We are proud to announce that the UPMC Heart Transplant Program was recently recognized by the Scientific Registry of Transplant Recipients (SRTR) as a top transplant program in several distinct outcome categories. Notably, UPMC demonstrated the best performance in the United States in 90-day survival with a functioning graft rate following adult heart transplantation. In addition to achieving excellent outcomes, experts at UPMC are also committed to providing access to transplant for our patients. “It’s extremely rewarding to be able to transplant patients who have no other options,” said David Kaczorowski, MD, surgical director of the UPMC Heart Transplant Program. UPMC was the highest volume heart transplant center in Pennsylvania in 2023. UPMC’s rich legacy and excellent outcomes continue define the program as a pioneer in the field of heart transplant. Learn more about our heart transplant program from Dr. Kaczorowski.
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The creation of a nationwide organ transplant allocation policy has successfully enabled the sickest lung patients to receive transplants sooner. A new research paper, led by Royal Papworth researchers, shows lung transplant waiting times dropped from a median of 427 days to 292 days and the odds of being transplanted within six months increased by 41%. The updated UK Lung Allocation Scheme (UKLAS) was introduced by NHS Blood and Transplant with advice from the Cardiothoracic Advisory Group (Lungs). The group's chair is Dr Jasvir Parmar, Lung Transplant Consultant at Royal Papworth Hospital. The changes to the former scheme included creating new ‘Urgent’ and ‘Super Urgent’ patient categories and replacing the five geographic zones with a nationwide system. Dr Parmar said: “Creating the urgent categories led to a dramatic reduction on the median waiting times to transplant and, moreover, it did not disadvantage non-urgent registrations, with no difference in waiting-list deaths. “The new policy has fulfilled its goals of prioritising the most critically ill and improving the odds of transplantation." https://lnkd.in/eeH8r7g4 #NHS #NHSBT #Transplantation #Transplant #OrganDonation #Excellence
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Professor & Vice Chairman, Department of Cardiothoracic Surgery Montefiore Health System. LinkedIn # 1 2020 Top Voice in Healthcare
A Fairer Heart Transplant Allocation System 2/14/24 On this Valentine’s Day, and this February Heart Month, it is great to see this publication which proposes a newer allocation system for HEART ❤️ transplantation alike those already employed for liver, lung and kidney transplantation - based on OBJECTIVE criteria and not the subjective assessments that are highly susceptible to manipulation. The proposed mechanism performs better (c-statistic) than the current 6-tier system and the French allocation system in predicting death without transplant. It is just a matter of time before the ❤️ transplant community develops and deploys this more rational and equitable allocation system. #hearttransplant #allocation #meld #las #unos
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Professor of Cardiology @ Hannover Medical School, Founder and CSO/CMO @ Cardior Pharmaceuticals | MD, PhD, Heart Disease, RNA enthusiast
Details and #guidelines for the #prevention and #rehabilitation after heart transplantation (#HTx) are not available. Please see here our just published joint #scientific #statement paper with the topics (i) to explain the importance of prevention and rehabilitation after HTx, and (ii) to promote the factors (modifiable/non-modifiable) that should be addressed after HTx to improve patients' physical capacity, quality of life and survival. https://lnkd.in/ekR_CbUw
Prevention and Rehabilitation After Heart Transplantation: A Clinical Consensus Statement of the European Association of Preventive Cardiology, Heart Failure Association of the ESC, and the European Cardio Thoracic Transplant Association, a Section of ESOT - PubMed
pubmed.ncbi.nlm.nih.gov
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The world’s first heart transplant was made possible through the concept of organ donation after circulatory death (DCD). Also referred to in the past as non-heart beating organ donors, these individuals have severe brain injury but do not meet the requirements for being declared brain dead. Accordingly, it is necessary to remove all life support measures and wait for the heart and circulation to stop for a defined period of time before the declaration of death. Following this it is permissible to remove organs for transplantation. The heart can become injured quickly if it is without a blood supply so it was largely believed that the organ would not be able to endure such an insult and still be suitable for transplantation. In 1967, Dr. Christiaan Barnard utilized this technique as there was no legal method to remove organs for transplant before the declaration of death of the organ donor. Legal definitions of brain death were not accepted until many years later. Through looking back into our past it is possible to impact our future. This initial experience led us to question whether the strategy could be a viable proposition for modern day heart transplantation. #hearttransplant #donatelife #organdonation
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📣 Publication alert: Excited to see UZ Leuven’s report on their first series of three successful clinical transplantations of DCD hearts using direct procurement followed by hypothermic oxygenated perfusion (DP-HOPE). 👇Check out post below for more details and link to summary. #HOPE #heart #transplant #extendinghorizons #HOPEforHearts #XHAT
𝐒𝐮𝐜𝐜𝐞𝐬𝐬𝐟𝐮𝐥 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐭𝐫𝐚𝐧𝐬𝐩𝐥𝐚𝐧𝐭𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐞𝐚𝐫𝐭𝐬 𝐝𝐨𝐧𝐚𝐭𝐞𝐝 𝐚𝐟𝐭𝐞𝐫 𝐜𝐢𝐫𝐜𝐮𝐥𝐚𝐭𝐨𝐫𝐲 𝐝𝐞𝐚𝐭𝐡 𝐮𝐬𝐢𝐧𝐠 𝐝𝐢𝐫𝐞𝐜𝐭 𝐩𝐫𝐨𝐜𝐮𝐫𝐞𝐦𝐞𝐧𝐭 𝐟𝐨𝐥𝐥𝐨𝐰𝐞𝐝 𝐛𝐲 𝐡𝐲𝐩𝐨𝐭𝐡𝐞𝐫𝐦𝐢𝐜 𝐨𝐱𝐲𝐠𝐞𝐧𝐚𝐭𝐞𝐝 𝐩𝐞𝐫𝐟𝐮𝐬𝐢𝐨𝐧: 𝐀 𝐫𝐞𝐩𝐨𝐫𝐭 𝐨𝐟 𝐭𝐡𝐞 𝐟𝐢𝐫𝐬𝐭 3 𝐜𝐚𝐬𝐞𝐬. Read the clinical summary of the recently published report from the clinical team at UZ Leuven, Belgium. https://lnkd.in/dCzzCpDb #HOPE #HOPEforHearts #extendinghorizons #milestone #directprocurement #XHAT #heartbox #organdonation #oxygenation #transplant #heart
