Hear from Christian Wolff, our head of epilepsy discovery research, exploring the underlying disease biology in epilepsies in Drug Discovery Online. #epilepsy #innovation Read more https://lnkd.in/eFk3rB-w
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🔬 Exciting News in Epilepsy Research! 🧠 Researchers at the Francis Crick Institute, UCL, and MSD have uncovered a potential treatment target for a genetic type of epilepsy. Their groundbreaking work opens new doors in understanding and combating this condition. Science making strides for a brighter future! Read the full story here: https://bit.ly/3uW1IL2 Credit: The Francis Crick Institute #EpilepsyResearch #MedicalBreakthroughs #ScienceInnovation #Epilepsy #CDD #meded #eMednews
Novel therapeutic target for uncommon infantile epilepsy - eMedNews
https://emed.news
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Developmental Biologist | Lecturer of Bioscience | University Centre Shrewsbury | University of Chester | Programme Lead Stem Cells and Regenerative Medicine
Lovely research identifying calcium channel activity changes in childhood epilepsy. Researchers used stem cell derived neurons to translate the model from mouse to humans #stemcells #stemcellresearch #epilepsy #diseasemodel #biomedicalresearch
Researchers at the Crick, UCL and MSD have identified a potential treatment target for a rare genetic type of childhood epilepsy. Read more about the study from Marisol Sampedro Castaneda and Sila Ultanir 👇 https://lnkd.in/eNdxQRiV
New therapeutic target for rare type of childhood epilepsy
crick.ac.uk
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Assistant Professor Research | PhD in Neurobiology | Senior Scientist specializing in Neurodegeneration
Check out this insightful review on how BDNF-TrkB signaling influences mitochondrial function and its role in neurodegenerative diseases like Alzheimer’s and Parkinson’s. The article highlights potential therapeutic strategies to enhance neuronal resilience and function. Read the full text here: https://rdcu.be/dOoly
BDNF-TrkB Signaling in Mitochondria: Implications for Neurodegenerative Diseases - Molecular Neurobiology
link.springer.com
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Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics Dysregulated glycerophospholipid metabolism in the brain is associated with neurodegenerative diseases. Here, the authors present a 4D lipidomics strategy that profiles glycerophospholipids at the sn-position-resolved level, revealing potentially altered remodeling pathways. https://lnkd.in/gbQhhm8v
Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics - Nature Communications
nature.com
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#Parkinson's disease: connecting #mitochondria to #inflammasomes:- •#parkinsonsdisease (PD)-associated #neurotoxins and #mutations induce #mitochondrial #fission in vitro. •#Inducible mitochondrial fission #promotes #myeloid #cell #expression of #proinflammatory #mediators such as the #inflammasome #substrate #pro-IL-1β. •Emerging evidence highlights the #microglial #NLRP3 #inflammasome as an important driver of #PD #pathology. •#Pharmacological #inhibition of either #mitochondrial #fission or #NLRP3 function has provided #neuroprotective benefit in several rodent models of PD. •#Activated #microglia foster a #neurotoxic, #inflammatory environment in the #mammalian #central #nervous #system (CNS) that drives the #pathology of #neurodegenerative diseases including #Parkinson's disease (PD). •Moreover, #mitochondrial fission promotes #microglial inflammatory responses in vitro. •Given that the #NLRP3 #inflammasome and #mitochondria are central regulators of both #inflammation and PD, we explore potential functions for the #NLRP3 #inflammasome and #mitochondrial dynamics in #PD. •Specifically, we propose that #inducible #microglial #mitochondrial #fission can #promote #NLRP3-dependent #neuroinflammation in #hereditary and #idiopathic PD. •Further in-depth exploration of this topic can prompt valuable discoveries of the underlying #molecular mechanisms of PD #neuroinflammation, identify novel candidate #anti-inflammatory #therapeutics for PD, and ideally provide better outcomes for PD patients. #parkinsonsdisease #neurodegenerativediseases #neuroinflammation #inflammation #NLRP3
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Former Deputy Minister, Ministry of Youth & Sport - HRD & HRM, EG | Founder & CEO @ HUMAN LLC | Assistant Professor of Biotechnology @ Franklin Cummings Tech
