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https://lnkd.in/g_X7u4iC Article title: The differential usage of molecular machinery in brain cancer patients with iron-enriched glioma environments   Author(s): Brandon Lucke-Wold*; Michael Joseph Diaz; Joanna Song; Sai Batchu; Kevin Root; Karan Patel; Kamil Taneja   Journal: Journal of Surgery and Surgical Research   Journal ISSN: 2455-2968 Introduction: Gliomas are neuroepithelial tumors in the brain or spinal cord that arise from glial or precursor cells and include astrocytomas, oligodendrogliomas, and ependymomas. They are the most common malignant primary central nervous system tumors, representing 75% of cases in adults and 24% of all cases of primary brain and CNS tumors [1,2]. Despite radiotherapy and temozolomide chemotherapy, which are the current gold-standard first-line treatments, patients with gliomas, particularly the highly aggressive and most common subtype glioblastoma multiforme, still have a poor prognosis with a median survival time of 15 months and 5-year survival rates of 5% [3-6]. #GeneralSurgery #Anesthesia #EndocrineSurgery #OncologicSurgery #TraumaSurgery #GastrointestinalSurgery #VascularSurgery #EndovascularSurgery #TransplantationSurgery #PediatricSurgery #Neurosurgery #CosmeticSurgery #MaxillofacialSurgery #OralSurgery #DentalSurgery #OphthalmicSurgery #UrologicSurgery #ColonSurgery #RectalSurgery #HandSurgery #FootAndAnkleSurgery #OrthopedicSurgery #LaserSurgery #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #ReconstructiveSurgery #PlasticSurgery #CardiacSurgery #GynecologicalSurgery #Microsurgery #ThoracicSurgery #ComputerAssistedSurgery #CAS #RoboticSurgery #InvasiveSurgery #NonInvasiveSurgery #SurgicalProcedures #SurgicalInstruments #HeadAndNeckSurgery #BreastSurgery #ColorectalSurgery #DermatologicSurgery #HepatobiliarySurgery #PancreaticSurgery #SurgicalOncology #BoneSurgery #BurnSurgery #CerebralSurgery #CardiovascularSurgery #ExperimentalSurgery #BariatricSurgery #EpilepsySurgery #AbdominalSurgery

Happy to share our first publication of 2024! It is now well-established that complete surgical resection of MEG dipole clusters, reconstructed from interictal epileptiform discharges, is associated with favorable seizure outcomes. However, the impact of MEG cluster resection on the surgical resection volume is not known, nor is it clear whether this association is direct and causal, or it is mediated by other predictive factors. This information is essential for assessing the true clinical value and utility of MEG in epilepsy surgery, but was missing from the extant literature. In this paper, we have clarified these open questions and assessed the diagnostic accuracy of the MEG approach in our center. We found that complete resection of interictal MEG dipole clusters leads to good seizure outcomes in temporal as well as extratemporal lobe epilepsy without affecting the volume of surgical resection and independent of other prognostic factors, such as MRI finding, localized ictal EEG, EEG-MRI concordance and pathology. Our standard MEG approach can localize the epileptogenic zone with high accuracy (86%) and diagnostic odds ratio (42.5). These results provide crucial information, which was missing to date, supporting strong clinical value and utility of MEG in epilepsy surgery. We emphasize that MEG mapping should be used whenever feasible to improve postsurgical seizure outcomes and extend surgical treatment to patients who may not have been considered as candidates before. #epilepsy #meg #neurosurgery #neurophysiology

#Epilepsysurgery for #neuroglialtumors #shows #good #longterm #outcomes #Neuroscience #Surgery ------ https://lnkd.in/gDneaV3R ------ #Patients with #neuroglialtumors are #ideal #epilepsy #surgicalcandidates, with good long-term outcomes observed, according to a study published in Frontiers in Neurology. Attila Rácz, M.D., Ph.D., from the University Hospital Bonn in Germany, and colleagues evaluated long-term outcomes and potential influencing factors among 107 patients who underwent surgery for neuroglial tumors (2001 to 2020) at a single institution. The researchers found that 75% of the patients who underwent surgery achieved complete freedom from seizures at 12 months and 56% achieved complete freedom from seizures at the last follow-up visit (70.4 months; median: 40 months). For both 12-month follow-up outcomes and the longest available outcomes, completeness of resection was a crucial factor, while there was no consistent impact on postsurgical outcomes for lobar tumor localization, histology (ganglioglioma versus dysembryoplastic neuroepithelial tumor), history of bilateral tonic-clonic seizures prior to surgery, invasive diagnostics, side of surgery (dominant versus nondominant hemisphere), age at epilepsy onset, age at surgery, or epilepsy duration. Patients who underwent lesionectomy and lesionectomy with hippocampal resection showed similar outcomes. "#Neuroglialtumors present as excellent surgical substrates in treating structural epilepsy," the authors write. "To achieve an optimal postsurgical outcome, a complete lesion resection should be pursued whenever possible."