Successful clinical transplantation of hearts donated after circulatory death using direct procurement followed by hypothermic oxygenated perfusion: A report of the first 3 cases. | XVIVO
https://www.xvivogroup.com
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VP, Perfusion | Perfusionist | Multi-State Operational Leadership | Product Management | Education | P&L Management | Strategic Development | Recruitment & Retention | Perfusion Legal Expert | Change Implementation
Lessons learned from DCD donors in Australia
Heart Transplantation From DCD Donors in Australia: Lessons Learned From the First 74 Cases
Heart Transplantation From DCD Donors in Australia: Lessons ... : Transplantation
journals.lww.com
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Symposium: Liver Transplantation Meets Cancer 2024 25. Januar 2024, 9.00 Uhr bis 26. Januar 2024, 18.00 Uhr https://lnkd.in/eDEKp8cD #medicaleducation #healthcare #medicine
Symposium: Liver Transplantation Meets Cancer 2024 : med-congress
med-congress.info
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Dear Colleagues, A recent publication in the American Journal of Case Reports by authors from Mayo Clinic, Phoenix, AZ, USA, sheds light on the practical implications of paradoxical air embolism (PAE) during liver transplantation. The case study presents a 60-year-old patient with non-alcoholic steatohepatitis cirrhosis who experienced hemodynamic collapse due to PAE, diagnosed intraoperatively using transesophageal echocardiography. The study highlights the importance of considering PAE as a potential cause of hemodynamic instability in liver transplantation, especially when air is detected in specific cardiac chambers. This valuable insight can aid medical professionals in promptly identifying and managing PAE during liver transplantation procedures. The complete report is now available on the American Journal of Case Reports webpage. | https://lnkd.in/d68z3EN5
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Medical Lead / Medical Affairs / Inflammation and Immunology / Oncology / Pharmaceuticals / Market Access / Biotech / Fighting for inclusion and equity in healthcare.
For the first time, a heart transplant has been successfully performed after transport of a donor heart across the Atlantic Ocean, marking a substantial advancement in the realm of organ transplantation. The heart transplant took place at the Pitié-Salpêtrière Hospital, Sorbonne University, in Paris, France, in January, 2024. The donor, located in the French West Indies, was a man aged 48 years, declared brain dead 3 days after an intracerebral haemorrhage. Echocardiography and coronary angiography were unremarkable. The heart was transported to Paris in the cabin on a commercial airline flight. Preservation (12 h 6 min) and perfusion (10 h 32 min) was uneventful, despite severe turbulence. The recipient, a man aged 70 years, with terminal ischaemic cardiomyopathy and chronic renal insufficiency (estimated glomerular filtration rate [eGFR] 24 mL/min per 1·73 m2) was consented and registered on the PEGASE trial waiting list (NCT06035991). After transplantation, the heart immediately had normal biventricular function without any graft dysfunction. This transplant marks the first instance of a donated heart being flown across the Atlantic, covering a distance of 6750 km from the French West Indies to Paris, a feat previously unimaginable in organ transplantation. The success achieved in this instance, in which distance and transport time are no longer limiting factors, has the potential to redefine the landscape of heart transplantation with unlimited geographical procurement and lowered time constraints. In recent years, the concept of using a machine to continuously pump an oxygenated fluid through the heart during transport has been under evaluation in clinical trials. No studies have, however, explored extreme (>10 h) transport times. This case is the inaugural event in an investigator-initiated clinical study, approved by ethics committees and regulatory authorities, investigating the feasibility of preserving donor hearts using hypothermic oxygenated perfusion for extended transport times. The aim of the project is not to achieve a feat, but to set up a sustainable cardiac donor programme in the French West Indies. Beyond the proof of concept of prolonged heart-graft preservation, the initiative wanted to make this operation reproduceable and keep transport costs bearable. The successful outcome of this report may be a monumental breakthrough in heart transplantation allowing for increased access to unused donor hearts, that can now be used and safely transported across vast distances. Additionally, it suggests a reorganisation of transplant procedures, allowing for better scheduling and expert-led surgeries. These changes might improve overall outcomes and redefine the approach to cardiac transplant care. https://lnkd.in/dKbT9UZj
Successful heart transplant after 12 h preservation aboard a commercial flight
thelancet.com
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Dear Colleagues, A recent publication in the American Journal of Case Reports by authors from Mayo Clinic, Phoenix, AZ, USA, sheds light on the practical implications of paradoxical air embolism (PAE) during liver transplantation. The case study presents a 60-year-old patient with non-alcoholic steatohepatitis cirrhosis who experienced hemodynamic collapse due to PAE, diagnosed intraoperatively using transesophageal echocardiography. The study highlights the importance of considering PAE as a potential cause of hemodynamic instability in liver transplantation, especially when air is detected in specific cardiac chambers. This valuable insight can aid medical professionals in promptly identifying and managing PAE during liver transplantation procedures. The complete report is now available on the American Journal of Case Reports webpage. | https://lnkd.in/dfH3t-W6
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