UPMC Physician Resources’ Post

Did you know? A first-of-its-kind study led by UC Irvine, has revealed a new culprit in the formation of brain hemorrhages that does not involve injury to the blood vessels, as previously believed! Researchers discovered that interactions between aged red blood cells and brain capillaries can lead to cerebral microbleeds, offering more profound insights into how they occur and identifying potential new therapeutic targets for treatment and prevention. Co-corresponding author Dr. Mark Fisher, professor of neurology at UCI School of Medicine, states, “our findings may have profound clinical implications, as we identified a link between red blood cell damage and cerebral hemorrhages that occurs at the capillary level.” Want to learn more? Read the full article: https://bit.ly/3R663UC Beckman Laser Institute #UCIBLIMC #UCIBeckmanLaserInstitute #research

Revolutionizing Early Detection: Researchers from UCL and Moorfields Eye Hospital have identified markers that can detect Parkinson's disease in patients an average of seven years before clinical symptoms appear. AI-Powered Insights: This groundbreaking discovery was made possible through the use of artificial intelligence (AI) to analyze eye scans, revealing subtle markers of Parkinson's disease. Retinal Imaging for Parkinson's Diagnosis: The study identified thinner retinal layers associated with an increased risk of Parkinson's disease. Further studies are needed to explore the mechanism and diagnostic potential of retinal imaging for Parkinson's. Scalability: Optical coherence tomography (OCT) scans, used in this research, are scalable, non-invasive, cost-effective, and quicker than traditional brain scans, making them a promising tool for predictive analysis. Multiple Health Conditions: Eye scans have previously unveiled signs of other neurodegenerative conditions, cardiovascular issues, and diabetes, making them a valuable tool for early diagnosis.   Study Published in Neurology®: [DOI: https://lnkd.in/eQnAkzg3] Image source-euronews.net #Retina #aiapplications #parkinsonsdisease #biomedicalengineering #interdisciplinary #ophthalmology

wonderfull advancements in Quantum Biology will lay foundation for more and more modern medical advancements and epigenetics, here is the evidance for that... #epigenetics #biology #medicaladvancements #Quantum #Quantumbiology

✍️Neurons aren't the only cells that make memories in the brain 🧠 ♦️KEY insights to learn from this post are: ↪️Blood-vessel-making cells called pericytes collaborate with neurons to form long-term memories in the mouse brain. ↪️Memory formation has long been attributed to the complex interactions among neurons. ↪️However, recent #research sheds light on the active role played by pericytes, specialized cells located on the walls of blood vessels. ↪️Pericytes were once regarded as mere supporters of vascular function, regulating blood flow and maintaining the blood-brain barrier. ↪️Understanding the collaboration between pericytes and neurons opens new avenues for exploring the potential therapeutic interventions in neurological disorders. ↪️This study provides a new view of the biology of memory — though more research is needed (especially in humans ) to further understand the roles of pericytes and the vascular system in memory and its diseases. References: livescience..com Video source: Hashem Al-Ghaili #neurons #pericytes #collaboration

Knowledge is power.

The collaboration between pericytes and neurons extends to the maintenance of the blood-brain barrier (BBB), a protective barrier that controls the passage of substances between the bloodstream and the brain. Pericytes actively participate in BBB regulation, influencing the entry of molecules crucial for synaptic plasticity, a fundamental process in long-term memory

The Society for Neuroscience Meeting is always Brain Stimulating and Nerves Firing, and we are thrilled to play a part in the wealth of exciting new discoveries that will be presented at the #sfn2023 Annual Meeting in #washingtondc , November 12th through 16th. Be sure to attend the Cardiovascular Regulation session to learn how #heart monitoring is pointing to potential pathways of #anxiety treatment. Nicholas Conley and associates from the laboratory of John Campbell (University of Virginia) will show how dorsal motor vagal neurons can suppress heart rate and anxiety-like behavior in #laboratory animals (https://lnkd.in/ehx794Fu).  ECGenie: Straight from the heart! https://lnkd.in/edigRK2r And if you are more brain and less heart, then pay attention to new research being presented by the laboratories of Lauren Jantzie and Shenandoah Robinson at Johns Hopkins University.  Xianyi Jia and colleagues will present Infantile Post-infectious #hydrocephalus Causes Gait Deficits in Juveniles in a #preclinical Rat Model (https://lnkd.in/eUZ_bbS5). DigiGait: See HOW they run! https://lnkd.in/eEsskBjR Swing by our Exhibit #2329 to appreciate the latest innovations to non-invasively gather #digitalbiomarkers of #cardiovascular and #neuromuscular function from your #translationalresearch models. Happy travels! The Mouse Specifics Team #3rs #braininjury #als #parkinsonsdisease #huntingtonsdisease #alzheimersdisease #neurodegeneration #autism #rarediseases #data #healthcare

I'm pleased to announce the addition of Andrew Mayer, Ph.D., Professor of Translational Neuroscience, The Mind Research Network, University of New Mexico, to the speaking faculty for the 14th Annual Traumatic Brain Injury Conference (www.tbiconference.com) on May 2-3, 2024 in Washington, DC. In his presentation, Dr. Mayer will discuss prognostication in pediatric mild traumatic brain injury. Predicting outcomes in mild traumatic brain injury is challenging given heterogeneities in injury biomechanics, individual host factors, and the current reliance on subjective self-report measures (i.e. gold standard). Prognostication in children is further complicated by the developing brain, which rapidly changes at different rates throughout middle childhood and adolescence. The presentation will describe recent attempts to understand how prognostication is affected by psychometric properties of self- and parental report, and how imaging and blood-based biomarkers may improve diagnosis and prognostication. Finally, he will discuss how large animal models can be used in parallel with clinical studies to shed light on injury biomechanics and mechanisms of injury. Join us at this year's event, where speakers will be sharing research on a variety of subjects relating to improved diagnosis, treatment and outcomes for TBI patients. #tbi #traumaticbraininjury #braininjury

Please help us welcome Kan Liu, MD, Assistant Professor of Medicine, WashU Cardiovascular Division.⁠ ⁠ Dr. Kan Liu has worked on patient care, teaching and research in cardiovascular medicine for more than 15 years. His clinical activities include outpatient and inpatient cardiology, echocardiographic and cardiovascular imaging services. His research focuses on using deep convolutional neural networks to automate imaging data analysis, and establishing novel echocardiography processing models to support imaging diagnostic networks and enhance rural health engagement. He is particularly interested in data visualization on spatiotemporal imaging features to optimize disease phenomapping and classification, investigate pathophysiology and develop personalized treatment in ischemic and non-ischemic cardiomyopathies. ⁠ Learn more by clicking the link > https://lnkd.in/gcz-2aA9

#traumaticbraininjury #bloodflow #mitochondrial #model Characteristics of traumatic brain injury models: from macroscopic blood flow changes to microscopic mitochondrial changes https://lnkd.in/g6hsAPmm Controlled cortical impingement is a widely accepted method to induce traumatic brain injury to establish a traumatic brain injury animal model. A strike depth of 1 mm at a certain speed is recommended for a moderate brain injury and a depth of > 2 mm is used to induce severe brain injury. However, the different effects and underlying mechanisms of these two model types have not been proven. This study investigated the changes in cerebral blood flow, differences in the degree of cortical damage, and differences in motor function under different injury parameters of 1 and 2 mm at injury speeds of 3, 4, and 5 m/s. We also explored the functional changes and mitochondrial damage between the 1 and 2 mm groups in the acute (7 days) and chronic phases (30 days). Our results provide reliable data support and evaluation methods for promoting the establishment of standard mouse controlled cortical impingement model guidelines.