🔍 Exploring the Management of Non-Functioning Pituitary Adenomas (NFPAs) 📢 1.0 #CME Opportunity! Dive into the comprehensive review by Daniela Esposito, Daniel S Olsson, Oskar Ragnarsson, Michael Buchfelder, Thomas Skoglund, Gudmundur Johannsson on the optimal management of Non-functioning Pituitary Adenomas (NFPAs). This article covers crucial aspects of preoperative, perioperative, and postoperative management, shedding light on the current challenges and variations in treatment practices. 🧠 Key Insights: Treatment Options: Active surveillance, surgical resection, and radiotherapy. Surgical Indications: Primarily recommended for patients with visual impairment due to adenomas compressing optic structures. Radiotherapy Use: Reserved for large tumor remnants or recurrences post-surgery. Management Gaps: Lack of consensus on the timing and frequency of various assessments. 📈 Conclusion: The study underscores the need for prospective trials to establish standardized management strategies for NFPAs. It proposes an optimal management strategy based on available data, aiming to improve patient outcomes and well-being. 🔗 https://lnkd.in/dGciZrMK #PhysicianInsights #MedicalPractice #DoctorsUpdate #CME #PituitarySurgery #Endocrinology #Neurosurgery #MedicalResearch

https://lnkd.in/enuT28xA Article title: A study on statistical analysis for simulation of induced- immunity by exposition of CD8+, NK cells and memory cell and it relationship to cancer growth, happiness and delayed development syndrome, down syndrome   Author(s): Mohamed Alsadiq Ahmed Mansour*   Journal: Global Journal of Medical and Clinical Case Reports   Journal ISSN: 2455-5282 Abstract: This study is to analyze the statistics and causality inferences of simulation of tumor due to exposition on immune system, CD8+ and NK cells and their relationship to happiness and Down syndrome. Most of the observation has been carried out from reviewed data and information from literature and also one case of a kid 10 years old suffering from down syndrome that had been followed..... #Simulation #CD8+ #NKCells #Exposition #Cancer #Happiness #DownSyndrome #Dystochia #ForensicMedicine #ExperimentalMedicine #PediatricEmergencyMedicine #IntegrativeMedicine #AlternativeMedicine #EmergencyMedicine #GenomicMedicine #TranslationalMedicine #PulmonaryAndRespiratoryMedicine #TropicalMedicine #AddictionTherapy #Anatomy #AncientDiseasesAndPreventiveRemedies #BloodDisorders #HealthEducation #BoneMarrowTransplantation #Cloning #Hypertension #Leukemia #MycobacterialDiseases #OralHealth #TreatmentOfTrauma #AllergyAndClinicalImmunology #CancerResearchAndClinicalOncology #TranslationalOncology #ClinicalAndExperimentalNephrology #ClinicalChildPsychology #PsychotherapyAndPsychiatry #ClinicalChiropractic #ClinicalDensitometry #ClinicalEndocrinologyAndMetabolism #ClinicalEpidemiology #ClinicalGastroenterologyAndHepatology #ClinicalAndExperimentalOphthalmology #Pathology #ClinicalAndExperimentalOptometry #ClinicalAndExperimentalOtorhinolaryngology #Otolaryngology #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #ClinicalAndExperimentalPharmacologyAndPhysiology #ClinicalAnesthesiology #Anesthesia #ClinicalHypertension #AppliedThrombosis #ClinicalAndExperimentalAllergy #Dermatology #OralInvestigations #ClinicalOrthopaedics #ClinicalPathology #MolecularPathology #ClinicalMetastasis #Apheresis #ClinicalBiochemistryAndNutrition #Biomechanics #ClinicalCardiology #ClinicalGeneticsAndHematology #ClinicalInterventionsInAging #ClinicalLaboratoryAnalysis #ClinicalLinguistics #Phonetics #ClinicalLipidology #ClinicalMicrobiology #Antimicrobials #InfectiousDiseases #ClinicalMonitoringAndComputing #ClinicalNeurology #Neurosurgery #Neurophysiology #Neuropsychology #Neuroradiology #Neuroscience #ClinicalPharmacology #Toxicology #PharmacyAndTherapeutics #ClinicalPhysiology #ClinicalImaging #FunctionalImaging #ClinicalRadiology #ClinicalRehabilitation #ClinicalRespiratory #ClinicalRheumatology #ClinicalTherapeutics #ClinicalTrials #ClinicalTransplantation #ClinicalUltrasound #ClinicalVirology #TherapeuticsAndClinicalRiskManagement #VeterinaryClinicalPathology

