UCB’s Post

Here is our recent report documenting a remarkable metabolic shift in the human hippocampus affected by temporal lobe epilepsy. This finding may indicate that the TLE hippocampus entails an active metabolic pool producing several anionic phospholipids at the expense of cationinc phospholipids, owing to the dysregulation of the Kennedy and CDP-DG pathways. Click the following link to know more about this exciting work. https://lnkd.in/ddU_g6Z2

#Antidepressant-like effects of #psychedelics in a chronic despair mouse model: is the 5-HT2A receptor the unique player? | Neuropsychopharmacology (nature.com) This is a great piece of work that also found that "#daily #microdosing administration of psychedelics to CDM mice and showed that this protocol is as #efficient as a single dose administration to induce antidepressant-like effects. Furthermore, this protocol did not result in an increased food consumption in psilocybin-treated mice, as observed after a single administration. This observation, together with the lack of HTR after sub-chronic microdosing psychedelic administration, supports its benefit over a single dose administration".... Will be interesting to see if this translates in humans.

“Customers prefer Jess because it has higher throughput than western blot. Furthermore, Jess is faster and more reliable in terms of quantification and allows us to use low sample volumes, for example, difficult-to-obtain samples such as derived neurons of iPSC.” https://bit.ly/3wGFNrV #Westernblot #ProteinAnalysis #LabLife #ResearchMethods

In this The Times article by Anna Maxted, Monty Lyman cites 2021 research by APC's Prof John Cryan which transplanted the microbiomes of young mice into elderly ones and reversed age-related immune changes in their brains and improved cognition and age-related anxiety. #microbiome #research #gutbrainaxis Read Article: https://bit.ly/43PebgP

Excited to announce the publication of our latest review article in Frontiers in Cell and Developmental Biology. Authored by 𝗖𝗵𝗿𝗶𝘀-𝗧𝗶𝗮𝗻𝗻 𝗥𝗼𝗯𝗲𝗿𝘁𝘀, khatereh Saei, 𝗗𝗿. Jim Davie, 𝗗𝗿. Mojgan Rastegar and myself, this comprehensive review explores the general etiology of selected rare neurological diseases, including Rett Syndrome, Prader-Willi Syndrome, Rubinstein-Taybi Syndrome, Huntington’s disease, and Angelman syndrome, with respect to their associated aberrant epigenetic mechanisms. Read the full article here: https://lnkd.in/gkvApcWa

Research demonstrates that the functional mushroom lion's mane has neuroprotective properties. The bioactive fungal compounds show efficacy in reversing neurological inflammation and encouraging neuron regeneration. Specifically, studies indicate lion's mane promotes neural growth factor production, stimulates neuron regeneration, and reduces inflammation in the brain. Some integrative clinics now incorporate lion's mane supplements early on to support cognition in neurodegenerative prevention protocols. Join me in exploring the world of functional mushrooms and their neuroprotective wonders. #brainoptimization #mushrooms #nootropics

What happens to the brain when we age? The dynamic nature of neuronal connectivity in both the #brain and the peripheral nervous system involves constant changes driven by the formation and elimination of connections. As we #age, the elimination of axons and connections significantly impacts brain function and the regulatory control of various organs. Approaches aimed at improving neuronal connectivity could enhance functionality in both the brain and other organs. Join our #Healthy #Longevity #webinar on 14 Dec with Professor Andrea Maier and our special guest Dr Felipe Court, Professor at the Center for Integrative Biology, Universidad Mayor, Chile, Director and Principal Investigator at the Center for #Geroscience, Brain Health, and Metabolism (GERO) and the Chief Scientific Officer of Momentum Therapeutics, as they discuss central and peripheral innervation as a strategy to prevent and reverse age-related conditions. Register your interest at https://bit.ly/3F0IlRd

The new research from a team of scientists from Trinity College Dublin and investigators from research centre FutureNeuro, found that disruption to the integrity of the blood vessels in the brains of people suffering from long Covid and brain fog #covid #covid19 #covid19impact #longcovid #research #brainfog #covidimpact #covid19research #hyperactive #immunesystem

Stanley Prusiner was awarded the 1997 Nobel Prize in Physiology or Medicine for discovering prions and elucidating the underlying principles of their mode of action. Prions, typically harmless proteins, can transform into unstable conformations, leading to harmful particles, and causing deadly dementia-related brain diseases in humans and animals. His discovery offers crucial insights into the biological mechanisms of dementia-related diseases like Alzheimer's, paving the way for drug development and new medical treatment strategies. To uncover more about the research - https://bit.ly/3TRzJGV. . . . #nobelprize #prions #mymedicalpanel #healthcare #healthcareresearch #medicine #physiology #medical #doctors #discoveries #medicalresearch

Fatigue is the loss of energy or motivation to engage in effortful activity. Everyone experiences fatigue at some point in their lives, but fatigue can become pathological in many patients with neuropsychiatric conditions or neurological diseases. Despite the prevalence of fatigue in patients and its debilitating effects on their day-to-day lives, the biomedical community lacks a deep understanding of the underlying mechanisms of fatigue and how to treat it. Johns Hopkins biomedical engineering Ph.D. candidate Michael Dryzer studies fatigue in healthy people and patients with neurodegenerative disease and shares his thoughts on the state of the field. https://bit.ly/4etzOrp