St. Peter's Health’s Post

In a study published in Science Advances, MCW scientists uncovered new insights into preeclampsia. Focusing on the syncytiotrophoblast (STB), a crucial placental cell layer acting as a barrier between the mother and foetus, the study explores how stressors might damage the placenta, potentially causing preeclampsia. This research sheds light on the complexities of this condition, offering valuable clues into its possible origins and paving the way for future diagnostic and treatment improvements. #Preeclampsia #WomensHealth #NeonatalHealth

Dr. Kimberly Gudzune, of The Johns Hopkins University School of Medicine in Baltimore presented this week at the American Association of Clinical Endocrinology (AACE) annual meeting, in a post hoc analysis of the SURMOUNT-1 trial, from MedPage Today. Dr. Gudzune notes of participants who failed to shed 5% of their body weight at 12 weeks, more than 90% ultimately achieved that clinically meaningful level of weight loss at 72 weeks. But only 30% dropped at least 15% of their body weight at 72 weeks, compared to 84% of the early responders – those who lost at least 5% at 12 weeks. Put another way, 1 in 6 of the early responders failed to lose at least 15% in weight at 72 weeks, compared to over two-thirds of the slow responders. My take – we should focus care upon early responders, in order to maximize benefit across a population; which is further exacerbated by cost, supply and access issues. https://lnkd.in/e4Hn2Vjv

#ECE2024 takes place on 11-14 May in Stockholm, Sweden - be sure not to miss the following Programme Highlights: • Hypoxia - Sir Peter Ratcliffe, FRS, FMedSci is a British physician-scientist who is trained as a nephrologist. Ratcliffe is best known for his work on cellular reactions to hypoxia, for which he shared the 2019 Nobel Prize in Physiology or Medicine with William Kaelin Jr. and Gregg L. Semenza. • From molecular biology to precision medicine in endocrine tumors: Are we there yet? - Constantine Stratakis (Greece) • GEOFFREY HARRIS AWARD LECTURE - Hypothalamic control of energy and glucose homeostasis - Jens Brüning (Germany) • EUROPEAN ENDOCRINE NURSE AWARD LECTURE - Transformation of German Endocrinology Assistants - Kathrin Zopf (Germany) • CLINICAL ENDOCRINOLOGY JOURNAL FOUNDATION AWARD LECTURE - Εarly menopause: is it a different entity than premature ovarian insufficiency? - Panagiotis Anagnostis (Greece) You can attend in person or via ECE@Home - find out more here: https://ow.ly/wJ4H50Qz8my #endocrinology #OurEndocrineCommunity

Call for Papers: Endometriosis and Polycystic Ovary Syndrome (PCOS) We are currently seeking comprehensive reviews, original research articles, and outstanding Editorials on Endometriosis and Polycystic Ovary Syndrome (PCOS). Topics of Interest: 🔔 Innovative Diagnostic Tools and Techniques 🔔 Pathophysiology and Molecular Mechanisms 🔔 Pharmacological Interventions and Non- Pharmacological Therapies 🔔 Fertility and Reproductive Outcomes 🔔 Surgical Approaches 🔔 Psychological and Quality of Life Aspects For detailed submission guidelines and to start the submission process, please scan the QR code in the image. #Gynecology #PCOS #Endometriosis #WomenHealth #Review #OriginalArticle #Editorial #GOCM #BMJ

📃Scientific paper: Pathophysiology of Female Reproduction and Clinical Management Abstract: The female genital system is made up of dynamic organs that change during the woman’s life cycle. Ovarian cycle consists of the growth and development of the ovarian follicle, its bursting, and transformation into the corpus luteum with relative production of estrogens and progesterone. The normal menstrual cycle is the result of the integration of the primary neuroendocrine complex (the hypothalamus–pituitary–ovarian axis) into a control system regulated by a series of peripheral mechanisms of feedback and nerve signals that result in the release of a single mature oocyte from a pool of hundreds of thousands of primordial oocytes. Alterations of these mechanisms can lead to pathological conditions and affect fertility of patients. Discover the rest of the scientific article on es/iode ➡️https://etcse.fr/robE9

In my daily wanderings, I am continually fascinated by the convergence of various medical disciplines—immunology, endocrinology, and neurology—into a cohesive whole. These three fields, in my view, constitute the backbone of health Yet, a comprehensive understanding of health also demands a deep dive into nutrition, hypersensitivities, and behavioral sciences. The integration of technology in these areas further enriches our approach. I am profoundly grateful for the journey thus far!

📃Scientific paper: Pathophysiology of Female Reproduction and Clinical Management Abstract: The female genital system is made up of dynamic organs that change during the woman’s life cycle. Ovarian cycle consists of the growth and development of the ovarian follicle, its bursting, and transformation into the corpus luteum with relative production of estrogens and progesterone. The normal menstrual cycle is the result of the integration of the primary neuroendocrine complex (the hypothalamus–pituitary–ovarian axis) into a control system regulated by a series of peripheral mechanisms of feedback and nerve signals that result in the release of a single mature oocyte from a pool of hundreds of thousands of primordial oocytes. Alterations of these mechanisms can lead to pathological conditions and affect fertility of patients. Continued on ES/IODE ➡️ https://etcse.fr/robE9 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

Examining the content of extracellular vesicles in the context of polycystic ovarian syndrome and endometriosis: in this concise review article, Cyntia Duval, Brandon Wyse at Create Fertility Centre and collaborators explored the roles of EVs in common gynecological diseases, particularly polycystic ovarian syndrome and endometriosis, highlighting their potential clinical implications https://lnkd.in/eScmnZTS They concluded that investigating EVs in ovarian follicles and their roles in polycystic ovarian syndrome and endometriosis enhances our comprehension of reproductive physiology and pathology. An article co-authored by Benjamin K. Tsang and Clifford L. Librach #extracellularvesicles #exosomes #biomarkers #endometriosis #Vesiculab

Ophthopedia Update:Understanding racial disparities of glaucoma: Purpose of review Increased prevalence, earlier onset, and more rapid progression to vision loss from glaucoma has demonstrated racial disparity in numerous studies over decades. Precise etiologies of these important differences among patients of African and Hispanic ancestral background have not been elucidated. This review focuses on currently available epidemiologic/population, genetic, socioeconomic and physiologic studies of racial disparities in this blinding disease. Recent findings In depth reviews of several landmark studies of glaucoma prevalence in various racial groups have highlighted potential challenges of lack of recruitment of diverse populations in genetic studies and clinical trials, challenges of racial stratification of subjects, and the impact of socioeconomic variables. Summary Through a more comprehensive analysis of racial disparities of glaucoma, both clinicians and researchers may provide more effective population screening and management with a holistic approach for individualized patient care to provide improved outcomes. Future studies of interventions in sociodemographic factors and genetic/physiologic variables that influence the prevalence, access, and consequential vision loss from glaucoma will be crucial to minimize/eliminate racial disparities and improve outcomes for all. #Ophthalmology #Eye #Ophthotwitter

How Does Radiation Effect the Endocrine System? https://lnkd.in/enViNNGf A literature study of radiation effect on endocrine system is described.Endocrine disorders are common to people who they are exposed to radiation, it develops of hormone dysfunction and neoplasms in the irradiated gland and require long-term follow-up. Herein we discuss effects of radiation on the endocrine system. #Radiation, #Endocrinology, #Prevention