately contribute to POAG pathogenesis, a devastating disease which can cause blindness. 📷 Pictured is the use of a Cy3-AffiniPure Goat Anti-Rabbit IgG (H+L) (min X Hu,Ms,Rat Sr Prot) from Jackson ImmunoResearch. Image collected and cropped by CiteAb under a CC-BY license from: Dillinger et al. (2022) Front Cell Dev Biol. https://lnkd.in/ed9uYq3j

✨CSC11 SPEAKER SPOTLIGHT - Dr. Dayan Goodenowe ✨ Dr. Goodenowe’s research into the biochemical mechanisms of disease started in 1990. His curiosity about the biochemistry of life is as insatiable today as it was 30 years ago. In those 30 years, Dr. Goodenowe invented and developed advanced diagnostic and bioinformatic technologies, designed and manufactured novel and natural biochemical precursors, and identified biochemical prodromes of numerous diseases including Alzheimer’s disease and dementia, Parkinson’s disease, multiple sclerosis, and others. And he is just getting warmed up. Dr. Goodenowe is now going beyond disease and the detection of biochemical dysfunctions to diagnose and the correction of biochemical dysfunctions to treat disease. Dr. Goodenowe’s new focus is to defeat the entropy of aging by creating strategic biochemical and biofunctional reserve capacity in advance of known disease risks such that the human body can maintain the physical and biological functions of life indefinitely and without disease.

There is still so much we do not fully understand about GFAP and its proteoforms! In this study we attempted to find out more about the dynamics of GFAP under different conditions combining HDX-MS and bioinformatics approaches. Many thanks to all the co-authors, LGC, and MIRIADE E.U. for facilitating this research project: https://lnkd.in/dxuaAzmA

Tomorrow - Dr. Chad Deisenroth, PhD, from the US EPA, introduces an advanced human in vitro 3D thyroid microtissue model designed to evaluate thyroid hormone disruption, addressing current challenges with existing models. Developed in collaboration with LifeNet Health, this model offers hormonogenic competence and the capacity to connect mechanistic insights with functional outcomes like thyroid hormone synthesis. Save your spot: https://bit.ly/4d4S4HF

Reduced mitochondrial respiratory activity in immune cells might be (at least partially) a non-representative observation as both PBMC from depressed and non-depressed individuals are generally measured in standardized laboratory procedures using 37 °C only. How the mitochondrial respiration profile changes with temperature has not been reported in the context of MDD, but is a tremendously important question for the interpretation of results from both preclinical and clinical research. Higher inflammation-related body temperature might be a compensatory mechanism to reconstitute physiological impairments due to the disorder, and on this poster we provide first empirical evidence for this assumption by comparing oxygen consumption rates at 37 °C vs. 39 °C. Enjoy reading...the paper with the full story is coming next :-)