Join our laboratory team in Gainesville! If you're a team player, dedicated to providing precise and dependable test outcomes in fields such as chemistry, hematology, immunology, virology, and toxicology, apply today! https://bit.ly/3VpAM12 #Hiring #FlJobs #HealthcareJobs #LabTech #LaboratoryTech #GainesvilleFl
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# Leveraging Drosophila melanogaster in Biomedical Research 🧬✨ Drosophila melanogaster is a potent preclinical model due to its short life cycle and cost-effective maintenance. With ∼75% homology to human disease-related genes, it has become a game-changer in innovative approaches for evaluating candidate molecules. The fruit-fly model serves as an invaluable tool to expedite functional research, shedding light on the intricate mechanisms underlying different diseases. 📲 Contact us or schedule a meeting here https://lnkd.in/dD9wkEPJ to learn more about our models (DMD, liver disease, diabetes, ocular disease, IBD, Tox and much more). 🛩 Let's accelerate progress in understanding pathologies and advancing biomedical knowledge with the powerful Drosophila model! 🚀🧠 #Drosophila #preclinical #metabolicsyndrome #diabetes #toxicology #pharmacology #servicesolutions #outsourcing #preclinicalmanager Pasquale Cocchiaro PhD, MBA
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📲 Contact us to learn more about our Drosophila models (DMD, liver disease, diabetes, ocular disease, IBD, Tox and much more). 🛩 Let's accelerate progress in understanding pathologies and advancing biomedical knowledge with the powerful Drosophila model! 🚀🧠 #Drosophila #preclinical #metabolicsyndrome #diabetes #toxicology #pharmacology #servicesolutions #outsourcing #preclinicalmanager PreClinic Pharmacology Services
# Leveraging Drosophila melanogaster in Biomedical Research 🧬✨ Drosophila melanogaster is a potent preclinical model due to its short life cycle and cost-effective maintenance. With ∼75% homology to human disease-related genes, it has become a game-changer in innovative approaches for evaluating candidate molecules. The fruit-fly model serves as an invaluable tool to expedite functional research, shedding light on the intricate mechanisms underlying different diseases. 📲 Contact us or schedule a meeting here https://lnkd.in/dD9wkEPJ to learn more about our models (DMD, liver disease, diabetes, ocular disease, IBD, Tox and much more). 🛩 Let's accelerate progress in understanding pathologies and advancing biomedical knowledge with the powerful Drosophila model! 🚀🧠 #Drosophila #preclinical #metabolicsyndrome #diabetes #toxicology #pharmacology #servicesolutions #outsourcing #preclinicalmanager Pasquale Cocchiaro PhD, MBA
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🔬 Exciting Developments in Toxicology: The Role of Non-Parenchymal Cells 🔬 Hello LinkedIn community, Today, we want to shed light on a fascinating area of toxicological research that’s gaining significant momentum: the use of non-parenchymal cells (NPCs). NPCs, including stellate cells, Kupffer cells, and sinusoidal endothelial cells, play a pivotal role in liver physiology and pathology. In toxicological studies, understanding their behavior is crucial for a more holistic view of drug-induced liver injury (DILI). Here’s why NPCs are so vital: Multi-faceted Functions: Unlike parenchymal hepatocytes, NPCs participate in immune responses, fibrosis, and the formation of the liver's microenvironment. Improved Predictive Models: Incorporating NPCs into liver models offers a more accurate prediction of hepatotoxicity, enhancing drug safety assessments. Biomarker Discovery: Studying NPCs helps identify new biomarkers for early detection of liver injuries, crucial for both clinical and pharmaceutical advancements. The integration of NPCs in in vitro models is revolutionizing how we perceive drug metabolism and hepatotoxicity. It's not just about hepatocytes anymore; NPCs are proving to be key players in liver toxicology. Let's discuss: How can we further integrate NPCs into current toxicological research models? What are the challenges and opportunities in NPC-based research? Excited to hear your thoughts and insights! #Toxicology #LiverResearch #NonParenchymalCells #DrugSafety #Pharmacology #BiomedicalResearch
