Tulane University School of Medicine’s Post

🔊 #D2RProjectSpotlight: "Lung-Targeted Lipid Nanoparticles to Deliver Anti-Viral RNA against Respiratory Viral Infection" led by Guojun Chen, McGill University. Co-Investigator: Rongtuan Lin (McGill University) Collaborator: Zhenlong Liu (Ebovir Biotechnologie Inc) This project aims to develop lipid nanoparticles (LNPs) that can deliver anti-viral RNAs directly to the lungs where viral infections occur. 🔗 Learn more: https://buff.ly/3VClky6 #DNA2RNA #nanoparticles

The #callforpaper invites submissions on current research in virology and retrovirology. Topics may include #viralpathogenesis, host-virus interactions, #antiviraltherapies, and #molecularmechanisms of viral replication. #oriele #clinicalresearch

🧬This paper investigates how viruses, specifically bacteriophages, manipulate the translation machinery of their hosts by modulating post-transcriptional modifications (PTMs) on transfer RNA (tRNA). 🔎Read more at: https://lnkd.in/d2k7Rrra #host #pathogen #RNA

With mosquito and tick-borne viruses increasing globally there is a need for reliable diagnostic assays. Traditional serology can be challenging due to cross-reactivity of patient antibodies among the flavivirus proteins. Using the non-structural protein NS1, secreted by Flaviviruses is a more specific antigen for detecting immune responses. At The Native Antigen Company you can choose from a comprehensive selection of mammalian-expressed NS1 proteins suitable for generating highly specific and well characterized antibodies available for various flaviviruses. Interested in learning more about these highly specific proteins? Click the link to get started today: https://hubs.ly/Q02Ppwzj0 #antibodies #flaviviruses #diagnostics

🔬 Innovative Study Sheds Light on Immune Collaboration Against Bacterial Threats 1.0 #CME A groundbreaking study by Andrew J Monteith, Jeanette M Miller, C Noel Maxwell, Walter Chazin, and Eric Skaar, offers insights into how our immune cells work in tandem to fight infections. 📌 Key Findings: S100A9-deficient neutrophils exhibit an increased production of mitochondrial superoxide when exposed to Staphylococcus aureus, leading to enhanced neutrophil extracellular traps (NETs). While these NETs do not increase neutrophil efficacy in isolation, they significantly boost macrophage ability to kill bacteria through increased phagocytosis and transfer of antimicrobial peptides. This mechanism has been shown effective against other pathogens like Streptococcus pneumoniae and Pseudomonas aeruginosa, highlighting a universal strategy enhancing antibacterial defense. https://lnkd.in/dUr2Vvw8 #Immunology #MedicalResearch #HealthcareInnovation #Neutrophils #Macrophages #BacterialInfections

The article "Pseudotyped Viruses: A Useful Platform for Pre-Clinical Studies Conducted in a BSL-2 Laboratory Setting" highlights the utility of pseudotyped viruses—viruses engineered with the envelope protein(s) of one virus and the core of another—in pre-clinical research. These viral pseudotypes are essential for studying viral entry mechanisms, screening antiviral compounds, and evaluating neutralising antibodies. Notably, they can be used in biosafety/containment level 2 (BSL-2/CL-2) laboratories, making basic virological research more accessible. This allows a broader range of research groups to study high-containment viruses, facilitating safer and more efficient research of highly pathogenic viruses. #virology #pseudotyping #COVID19 https://lnkd.in/dGgqt8hR

Happy to share our story on the discovery and characterization of a DNA glycosylase that provides antiviral immunity in bacteria, led by the brilliant Amer Hossain! We show that this glycosylase, Brig1, recognizes and excises a hypermodified DNA base within phage genomes that usually helps them evade host defense nucleases. Additionally, we showed Brig1 is a widespread immune effector and established a functional screening approach to identify more new immune systems like Brig1. Check out the story recently published at Nature Portfolio! https://lnkd.in/epPC8m78

Mechanism for Cellular RNA’s Role in Antiviral Immune Response Uncovered https://lnkd.in/gb-rkxQx Scientists from the University of Washington School of Medicine and Duke University have published a study that describes how RNA helps regulate antiviral signaling to help with the immune response to viral infections. The post [...]

🆕 Researchers have discovered a new class of drugs that could both prevent and treat future viral outbreaks – with a little help from the ATCC Biobank. > Using human cell lines provided by ATCC, scientists from Alberta University successfully tested 10 existing drug compounds against a number of viruses in the laboratory. > Among the strains whose genomic RNA levels were lowered by the drugs were SARS-Cov-2 and its fellow human coronaviruses HCOV-NL63 and HCOV-229E, plus Zika virus, and the Mayaro virus. > If planned human trials go well, the Alberta approach could be used to provide people with pills or nasal sprays to help prevent infection, and limit the contagion and severity of many future diseases. 🔬 ATCC is the world leader in virology research materials, and its products are distributed by LGC Standards in Europe and Africa. 📩 Drop me a message to learn more! #ScienceForaSaferWorld #VirologyResearch #Virology

Hello everyone! I’d like to share a biomedical illustration I created, depicting a phagocyte vs. a granulocyte. Both of these cells are examples of innate leukocytes, but they have two key differences! Firstly, granulocytes are significantly smaller than phagocytes and contain granules. These granules play a crucial role in the host's defense mechanisms during bacterial, viral, or parasitic infections, as they contain cytotoxic molecules that help neutralize threats. On the other hand, phagocytes are larger and operate through the recognition of pathogen-associated molecular patterns (PAMPs) using pattern-recognition receptors (PRRs) on their surface. When a phagocyte identifies PAMPs on the surface of a bacterium or virus, it "ingests" the microbe and degrades it. They have a voracious appetite for harmful invaders!