#Study #highlights #disparities in #lifesaving #treatment for #stroke #after #heartsurgery #Neuroscience #Cardiology ------ https://lnkd.in/g69EXxh2 ------ Although #stroketreatments have vastly improved in recent years,leading to better outcomes for many,one population of patients often does not receive these effective therapies: those who #suffer #strokes following #heartsurgery. In fact,these #patients are less than half as likely as #strokepatients who haven't undergone #heartsurgery to receive what could be lifesaving and disability-preventing treatments, according to a Yale School of Medicine study recently published in JAMA Neurology #Endovascularthrombectomy, which involves #snaking a #thin #catheter #up an #artery from the #wrist or #groin to #clear #arterialblockages in the #brain,is by far the #most #effective #treatment for #ischemicstrokes,which are the #most #common #form of #stroke—#caused by a #blockage of #bloodflow to the #brain. However,the #treatment must be #administered in the #first #24hours of #symptoms, #ideally #sooner For a variety of reasons, detecting strokes in heart surgery patients this quickly can be tricky. Also,surgery patients are generally not eligible to receive the other major treatment modality for ischemic stroke,intravenous thrombolysis with tissue plasminogen activator (tPA),due to its blood-thinning effects To understand whether heart surgery patients are less likely to receive post-operative endovascular treatment if they suffer strokes,Adam de Havenon,MD,a vascular neurologist and associate professor of neurology at Yale School of Medicine,and his colleagues sifted through a nationwide database of stroke patient data from nearly 5,000 hospitals between 2016 and 2020 The team found that,following heart procedures,patients who suffered ischemic strokes within three days after their procedure were less than half as likely to receive endovascular stroke treatment as patients whose ischemic strokes did not follow cardiac treatments #Cardiacsurgery,such as valve repair or implanting a stent,carries a high risk of triggering a stroke by potentially causing a clot that goes to the brain or damaging the arteries that carry blood directly from the heart to the brain. The procedure is second only to brain surgery in terms of stroke risk following surgery. Cardiac implants,like pacemakers or stents,can also raise the risk of stroke following surgery "The data show that even up to 2020,we were not offering the single most effective treatment for ischemic stroke that we have to individuals after cardiac surgery," said de Havenon, who led the study. "There's a major disparity here." The researchers used the National Inpatient Sample database, a large database that captures data from inpatients at thousands of U.S. hospitals. The team analyzed data from more than 630,000 stroke patients, including more than 12,000 who'd had cardiac procedures.

https://lnkd.in/gHyAK_yS Article title: Middle Ear Carcinoid Tumor: A rare case Author(s): Eng Siang Lee; Ing Ping Tang Journal: Archives of Otolaryngology and Rhinology Journal ISSN: 2455-1759 Abstract: Introduction: Carcinoid tumor of the middle ear (ME) is exceedingly rare and thus its diagnosis is frequently delayed. It is also hard to differentiate between middle ear carcinoid from the middle ear adenoma. Definitive diagnosis is made by identifying neurosecretory tumor cells using immunohistochemistry and electron microscopy. #CarcinoidTumor #MiddleEar #TemporalBone #Otalgia #HearingLoss #FacialPalsy #Diagnosis #HeadAndNeckSurgery #OralCancer #Otology #Laryngology #SinusSurgery #Sinusitis #Neurotology #Rhinology #FacialPlasticAndReconstructiveSurgery #VoiceDisorders #PediatricOtolaryngology #HearingLoss #EarNoseThroat #OtitisMedia #Tonsillitis #VocalCordParalysis #ThoracicCancer #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #NasopharyngealCarcinoma #LaryngealTrauma #NasalPolyps #ObstructiveSleepApnoea #Rhinoplasty #Tracheostomy #ParathyroidSurgery #Audiology #ThyroidCancer #Mastoiditis #Tonsillectomy #SwallowingDisorders #ENTDiseases #NasalPolyposis #NasalSurgery #NasalMucosa #NasalCancer #MRIHeadAndNeck #NeckTrauma #NeckMuscles #HearingVoices #NasalEndoscopy #MicroscopyOfTheEar #HearingImpairmentAndDeafness #HearingDisorders #CleftLip #ThroatCancer