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The combination of isogenic hepatocytes and NPCs in research models offers a more comprehensive approach to studying liver diseases and drug-induced liver injury (DILI). This integrative method enhances our understanding of liver biology and pathology, leading to better predictive models for drug safety and more effective therapeutic strategies. #Toxicology #LiverResearch #NonParenchymalCells #DrugSafety #Pharmacology #BiomedicalResearch
🔬 Exciting Developments in Toxicology: The Role of Non-Parenchymal Cells 🔬 Hello LinkedIn community, Today, we want to shed light on a fascinating area of toxicological research that’s gaining significant momentum: the use of non-parenchymal cells (NPCs). NPCs, including stellate cells, Kupffer cells, and sinusoidal endothelial cells, play a pivotal role in liver physiology and pathology. In toxicological studies, understanding their behavior is crucial for a more holistic view of drug-induced liver injury (DILI). Here’s why NPCs are so vital: Multi-faceted Functions: Unlike parenchymal hepatocytes, NPCs participate in immune responses, fibrosis, and the formation of the liver's microenvironment. Improved Predictive Models: Incorporating NPCs into liver models offers a more accurate prediction of hepatotoxicity, enhancing drug safety assessments. Biomarker Discovery: Studying NPCs helps identify new biomarkers for early detection of liver injuries, crucial for both clinical and pharmaceutical advancements. The integration of NPCs in in vitro models is revolutionizing how we perceive drug metabolism and hepatotoxicity. It's not just about hepatocytes anymore; NPCs are proving to be key players in liver toxicology. Let's discuss: How can we further integrate NPCs into current toxicological research models? What are the challenges and opportunities in NPC-based research? Excited to hear your thoughts and insights! #Toxicology #LiverResearch #NonParenchymalCells #DrugSafety #Pharmacology #BiomedicalResearch
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Clinical Laboratory Services Market Size, Share & Trends Analysis Report By Specialty (Clinical Chemistry Testing {Routine Chemistry Testing, Endocrinology Chemistry Testing, Therapeutic Drug Monitoring (TDM) Testing, Specialized Chemistry Testing, Other Clinical Chemistry Testing}, Microbiology Testing {Infectious Disease Testing, Transplant Diagnostic Testing, Other Microbiology Testing}, Hematology Testing, Immunology Testing, Cytology Testing, Genetic Testing, Drug of Abuse Testing), By Provider (Independent and Reference Laboratories, Hospital-based Laboratories, Nursing and Physician Office-based Laboratories), COVID-19 Impact Analysis, Regional Outlook, Growth Potential, Price Trends, Competitive Market Share & Forecast, 2022 - 2028 Get A Sample Copy of This Report: https://lnkd.in/dQBdpcan Top Players/Manufacturers: A.P. Moller Holding Unilabs Abbott ACM MEDICAL LABORATORY INC-LONG POND Agena Bioscience Alere Toxicology Plc. AlSalam Specialist Hospital amedes-Gruppe American Medical Laboratories ARUP Laboratories Asuragen. BD Big South Fork Medical Center Bio-Rad Laboratories Biocept, Inc. bioMérieux Bio Reference Laboratories Inc CENTOGENE CERBA HEALTHCARE Charles River Laboratories Clinical Laboratory Services, Inc. Clinical Pathology Laboratories Southeast Clinical Reference Laboratory. DaVita HealthCare Partners DaVita Kidney Care Diversified Medical Healthcare Doctors Connection DOCTORS LAB - Independent Clinical Laboratory Enzo Biochem Inc Enzo Life Sciences, Inc. Eurofins Scientific Finland Oy Evexia Diagnostics Exosome Diagnostics. F. Hoffmann-La Roche Ltd Fresenius Medical Care GC Cell Genoptix, Inc. Genova Diagnostics GRAIL Great Ormond Street Hospital for Children NHS Foundation Trust