Honored to share our recent publication on epilepsy research, where I led the metabolomics analysis, focusing on SCFAs. This research, conducted during my tenure at Texas A&M University, aims to illuminate the role of gut microbiota in epilepsy's pathogenesis and treatment. I believe this series of studies will pave the way for groundbreaking advancements in epilepsy management. #EpilepsyResearch #GutMicrobiota #Metabolomics #TexasAM
Behavioral Comorbidities Treatment by Fecal Microbiota Transplantation in Canine Epilepsya Pilot Study of a Novel Therapeutic Approach
frontiersin.org
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Training and Development - Organizational Leadership - Employee Onboarding - ERG Event Planning Lead - Health & Wellness
The identification of a new treatment target for genetic epilepsy is a promising development that could potentially improve outcomes for individuals living with this condition. Learn more about this groundbreaking research and its implications for patient care. #EpilepsyAwareness #HealthcareResearch
Researchers identify new treatment target for genetic epilepsy
https://pharmatimes.com
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The identification of a new treatment target for genetic epilepsy is a promising development that could potentially improve outcomes for individuals living with this condition. Learn more about this groundbreaking research and its implications for patient care. #EpilepsyAwareness #HealthcareResearch
Researchers identify new treatment target for genetic epilepsy
https://pharmatimes.com
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Professor of Epilepsy Genetics & Head of Dept. of Epilepsy Genetics and Personalized Medicine at the Danish Epilepsy Centre, Filadelfia / University of Southern Denmark I Epilepsy I Genetics I Precision Medicine
Publication alert 📢 Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function #GABRB2 variants ‼️ Based on our extensive molecular and clinical data, we have developed a diagnostic flowchart that utilises clear clinical biomarkers to predict the pathogenicity of newly identified GABRB2 variants. This tool will be useful in improving diagnosis and achieving #PrecisionMedicine for future patients with GABRB2 variants 💜 Excellent work by Nazanin Azarinejad, Philip Ahring, Vivian Liao Han Chow Chua Sebastian Ortiz De la Rosa Katrine M Johannesen Alessandra Rossi Stéphane Auvin, MD, PhD, FAES Sarah Weckhuysen & many more 👏 #Epilepsy 💜 #Genetics 🧬 #GABAA Justin LeBlanc Monica Joanna Elnekaveh GABAA Receptor Alliance Cure GABA A Variants Agustina Fernandez Giambruno Jillian Provost Miranda Cox Filadelfia Epilepsihospital og sociale tilbud ERN EpiCARE - Rare and Complex Epilepsies Lundbeckfonden / Lundbeck Foundation
Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function GABRB2 variants
thelancet.com
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Diagnosed a child with a #GABRB2 variant? Check out our recent work on the gene including a diagnostic flowchart to predict functional effect! Great work by Nazanin Azarinejad Rikke Steensbjerre Møller and collaborators 💪🏻 #GABAAR #precisiondiagnosis #epilepsygenetic
Professor of Epilepsy Genetics & Head of Dept. of Epilepsy Genetics and Personalized Medicine at the Danish Epilepsy Centre, Filadelfia / University of Southern Denmark I Epilepsy I Genetics I Precision Medicine
Publication alert 📢 Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function #GABRB2 variants ‼️ Based on our extensive molecular and clinical data, we have developed a diagnostic flowchart that utilises clear clinical biomarkers to predict the pathogenicity of newly identified GABRB2 variants. This tool will be useful in improving diagnosis and achieving #PrecisionMedicine for future patients with GABRB2 variants 💜 Excellent work by Nazanin Azarinejad, Philip Ahring, Vivian Liao Han Chow Chua Sebastian Ortiz De la Rosa Katrine M Johannesen Alessandra Rossi Stéphane Auvin, MD, PhD, FAES Sarah Weckhuysen & many more 👏 #Epilepsy 💜 #Genetics 🧬 #GABAA Justin LeBlanc Monica Joanna Elnekaveh GABAA Receptor Alliance Cure GABA A Variants Agustina Fernandez Giambruno Jillian Provost Miranda Cox Filadelfia Epilepsihospital og sociale tilbud ERN EpiCARE - Rare and Complex Epilepsies Lundbeckfonden / Lundbeck Foundation
Distinct neurodevelopmental and epileptic phenotypes associated with gain- and loss-of-function GABRB2 variants
thelancet.com
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