Increasing cases of cancer reported, highlights the necessity to investigate always all potential risk factors of cancer.
The concept of immunosenescence was first proposed by Walford in 1964 and is characterized by decreased adaptive immunity, decreased infection resistance, and increased autoimmune risk
In addition, a variety of factors can dramatically influence this status, such as genetics, exercise, nutrition, previous exposure to microorganisms, sex, and human cytomegalovirus infection.
It could therefore be possible to target the immune system of the elderly aiming to restore its competence .
There is a difference in innate and adaptive immune systems between young and elderly individual.
T cells are the main effectors of acquired immunity, and their compartment is heavily affected during aging, cumulating defects that can increase immune system damage, disease susceptibility, and the occurrence of malignant tumors in the elderly.
Immunosenescence is a process of immune dysfunction that occurs with age and includes remodeling of lymphoid organs, leading to changes in the immune function of the elderly.
Moreover, an important distinguishing feature is that the thymus gradually recedes and degenerates with age, resulting in a decrease in T cell output***
New approach aiming to restore thymus function and the production of T cells provides an effective strategy not only in immunosenesence.
Additionally, inflammation related to advanced age will produce a senescence-associated secretory phenotype (SASP), which also leads to immune system senescence
Intrinsic factors in immune system cells as well as potential extrinsic factors that are often overlooked can also cause immunosenescence and its complexity supports the idea that it will lead to the damage of immune systems and Interference with own host immune surveillance, are known to lead to the occurrence of various diseases.
* Cancer and decreased imunosurveillance due mrna technology
Adverse complications that may be associated also with the novel mrna technology used during COVID-19 are part of risks, thus need for early proactive depistage and guidance for all physicians in early and proactive surveillance, detection and adapted treatment..
🇬🇧 Atteint d’un cancer, #CharlesIII passe le flambeau au prince William et à la princesse Anne. Le palais de Buckingham a confirmé que le roi se retirait temporairement de ses engagements publics pour se concentrer sur son traitement. 👇
Le roi Charles III délègue ses fonctions | FranceSoir
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Wishing your team great success on this important journey. It's inspiring to see such dedication toward a vital cause. How did the team prepare for this challenge?