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SoHo™ Telemetry System: DSI's New Evolution of Preclinical Implants for Temperature and Activity Infectious Disease • Measure temperature to better understand the effects of drug therapy and disease. • Confidently acquire real-time data from challenging Biological Safety Level (BSL) environments with a miniature hardware footprint. • Areas include vaccine development, fever, and trigger-to-treat studies. Neuroscience • Conduct longitudinal studies with the same subject; allowing for quantification of behavioral and physiologic change over time. • Add quantitative analysis of endpoints to studies. • Monitor temperature and activity in behavioral assays such as treadmills, mazes, and operant conditioning boxes. • Areas include stress and pain, and social behavior. Other Areas of Concentration • Basic Research • Hibernation and torpor • Exercise • Thermoregulation • Circadian Rhythm • Oncology • Reproductive studies Safety • Drug Development • Metabolism • Environmental • Toxicology #SoHoTelemetrySystem #Toxicology #researchscience #preclinicalimplants #SOT2024 #ToxExpo
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Human Organ Chips are revolutionizing drug discovery and toxicology testing as ethical alternatives to animal models. Read more about this innovative technology in the review article from the Wyss Institute at Harvard University, published in Pharmacology Research & Perspectives : https://lnkd.in/gSh_CzMa #OrganChips #DrugDiscovery #ToxicologyTesting #AnimalAlternatives #InnovativeTechnology #BiomedicalEngineering #PharmacologyResearch #Pharmacology
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At Applied Pathology Systems, our dedication lies in aiding our clients in their fight against diseases. Through collaborative partnerships, we contribute to groundbreaking research for companies by offering essential histopathology services, including general histology, immunohistochemistry, pathology evaluations, and more. Through our swift turnaround time (TAT) and efficient one-on-one communication, our team guarantees meticulous attention to every detail, ensuring that projects are accomplished to complete satisfaction. #histology #histopathology #pathology #biotechnology #biotechnologyindustry #pharmaceutical #pharmaceuticalindustry #researchanddevelopment #researcher #research #cancerresearch #immunology #toxicology #immunohistochemistry #antibody
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A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge New study in Basic & Clinical Pharmacology & Toxicology aimed to characterize patients with low suPAR (a proxy for disease burden) who died within 90 days of hospital discharge. It found that patients with low suPAR who died had other risk factors explaining their morbidity and mortality risk than what was reflected by their suPAR level including high age, medication use, and FI-OutRef (an index of frailty based on a standard panel of laboratory tests). This suggests that the described patient characteristics have important implications for clinical care, and future studies must determine which factors that contribute the most to potential algorithms when stratifying patients based on their risk of adverse clinical outcomes. Study conducted by Louise Westberg Strejby Christensen, Esben Iversen, Aino Leegaard Andersen, Anne Byriel Walls, Line Jee Hartmann Rasmussen, Ove Andersen, Thomas Kallemose and Morten Baltzer Houlind. Read the full paper here: https://lnkd.in/deE3dsgQ
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Publication on the safety and high tolerability of the oncolytic virus Rigvir Oncolytic virus preclinical toxicology studies (Journal of Applied Toxicology) The search for treatments as safe as possible is a priority in medical care, especially in cancer care, where therapies often go hand in hand with severe side effects. Oncolytic virotherapy is promising in both safety and efficacy. This article summarizes the preclinical toxicology studies of several oncolytic viruses in different stages of development. Considering that the adverse events were mostly minor and reversible, it is concluded that oncolytic viruses have low toxicity and good tolerability. Regarding basic toxicology studies, Rigvir, even at the highest dose tested, showed high tolerability and did not induce any severe adverse event, unlike some of the genetically modified viruses. Rigvir proves once again that it is the safest and most gentle virus in the world. View publication: https://lnkd.in/g-sy92ga #virotherapy #oncolyticvirotherapy #virotherapycenter #rigvir #oncolyticvirus #cancercare #cancertreatment #cancerawareness
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