Profile Areas of RWTH Aachen University’s Post

Excited to share that our latest research paper titled "Effect of Nasal Inhalation on Drug Particle Deposition and Size Distribution in the Upper Airway: With Soft Mist Inhalers" has been published in the Journal of Annals of Biomedical Engineering. In this study, we delved into the intricate dynamics of how a combination of nasal and oral inhalation impacts the fate of drug particles emitted from soft mist inhalers. Our findings shed light on crucial aspects of drug delivery and have significant implications for optimizing treatment efficacy. The results of this study can be applied to in vivo studies. Combining oral and nasal inhalation (with an Oral/Nasal = 1 ratio suggested) while using soft mist inhalers helps to lower the drug deposition inside patients' mouth-throat airways. I'm immensely grateful to my supervisors, Dr. Leila Pakzad, Ph.D, P.Eng. and Dr. Pedram Fatehi, PhD, P. Eng, for their invaluable guidance and support throughout this research endeavor. Curious to learn more? Check out the full paper here: https://rdcu.be/dBWYa #BiomedicalEngineering #drugdelivery #Aerosol #SoftMistInhalers #NasalInhalation #HumanRespiratoryTract

Check out the recent Bruker BioSpin “customer insight” article, “Imaging Serves as a Scientific Hub to Unite Preclinical and Clinical Research,” to learn how Prof. Chris Flask, PhD, and his team are uniting #preclinical and #clinical research in The Case Center for #Imaging Research at #CWRU! Download the article here: https://lnkd.in/e3uYxA5r

Ultrasound for Drug Activation 🔊 A new research network between the DWI – Leibniz-Institut für Interaktive Materialien, Uniklinik RWTH Aachen, and RWTH Aachen University is being established in Aachen. 👍 In this innovatively structured initiative, the ACTISONO Leibniz ScienceCampus (Sonopharmacology – Activation of Drugs Through Ultrasound), researchers from chemistry, biology, medicine, and engineering are set to develop novel technologies for the activation of pharmaceutical ingredients using ultrasound. The Senate of the Leibniz Association voted in favor of establishing the first ScienceCampus in Aachen. The researchers will work together for an initial period of four years. The project is set to receive funding in the amount of around 3.6 million euros. The scientists’ vision and goal is to use ultrasound as an external trigger to control the activity of different classes of active substances. They thus strive to create new possibilities in the treatment of diseases such as bacterial infections or liver damage. In the future, patients should be able to administer drugs precisely in the regions of the body where they are needed in order to minimize side effects. 🙌 “We are extremely pleased to have the opportunity to create a new interdisciplinary field of research in the Leibniz ScienceCampus. With this project, we want to train new specialists and contribute to the well-being of patients,” said Professor Andreas Herrmann, spokesperson for the Leibniz ScienceCampus and Scientific Director of the Leibniz Institute in Aachen. 😀 Further information: ➡ https://lnkd.in/epqQWabX 📷: DWI/Hannes Woidich #Ultrasound #researchers #chemistry #biology #medicine #engineering #technology #medicine #science #ScienceCampus Fabian Kiessling Laura De Laporte

Ora Biomedical, Inc. secured The National Institutes of Health SBIR Phase I grant of $324,240 for EleGantry, an innovative system enhancing longevity drug discovery. This technology promises to revolutionize invertebrate research, particularly in longevity studies. Why might Ora Biomedical have been selected for this grant? → Pioneering approach to longevity biotechnology → Focus on improving research rigor and reproducibility → Innovative integration of software and hardware solutions → Potential to accelerate drug discovery in the longevity field → Alignment with NIH's mission to advance medical research Congratulations to Ora Biomedical on this significant achievement in pushing the boundaries of longevity science! https://lnkd.in/gA5gBsvg #bioscience #biomedical #science

Happy to share our latest review paper entitled "Light-Responsive Nanoassemblies: Advancing Biomedical Innovation" published in Advanced Functional Materials. This review paper is a great work by my PhD student Chin Siew Sia, which discussed the various light sources that could be utilized to manipulate state-of-the-art nanomaterials for biomedical applications. Read more at https://lnkd.in/gV2BpS67

