Paragon Therapeutics, Inc.’s Post

This is a news & analysis overview on the recent clinical success by protagonists Moderna and BioNTech SE alongside others, such as Gritstone bio in transforming #mRNA #technology into #personalized #cancer #vaccines. Use of the technology for COVID was an "intermezzo", because the world needed it, in times of a pandemic. Synergistically, the learnings spurred the development further and paved the way for more acceptance and parallel developments in production and regulatory. It is great to see solid and promising Phase II data by Moderna and Merck #mRNA4157 in #melanoma with #pembrolizumab. Keep it going - tailored, patient-specific induction of immune system recognition of #neoantigens or #neoepitopes through #neoepitope #vaccination, even including combination with #checkpointinhibitors WILL transform #cancer #treatment and #prevention !!! "Personalized cancer vaccines pass first major clinical test" Nat Rev Drug Disc 08/2023 https://lnkd.in/dX3hkYaP

Our latest publication examines the critical role of CD8+ T cells in both cancer and viral infections. These immune cells are key players in the body's defense mechanism, identifying and eliminating cancerous and infected cells. However, their efficacy can be hindered in the tumor microenvironment or by chronic viral infections. Our research delves into the mechanisms of this suppression and explores potential strategies to reinvigorate these cells for therapeutic purposes. To read scholarly articles about this subject, visit us at www.opalbiopharma.com. Opal Bio Pharma (OBP) #OBP #Oman #Muscat #FDA #Opalbiopharma #Khazaen #CDC #Immunotherapy #vaccine #medicine #genetherapy #worldhealthorganization #VaccineEfficacy #GenotypeSpecificEfficacy #publichealth #VaccinationResearch #HealthcareInnovation #Immunology #CancerResearch #ViralInfections

Cell Proteomic Footprinting (CPF) is a technology that creates a specific cell "footprint" for authenticating cell populations, essential for developing cell-based pharmaceuticals like cancer vaccines. 🔗 https://lnkd.in/giYJZtiW #proteomic #footprint #cancer #vaccine #antigens #vaccination #cell #authentication

August is #NationalImmunizationAwarenessMonth ! 💉 Curious about the mechanisms of how the immune system fights cancer? ❔ Listen to our #podcast episode on types of #vaccines and how they work with Kenneth Kovan and David Berd. https://lnkd.in/eEucWPFZ #immunization #immunizations #immunizationawareness

Advancing The Development Of Targeted mRNA And Nanomedicine Therapeutics - Dr. #DrewWeissman, MD, PhD - 2023 #NobelPrize Laureate in Medicine; Director, #Penn Institute for RNA #Innovation #ProgressPotentialAndPossibilities #Penn #NobelPrize #DrewWeissman #mRNA #Vaccines #Immunology #CarTCells #CancerTherapeutics #Nanomedicine #LipidNanoparticles #GeneEditing #GeneTherapy #CellTherapy #StemCells

Stop worrying about time-consuming methods needed for panel optimization, validation and analysis. With SignalStar technology you can multiplex upto 8 targets simultaneously with flexible, highly validated antibody panels- accelerating data generation and letting you focus on results. . To know more contact us on [email protected] . #zellebiotechnology #biotechnology #antibodies #CARTtherapy #Immunotherapy #Immunology #CancerResearch #cellsignaling #cellbiology #proteomics #antibodies #proteins

Working with speed and agility allows Spyre Therapeutics to concurrently develop our lead assets, rational combinations, and diagnostic tools to treat IBD. We recognize the full breadth of this patient population and are continually working to establish a new standard of care in the field by approaching development with a different perspective and improve patient experience and outcomes.   To learn more about our scientific approach, visit www.spyre.com   #inflammation #immunology #biotech #crohnsdisease #ulcerativecolitis

Exciting News in Healthcare! A breakthrough in immunology: A new vaccine is changing the game for autoimmunity and transplant patients! 🌐 Read the full article to discover how this innovation promotes immune regulation, offering hope for a brighter, healthier future. 🩺💉 🔗 Dive into the details: https://bit.ly/46juW3l Credit: Journal of Clinical Investigation The Journal of Clinical Investigation #immune #vaccine #CD8 #healthscience #MedicalInnovation #Immunotherapy #HealthcareAdvancements #VaccineBreakthrough #meded #eMednews

Did you know that Linical is an award-winning vaccine and immunology CRO? As a result of developing vast and deep operational expertise in conducting immunology and vaccine trials, Linical's experience and success has been recognized and honored as Best Vaccine CRO across multiple years at the World Vaccine Congress. We understand the unique challenges associated with these trials, having vast experience in managing full-service, Phase I-IV immunology studies across the globe and extensive operational experience in many indications including: prophylactic vaccines, therapeutic vaccines, outbreaks & epidemics, respiratory & pulmonary disorders, allergic disorders, and autoimmune disorders. Learn more about why Linical is your trusted provider for success, speed, efficiency, flexibility, and quality in immunology and vaccine drug development 👉 https://hubs.la/Q028vdTb0 #clinicalresearch #immunology #vaccines #LinicalCRO

Did you know that a vaccine for Lyme disease was once available? Approved by the FDA in 1997, VLA15 was an effective protein vaccine discontinued only four years later due to many factors, including negative public perception. Learn how a team of scientists at the University of Pennsylvania led by Dr. Norbert Pardi are evaluating the potential of a new Lyme disease mRNA vaccine candidate. Read more on Our Blog! https://lnkd.in/eH6ZDMkC #lymedisease #lymediseasevaccine #vaccine #vaccinedevelopment #microbiology #immunology #mRNAvaccine