🧠𝗤'𝗔𝗽𝗲𝗹 𝗠𝗲𝗱𝗶𝗰𝗮𝗹 𝗜𝗻𝗰. 𝗟𝗮𝘂𝗻𝗰𝗵𝗲𝘀 "𝗛𝗶𝗽𝗽𝗼" 𝗧𝗵𝗲 𝗡𝗲𝘄 𝗚𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝗼𝗻 𝗔𝘀𝗽𝗶𝗿𝗮𝘁𝗶𝗼𝗻 𝗦𝘆𝘀𝘁𝗲𝗺 𝗳𝗼𝗿 𝗦𝘁𝗿𝗼𝗸𝗲 𝗧𝗵𝗿𝗼𝗺𝗯𝗲𝗰𝘁𝗼𝗺𝘆 Q'Apel Medical Inc. launched a new generation of it's aspiration technology - the 072 Hippo Aspiration System, developed for patients suffering from a stroke due to a large vessel occlusion. 🤔𝙒𝙝𝙖𝙩 𝙞𝙨 𝙡𝙖𝙧𝙜𝙚 𝙫𝙚𝙨𝙨𝙚𝙡 𝙤𝙘𝙘𝙡𝙪𝙨𝙞𝙤𝙣 (𝙇𝙑𝙊)? Large vessel occlusion (LVO) is the obstruction of large, proximal cerebral arteries and accounts for 24–46% of acute ischaemic stroke (AIS) Due to the involvement of proximal vasculature, significant brain regions are often affected, resulting in large neurological deficits 𝙒𝙝𝙖𝙩 𝙙𝙤𝙚𝙨 𝙩𝙝𝙚𝙞𝙧 𝙣𝙚𝙬 𝙜𝙚𝙣𝙚𝙧𝙖𝙩𝙞𝙤𝙣 𝙙𝙤? The adaptive tip of the Hippo catheter redefines precision in clot engagement and removal, ensuring tailored performance for varying clot morphologies and sizes. This unique feature offers physicians: 🩸 Real-time visibility and control during the critical phases of the procedure, providing insights previously unavailable. 🩸Improved visibility is crucial for the physician in confirming engagement with the blockage, improving the odds for high first-pass success, and fewer passes, leading to better functional outcomes for stroke victims. 🪄𝙏𝙝𝙚𝙞𝙧 𝙁𝙪𝙡𝙡 𝙎𝙤𝙡𝙪𝙩𝙞𝙤𝙣 The adaptive tip of the Hippo catheter is complemented by the Cheetah, a flexible guiding companion designed to accelerate delivery of Hippo to the face of the clot. Together, Hippo and Cheetah create a synergistic system ensuring unparalleled speed, precision, and integration in thrombectomy procedures and is the ideal complement to Q'Apel's market-leading Walrus Balloon Guide Catheter. 🌟𝗖𝗼𝗻𝗴𝗿𝗮𝘁𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀 𝗤'𝗔𝗽𝗲𝗹🌟 #thrombectomy #neurothrombectomy #neurology #brain #brainhealth #stroke #aspiration #newlaunch #productlaunch #fdaapproval #fda #neuroscience #interventionalradiology

https://lnkd.in/gx5qPV6k Article title: Epidemiological factors in patients with larynx cancer treated by surgery, radiotherapy or therapeutic associations Author(s): Gustavo Henrique Barbosa Nunes Da Silva; Michelle Gomes Miranda; Débora Souza Rodrigues; Geralda Rodrigues De Souza; Christiana Vargas Ribeiro Journal: Archives of Otolaryngology and Rhinology Journal ISSN: 2455-1759 Abstract: The aim of this research was to analyze the influence of epidemiological factors in patients with laryngeal carcinoma treated by surgery, radiotherapy or therapeutic associations. A quantitative retrospective analysis was performed, based on a master's thesis, of 34 individuals with this pathology, taking into consideration: gender, age, life habits and type of treatment. These factors were associated with the projections of the number of new cases, starting in 2018, according to INCA and IARC data. Due to lifestyle, men are more likely to get laryngeal cancer, and the association of alcohol and tobacco increases the chance and degree of manifestation of this carcinoma. #CysticLymphNode #Metastasis #PapillaryCarcinoma #Thyroid #HeadAndNeckSurgery #OralCancer #Otology #Laryngology #SinusSurgery #Sinusitis #Neurotology #Rhinology #FacialPlasticAndReconstructiveSurgery #VoiceDisorders #PediatricOtolaryngology #HearingLoss #EarNoseThroat #OtitisMedia #Tonsillitis #VocalCordParalysis #ThoracicCancer #Peertechz #PeertechzPublications #OpenAccess #ScientificJournals #PeerReviewedJournals #OpenAccessPublishers #NasopharyngealCarcinoma #LaryngealTrauma #NasalPolyps #ObstructiveSleepApnoea #Rhinoplasty #Tracheostomy #ParathyroidSurgery #Audiology #ThyroidCancer #Mastoiditis #Tonsillectomy #SwallowingDisorders #ENTDiseases #NasalPolyposis #NasalSurgery #NasalMucosa #NasalCancer #MRIHeadAndNeck #NeckTrauma #NeckMuscles #HearingVoices #NasalEndoscopy #MicroscopyOfTheEar #HearingImpairmentAndDeafness #HearingDisorders #CleftLip #ThroatCancer