Have you ever heard about carboxymethyl chitosan based hydrogels? This comprehensive review explores the versatile applications and cellular mechanisms of carboxymethyl chitosan hydrogels in biomedicine. We also provided an in-depth analysis of these hydrogels' biochemical properties, including their biocompatibility, controlled release capabilities, and antimicrobial efficacy, while also delving into their effects on key cellular processes like angiogenesis, inflammation, and collagen deposition. I'm so grateful to Karol Kłosiński and Radosław Wach for their support and for giving me this opportunity, as well as to Damian Kołat, PhD and Żaneta Kałuzińska-Kołat, PhD and Mateusz Kciuk, who guide me through my scientific journey. I also want to express my gratitude and congratulate Piotr Gromek, Katarzyna Grabowska and Julia Gałęziewska for their work and dedication. It was a pleasure working with you, as always. Read the full article here: Molecules, MDPI (IF: 4.2) website: https://lnkd.in/eu3CrKjz #Chitosan #Hydrogels #Biomedical #Biotechnology #Research

#Perspective Academic User View: Organ-on-a-Chip Technology, by Mathias Busek, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Ludivine Delon and Stefan Krauss https://lnkd.in/e43gx_jn MDPI University of Oslo #organonachip #microphysiologicalsystems #diseasemodels #drugtesting #openaccess #Abstract Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studying physiological processes, drug development, and testing in both academia and industry. This paper evaluates current platforms from the academic end-user perspective, elaborating on usability, complexity, and robustness. We surveyed 187 peers in 35 countries and grouped the responses according to preliminary knowledge and the source of the OoC systems that are used. The survey clearly shows that current commercial OoC platforms provide a substantial level of robustness and usability—which is also indicated by an increasing adaptation of the pharmaceutical industry—but a lack of complexity can challenge their use as a predictive platform. Self-made systems, on the other hand, are less robust and standardized but provide the opportunity to develop customized and more complex models, which are often needed for human disease modeling. This perspective serves as a guide for researchers in the OoC field and encourages the development of next-generation OoCs.

✨ Excited to Share Our Latest Research Publication! ✨ I'm thrilled to announce that our research article, titled "Rebamipide Nanocrystal with Improved Physicomechanical Properties and its Assessment through Bio-mimicking 3D Intestinal Permeability Model," has been successfully published in Nanoscale, a journal with an impressive Impact Factor of 5.8! 🎉 This work is the result of months of hard work, perseverance, and collaboration, exploring innovative solutions to enhance drug delivery and absorption. By developing a Rebamipide Nanocrystal, we have significantly improved its physicomechanical properties, aiming to optimize oral drug delivery for better therapeutic outcomes. Moreover, using a bio-mimicking 3D intestinal permeability model, we were able to assess the nanocrystal's enhanced permeability, simulating real physiological conditions.💊🧬 This accomplishment would not have been possible without the unwavering guidance and support of my mentors, Dr. Santanu Kaity and Dr. Shubhadeep Roy. Your insights, encouragement, and belief in this project have been instrumental in its success.✨ A heartfelt thanks to the entire team for their dedication, and to Nanoscale for the opportunity to contribute to this esteemed journal 👏 This journal is Accessible at: https://lnkd.in/gexHX5xg #Research #Nanotechnology #PharmaceuticalScience #DrugDelivery #Nanoscale #Publication #Innovation #Gratitude

🚨 𝐈𝐦𝐩𝐨𝐫𝐭𝐚𝐧𝐭 𝐔𝐩𝐝𝐚𝐭𝐞 𝐟𝐨𝐫 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬! 🚨 The following journals have been discontinued from Scopus as of May 2024: [1].             Alternative Therapies in Health and Medicine [2].             Azerbaijan Pharmaceutical and Pharmacotherapy Journal [3].             Bionatura [4].             Cancer Research, Statistics, and Treatment [5].             International Journal of Educational Methodology [6].             Journal of Biotech Research [7].             Journal of Eastern European and Central Asian Research [8].             Journal of Logistics, Informatics and Service Science [9].             Journal of Medical Pharmaceutical and Allied Sciences [10].        Military Medical Science Letters (Vojenske Zdravotnicke Listy) [11].        Nurture [12].        Revista Electronica de Veterinaria Researchers should take note of these changes and consider the impact on their publication plans and citation metrics. Stay informed and plan accordingly! #academic #phd #publication #scopus #research

A new paper to kick off 2024! 🎉 Check our last paper about the recent advances involving the use of tetracyclines loaded onto micro- or nanoparticles, intended for biomedical applications, published in the International Journal of Pharmaceutics. 🔬 💊 This review details the new therapeutic applications of tetracyclines, as well as their potential use for personalized regenerative medicine and current limitations. 🔍 🔍 You can access the full article here: https://lnkd.in/dX39XEd8 #newpaper #openaccess #article #tetracyclines #biomedicalapplications